| 1. |
- DeYoung, Colin G., et al.
(författare)
-
Variation in the catechol-O-methyltransferase Val(158)Met polymorphism associated with conduct disorder and ADHD symptoms, among adolescent male delinquents
- 2010
-
Ingår i: Psychiatric Genetics. - 0955-8829 .- 1473-5873. ; 20:1, s. 20-24
-
Tidskriftsartikel (refereegranskat)abstract
- Objective Variation in the catechol-O-methyltransferase gene (COMT) has been associated with antisocial behavior in populations with attention deficit/hyperactivity disorder (ADHD). This study examined whether COMT would predict antisocial behavior in a sample with high levels of behavior problems, not necessarily ADHD. In addition, because previous research suggests that COMT may be associated with ADHD in males, association between COMT and ADHD symptoms was examined. Method This study tested whether variation in three polymorphisms of the COMT gene was predictive of symptoms of conduct disorder and ADHD, in a sample of 174 incarcerated Russian adolescent male delinquents. Results The Val allele of the Val(158)Met polymorphism was significantly associated with conduct disorder diagnosis and symptoms, whereas the Met allele was associated with ADHD symptoms. Conclusion The Val(158)Met polymorphism of the COMT gene shows a complex relation to behavior problems, influencing conduct disorder and ADHD symptoms in opposite directions in a high-risk population. Psychiatr Genet 20:20-24 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
|
|
| 2. |
- Donati, P., et al.
(författare)
-
The Gaia-ESO Survey : Reevaluation of the parameters of the open cluster Trumpler 20 using photometry and spectroscopy
- 2014
-
Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 561, s. A94-
-
Tidskriftsartikel (refereegranskat)abstract
- Trumpler 20 is an old open cluster (OC) located toward the Galactic centre, at about 3 kpc from the Sun and similar to 7 kpc from the Galactic centre. Its position makes this cluster particularly interesting in the framework of the chemical properties of the Galactic disc because very few old OCs reside in the inner part of the disc. For this reason it has been selected as a cluster target of the Gaia-ESO Survey, and spectra of many stars in the main-sequence and red-clump phases are now available. Moreover, although it has been studied by several authors in the past, no consensus on the evolutionary status of Tr 20 has been reached. The heavy contamination of field stars (the line of sight of Tr 20 crosses the Carina spiral arm) complicates a correct interpretation. Another interesting aspect of the cluster is that it shows a broadened main-sequence turn-off and a prominent and extended red-clump, characteristics that are not easily explained by classical evolutionary models. Exploiting both spectroscopic information from the Gaia-ESO Survey (and the ESO archive) and literature photometry, we obtain a detailed and accurate analysis of the properties of the cluster. We make use of the first accurate metallicity measurement ever obtained from several spectra of red clump stars, and of cluster membership determination using radial velocities. According to the evolutionary models adopted, we find that Tr 20 has an age in the range 1.35-1.66 Gyr, an average reddening E(B - V) in the range 0.31-0.35 mag, and a distance modulus (m - M)(0) between 12.64 and 12.72 mag. The spectroscopic metallicity is [Fe/H] = +0.17 dex. We discuss the structural properties of the object and constrain possible hypotheses for its broadened upper main sequence by estimating the effect of differential reddening and its extended red clump.
|
|
| 3. |
- Grigorenko, Elena L., et al.
