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- Matuozzo, D, et al.
(författare)
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Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19
- 2022
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Ingår i: medRxiv : the preprint server for health sciences. - : Cold Spring Harbor Laboratory.
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- BackgroundWe previously reported inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity in 1-5% of unvaccinated patients with life-threatening COVID-19, and auto-antibodies against type I IFN in another 15-20% of cases.MethodsWe report here a genome-wide rare variant burden association analysis in 3,269 unvaccinated patients with life-threatening COVID-19 (1,301 previously reported and 1,968 new patients), and 1,373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. A quarter of the patients tested had antibodies against type I IFN (234 of 928) and were excluded from the analysis.ResultsNo gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants wasTLR7, with an OR of 27.68 (95%CI:1.5-528.7,P=1.1×10−4), in analyses restricted to biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR=3.70 [95%CI:1.3-8.2],P=2.1×10−4). Adding the recently reportedTYK2COVID-19 locus strengthened this enrichment, particularly under a recessive model (OR=19.65 [95%CI:2.1-2635.4];P=3.4×10−3). When these 14 loci andTLR7were considered, all individuals hemizygous (n=20) or homozygous (n=5) for pLOF or bLOF variants were patients (OR=39.19 [95%CI:5.2-5037.0],P=4.7×10−7), who also showed an enrichment in heterozygous variants (OR=2.36 [95%CI:1.0-5.9],P=0.02). Finally, the patients with pLOF or bLOF variants at these 15 loci were significantly younger (mean age [SD]=43.3 [20.3] years) than the other patients (56.0 [17.3] years;P=1.68×10−5).ConclusionsRare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old.
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- Bornstein, Marc H., et al.
(författare)
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’Mixed Blessings’ : Parental religiousness, parenting, and child adjustment in global perspective
- 2022
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Ingår i: Parenting. - New York : Taylor & Francis. - 9781000556285 - 9780367765682 - 9781003167570 ; , s. 392-415
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Background: Most studies of the effects of parental religiousness on parenting and child development focus on a particular religion or cultural group, which limits generalizations that can be made about the effects of parental religiousness on family life.Methods: We assessed the associations among parental religiousness, parenting, and children’s adjustment in a 3-year longitudinal investigation of 1,198 families from nine countries. We included four religions (Catholicism, Protestantism, Buddhism, and Islam) plus unaffiliated parents, two positive (efficacy and warmth) and two negative (control and rejection) parenting practices, and two positive (social competence and school performance) and two negative (internalizing and externalizing) child outcomes. Parents and children were informants.Results: Greater parent religiousness had both positive and negative associations with parenting and child adjustment. Greater parent religiousness when children were age 8 was associated with higher parental efficacy at age 9 and, in turn, children’s better social competence and school performance and fewer child internalizing and externalizing problems at age 10. However, greater parent religiousness at age 8 was also associated with more parental control at age 9, which in turn was associated with more child internalizing and externalizing problems at age 10. Parental warmth and rejection had inconsistent relations with parental religiousness and child outcomes depending on the informant. With a few exceptions, similar patterns of results held for all four religions and the unaffiliated, nine sites, mothers and fathers, girls and boys, and controlling for demographic covariates.Conclusions: Parents and children agree that parental religiousness is associated with more controlling parenting and, in turn, increased child problem behaviors. However, children see religiousness as related to parental rejection, whereas parents see religiousness as related to parental efficacy and warmth, which have different associations with child functioning. Studying both parent and child views of religiousness and parenting is important to understand the effects of parental religiousness on parents and children.
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- Campbell, Cory, et al.
(författare)
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Parallel Growth of Children’s Internalizing Behaviors Predicted by Positive Parenting Behaviors
- 2021
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Ingår i: SRCD 2021 Virtual Biennial Meeting.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The global outbreak of COVID-19 has impacted all systems essential to human life and wellbeing (Masten & Motto-Stefanidi, 2020). The complex combination of health and economic stressors together with difficulty accessing protective factors may impact the family system in particular. Families differ in their responses to stressors (Bonanno et al., 2010), and the way in which families adjust to events and transitions related to the pandemic may be related to the distress perceived by children and their long-term wellbeing (Felix et al., 2013).This symposium will examine whether and through which processes families adjust during the global outbreak of COVID-19. We explore 2 research questions: 1)What did families do during the pandemic to maintain resilience? 2)What are the main protective and risk factors within the family context that are related to children’s and adolescents’ adjustment during this stressful and potentially traumatic event?Three strengths characterize the symposium. First, longitudinal designs with pre- and post-onset measurements enabled us to capture the dynamic nature of changes impacted by the COVID-19 outbreak. Second, the global nature of the outbreak is represented in cross-cultural perspective to understand commonalities and specificities of the processes activated by the event in different countries from Europe, North America, and Asia. Finally, mechanisms of resiliency and vulnerability examining the adjustment of the family members are assessed through longitudinal moderation and mediation analyses.
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- Hoffman, Johan, 1974-, et al.
(författare)
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The FEniCS project
- 2003
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The goal of the FEniCS project is to develop open-source software for the automation of Computational Mathematical Modeling (CMM). FEniCS is a joint project between the Toyota Technological Institute at Chicago, the University of Chicago, and Chalmers University of Technology. The vision of FEniCS is to set a new standard in CMM, which can be described as the Automation of CMM, towards the goals of generality, efficiency, and simplicity, concerning mathematical methodology, implementation, and application.
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