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1.	Kilpeläinen, Tuomas O, et al. (author) Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. 2011 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 43:8, s. 753-60 Journal article (peer-reviewed)abstract Genome-wide association studies have identified 32 loci influencing body mass index, but this measure does not distinguish lean from fat mass. To identify adiposity loci, we meta-analyzed associations between ∼2.5 million SNPs and body fat percentage from 36,626 individuals and followed up the 14 most significant (P < 10(-6)) independent loci in 39,576 individuals. We confirmed a previously established adiposity locus in FTO (P = 3 × 10(-26)) and identified two new loci associated with body fat percentage, one near IRS1 (P = 4 × 10(-11)) and one near SPRY2 (P = 3 × 10(-8)). Both loci contain genes with potential links to adipocyte physiology. Notably, the body-fat-decreasing allele near IRS1 is associated with decreased IRS1 expression and with an impaired metabolic profile, including an increased visceral to subcutaneous fat ratio, insulin resistance, dyslipidemia, risk of diabetes and coronary artery disease and decreased adiponectin levels. Our findings provide new insights into adiposity and insulin resistance.
2.	Zillikens, M Carola, et al. (author) Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. 2017 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8:1 Journal article (peer-reviewed)abstract A correction to this article has been published and is linked from the HTML version of this article.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Khaw, Kay-Tee (2); Vandenput, Liesbeth, ... (2); Lorentzon, Mattias, ... (2); Salomaa, Veikko (2); Jula, Antti (2); Perola, Markus (2); show more...; Soranzo, Nicole (2); Campbell, Harry (2); Rudan, Igor (2); Ohlsson, Claes, 1965 (2); Wareham, Nicholas J. (2); Stancáková, Alena (2); Kuusisto, Johanna (2); Laakso, Markku (2); Kilpeläinen, Tuomas ... (2); Amin, Najaf (2); van Duijn, Cornelia ... (2); Ingelsson, Erik (2); Ripatti, Samuli (2); Thorleifsson, Gudmar (2); Thorsteinsdottir, Un ... (2); Stefansson, Kari (2); Mellström, Dan, 1945 (2); Oostra, Ben A. (2); Gieger, Christian (2); Wichmann, H. Erich (2); Barroso, Ines (2); Walker, Mark (2); Spector, Timothy D (2); Luan, Jian'an (2); Wilson, James F. (2); Ljunggren, Östen (2); Jansson, John-Olov, ... (2); Zillikens, M. Carola (2); Rivadeneira, Fernand ... (2); Eiriksdottir, Gudny (2); Garcia, Melissa (2); Harris, Tamara B (2); Klopp, Norman (2); Liu, Yongmei (2); Loos, Ruth J F (2); Hofman, Albert (2); Uitterlinden, André ... (2); Psaty, Bruce M (2); Hayward, Caroline (2); Gudnason, Vilmundur (2); Mitchell, Braxton D. (2); Döring, Angela (2); Kiel, Douglas P. (2); Karasik, David (2); show less...

University: University of Gothenburg (2)Undo refine; Uppsala University (1)Undo refine; Lund University (1); Karolinska Institutet (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

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