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Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease

Roe, James M. (författare)
Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
Vidal-Piñeiro, Didac (författare)
Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
Sørensen, Øystein (författare)
Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
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Brandmaier, Andreas M. (författare)
Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
Düzel, Sandra (författare)
Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
Gonzalez, Hector A. (författare)
Center for Vital Longevity, University of Texas, TX, Dallas, United States
Kievit, Rogier A. (författare)
MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom
Knights, Ethan (författare)
MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom
Kühn, Simone (författare)
Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Lindenberger, Ulman (författare)
Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Mowinckel, Athanasia M. (författare)
Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
Nyberg, Lars, 1966- (författare)
Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)
Park, Denise C. (författare)
Center for Vital Longevity, University of Texas, TX, Dallas, United States
Pudas, Sara, Fil. Dr. 1983- (författare)
Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)
Rundle, Melissa M. (författare)
Center for Vital Longevity, University of Texas, TX, Dallas, United States
Walhovd, Kristine B. (författare)
Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway
Fjell, Anders M. (författare)
Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway
Westerhausen, René (författare)
Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
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 (creator_code:org_t)
2021-02-01
2021
Engelska.
Ingår i: Nature Communications. - : Nature Research. - 2041-1723. ; 12:1
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://www.nature.c...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Aging and Alzheimer’s disease (AD) are associated with progressive brain disorganization. Although structural asymmetry is an organizing feature of the cerebral cortex it is unknown whether continuous age- and AD-related cortical degradation alters cortical asymmetry. Here, in multiple longitudinal adult lifespan cohorts we show that higher-order cortical regions exhibiting pronounced asymmetry at age ~20 also show progressive asymmetry-loss across the adult lifespan. Hence, accelerated thinning of the (previously) thicker homotopic hemisphere is a feature of aging. This organizational principle showed high consistency across cohorts in the Lifebrain consortium, and both the topological patterns and temporal dynamics of asymmetry-loss were markedly similar across replicating samples. Asymmetry-change was further accelerated in AD. Results suggest a system-wide dedifferentiation of the adaptive asymmetric organization of heteromodal cortex in aging and AD.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

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