(författare)
-
Aggressive behaviour, related conduct problems, and variation in genes affecting dopamine turnover
- 2010
-
Ingår i: Aggressive Behavior. - : Wiley. - 0096-140X .- 1098-2337. ; 36:3, s. 158-176
-
Tidskriftsartikel (refereegranskat)abstract
- A number of dopamine-related genes have been implicated in the etiology of violent behavior and conduct problems. Of these genes, the ones that code for the enzymes that influence the turnover of dopamine (DA) have received the most attention. In this study, we investigated 12 genetic polymorphisms in four genes involved with DA functioning (COMT, MAOA and MAOB, and DβH) in 179 incarcerated male Russian adolescents and two groups of matched controls: boys without criminal records referred to by their teachers as (a) “troubled-behavior-free” boys, n=182; and (b) “troubled-behavior” boys, n=60. The participants were classified as (1) being incarcerated or not, (2) having the DSM-IV diagnosis of conduct disorder (CD) or not, and (3) having committed violent or nonviolent crimes (for the incarcerated individuals only). The findings indicate that, although no single genetic variant in any of the four genes differentiated individuals in the investigated groups, various linear combinations (i.e., haplotypes) and nonlinear combinations (i.e., interactions between variants within and across genes) of genetic variants resulted in informative and robust classifications for two of the three groupings. These combinations of genetic variants differentiated individuals in incarceration vs. nonincarcerated and CD vs. no-CD groups; no informative combinations were established consistently for the grouping by crime within the incarcerated individuals. This study underscores the importance of considering multiple rather than single markers within candidate genes and their additive and interactive combinations, both with themselves and with nongenetic indicators, while attempting to understand the genetic background of such complex behaviors as serious conduct problems.
|
|
| 4. |
- Grigorenko, Elena L., et al.
(författare)
-
Exploring interactive effects on genes and environments in etiology of individual differences in reading comprehension
- 2007
-
Ingår i: Development and Psychopathology. - 0954-5794 .- 1469-2198. ; 19:4, s. 1089-1103
-
Tidskriftsartikel (refereegranskat)abstract
- It is established that reading and reading-related processes are heritable; genes thus play an important role in the foundation of individual differences in reading. In this article, we focus on one facet of reading–comprehension. Comprehension is a higher order cognitive skill that requires many other cognitive processes for it to unfold completely and successfully. One such process is executive functioning, which has been associated with genetic variation in the catechol-O-methyltransferase (COMT) gene. Genotypes and haplotypes of four single nucleotide polymorphisms in COMT were investigated in 179 incarcerated adolescent delinquents. Four hierarchical logistic regression models predicting the presence/absence of comprehension difficulties were fitted to the data; genetic variation in COMT and the presence/absence of maternal rejection were investigated as main effects and as effects acting interactively. Three out of four interaction terms were found to be important predictors of individual differences in comprehension. These findings were supported by the results of the haplotype analyses, in which the four investigated polymorphisms were considered simultaneously.
|
|
| 5. |
- Haeffel, Gerald J., et al.
(författare)
-
Association Between Polymorphisms in the Dopamine Transporter Gene and Depression : Evidence for a Gene-Environment Interaction in a Sample of Juvenile Detainees
- 2008
-
Ingår i: Psychological Science. - : SAGE Publications. - 0956-7976 .- 1467-9280. ; 19:1, s. 62-69
-
Tidskriftsartikel (refereegranskat)abstract
- Previous research has generated examples of how genetic and environmental factors can interact to create risk for psychopathology. Using a gene-by-environment (G × E) interaction design, we tested whether three polymorphisms in the dopamine transporter gene (DAT1, also referred to as SLC6A3, located at 5p15.33) interacted with maternal parenting style to predict first-onset episodes of depression. Participants were male adolescents (N= 176) recruited from a juvenile detention center in northern Russia. As hypothesized, one of the polymorphisms (rs40184) moderated the effect of perceived maternal rejection on the onset of major depressive disorder, as well as on suicidal ideation. Further, this G × E interaction was specific to depression; it did not predict clinically significant anxiety. These results highlight the need for further research investigating the moderating effects of dopaminergic genes on depression.
|
|
| 6. |
- Hodes, Matthew, et al.
