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| 2. |
- Knutsson, Mikael, 1974
(författare)
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On Power Estimation and Score Predictions in Affected Sib-Pair Linkage Analysis
- 2002
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis consists of three papers in statistical genetics, with the emphasis on affected sib-pair linkage analysis. In Paper A, a method to derive the power of linkage analysis in genome scans, using a stepwise approach, is presented. A simulation method to generate marker data is described and power functions are obtained combining the marker simulations with calculations of appropriate linkage statistic moments and a multivariate normal approximation. The approach is tested and illustrated in an example regarding multiple sclerosis. Paper B treats the situation when the family reproduction processes are interfered by the births of affected offspring. The emphasis is on negative> interference, i.e. when the birth of an affected offspring reduces the probability of further reproduction, denoted limitation. The effects of limitation, in connection to the estimation of the sibling prevalence and the power of affected sib-pair analysis, are discussed. Some results are also given for the opposite case of positive interference, denoted compensation. In Paper C, a prediction score graph is derived to compensate for incomplete information in linkage analysis. Contrary to the conservative nonparametric linkage (NPL) score, where the calculations are conditional on the null hypothesis of no linkage, the prediction score is derived conditional on an alternative hypothesis, estimated from the existing data. Performing a joint analysis, using both the NPL- and the prediction graph, new potential gene harbouring regions may be identified. Furthermore, regions originally displaying large peaks, despite low information content, can be reanalysed so that the disease loci can be located with an increased accuracy. The value of the prediction score is illustrated in an example regarding the celiac disease. MSC 2000 subject classification: 62P10, 92D10
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| 3. |
- Sjöberg, Elisabeth, et al.
(författare)
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Social Media and Its Dual Use in Biopreparedness: Communication and Visualization Tools in an Animal Bioterrorism Incident
- 2013
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Ingår i: Biosecurity and Bioterrorism. - : Mary Ann Liebert Inc. - 1538-7135 .- 1557-850X. ; 11:Supplement 1, s. S264-S275
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Tidskriftsartikel (refereegranskat)abstract
- This article focuses on social media and interactive challenges for emergency organizations during a bioterrorism or agroterrorism incident, and it outlines the dual-use dilemma of social media. Attackers or terrorists can use social media as their modus of operandi, and defenders, including emergency organizations in law enforcement and public and animal health, can use it for peaceful purposes. To get a better understanding of the uses of social media in these situations, a workshop was arranged in Stockholm, Sweden, to raise awareness about social media and animal bioterrorism threats. Fifty-six experts and crisis communicators from international and national organizations participated. As a result of the workshop, it was concluded that emergency organizations can collect valuable information and monitor social media before, during, and after an outbreak. In order to make use of interactive communication to obtain collective intelligence from the public, emergency organizations must adapt to social networking technologies, requiring multidisciplinary knowledge in the fields of information, communication, IT, and biopreparedness. Social network messaging during a disease outbreak can be visualized in stream graphs and networks showing clusters of Twitter and Facebook users. The visualization of social media can be an important preparedness tool in the response to bioterrorism and agroterrorism.
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| 4. |
- Svensson, Henrik, 1982, et al.
(författare)
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Influence of Pt on the metal-oxide interface during high temperature oxidation of NiAl bulk materials
- 2009
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Ingår i: Corrosion Science. - : Elsevier BV. - 0010-938X. ; 51:3, s. 539-546
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of the investigation was to study the mechanisms improving oxide scale adherence in Pt-free and Pt-rich beta-NiAl materials during high temperature oxidation. Theoretical density-functional theory (DFT) calculations were used to calculate the work of separation of the beta-NiAl(111)/alpha-Al(2)O(3)(0001) metal-oxide interfaces, in pure NiAl and Pt-rich NiAl materials. The experimental work was focused on the studies of the metal-oxide interface, its development and morphology. Based on the theoretical and experimental results a complementary picture is presented for a better understanding of the Pt effect on the oxidation and oxide adhesion. It is shown that the interfacial bonding is decreased with addition of Pt to beta-NiAl. The beneficial effect of Pt on the adhesion energy is attributed to the enhancement of contact areas between the oxide and the metal. The influence of Pt on the diffusion of Al and the formation of interfacial voids is also discussed.
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