(författare)
-
Refugees in Europe : national overviews from key countries with a special focus on child and adolescent mental health
- 2018
-
Ingår i: European Child and Adolescent Psychiatry. - : Springer Science and Business Media LLC. - 1018-8827 .- 1435-165X. ; 27:4, s. 389-399
-
Tidskriftsartikel (refereegranskat)abstract
- Many European countries are becoming multicultural at a previously unseen rate. The number of immigrants including refugees has considerably increased since 2008, and especially after the beginning of the war in Syria. In 2015, 88,300 unaccompanied minors sought asylum in the Member States of the European Union (EU) and most came from Syria, Afghanistan, Iran, Iraq, Somalia and Eritrea. As a reaction to increased immigration, governments in many countries including Germany, Sweden and Norway implemented more restrictive immigration policy. A requirement for all countries, however, is the protection and welfare provision for all arriving children, regardless of their nationality, ensured by international and national legal frameworks. This paper provides an overview of the post 2015 immigration crisis in key European countries with a special focus on current demographics, refugee children, mental health studies, policies and practical support available for refugees.
|
|
| 7. |
|
|
| 8. |
- Isaksson, Johan, et al.
(författare)
-
Community Violence Exposure and Eating Disorder Symptoms among Belgian, Russian and US Adolescents : Cross-Country and Gender Perspectives.
- 2023
-
Ingår i: Child Psychiatry and Human Development. - : Springer. - 0009-398X .- 1573-3327.
-
Tidskriftsartikel (refereegranskat)abstract
- Community violence exposure (CVE) is one of the most common adverse childhood experiences worldwide. Despite this, its potential effect on disordered eating in adolescents from different cultures is underexplored. In the present cross-sectional study, self-reported data were collected from 9751 students (Mean age = 14.27) from Belgium, Russia and the US on CVE (witnessing violence and violence victimization), eating disorder (ED) symptoms (ED thoughts with associated compensatory behaviors), and comorbid symptoms of posttraumatic stress, depression and anxiety. Increased CVE (from no exposure to witnessing to victimization) was associated with more ED symptoms, and the associations remained significant after adjusting for comorbid conditions. The associations were similar for adolescents across the three countries. No gender differences were observed in the association between CVE and ED symptoms, even though girls in general reported more ED symptoms than boys. We conclude that CVE appears to be associated with ED symptoms in three culturally different samples of adolescents.
|
|
| 9. |
- Isaksson, Johan, et al.
(författare)
-
Exploring possible association between D beta H genotype (C1021T), early onset of conduct disorder and psychopathic traits in juvenile delinquents
- 2016
-
Ingår i: European Archives of Psychiatry and Clinical Neuroscience. - : Springer Science and Business Media LLC. - 0940-1334 .- 1433-8491. ; 266:8, s. 771-773
-
Tidskriftsartikel (refereegranskat)abstract
- Early onset of conduct disorder (CD) with callous-unemotional traits has been linked to low levels of dopamine β-hydroxylase (DβH), an enzyme involved in dopamine turnover. The C1021T polymorphism in the DβH gene is a major quantitative-trait locus, regulating the level of DβH. In this study of juvenile delinquents from Northern Russia (n = 180), the polymorphism at -1021 was associated neither with early-onset CD nor with psychopathic traits. Association was found between psychopathic traits and early-onset CD, ADHD and mania.
|
|
| 10. |
- Isaksson, Johan, et al.
(författare)
-
Exploring possible association between DβH genotype (C1021T), early onset of conduct disorder and psychopathic traits in juvenile delinquents.
- 2016
-
Ingår i: European Archives of Psychiatry and Clinical Neuroscience. - : Springer Science and Business Media LLC. - 0940-1334 .- 1433-8491. ; 266:8, s. 771-773
-
Tidskriftsartikel (refereegranskat)abstract
- Early onset of conduct disorder (CD) with callous-unemotional traits has been linked to low levels of dopamine β-hydroxylase (DβH), an enzyme involved in dopamine turnover. The C1021T polymorphism in the DβH gene is a major quantitative-trait locus, regulating the level of DβH. In this study of juvenile delinquents from Northern Russia (n = 180), the polymorphism at -1021 was associated neither with early-onset CD nor with psychopathic traits. Association was found between psychopathic traits and early-onset CD, ADHD and mania.
|
|
