Search: WFRF:(Koppelman Gerard H.)
> (2020-2022)
> Davey Smith George >
Novel loci for chil...
Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits.
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Vogelezang, Suzanne (author)
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Bradfield, Jonathan P (author)
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Ahluwalia, Tarunveer S (author)
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show more...
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Curtin, John A (author)
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Lakka, Timo A (author)
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Grarup, Niels (author)
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Scholz, Markus (author)
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van der Most, Peter J (author)
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Monnereau, Claire (author)
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Stergiakouli, Evie (author)
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Heiskala, Anni (author)
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Horikoshi, Momoko (author)
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Fedko, Iryna O (author)
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Vilor-Tejedor, Natalia (author)
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Cousminer, Diana L (author)
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Standl, Marie (author)
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Wang, Carol A (author)
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Viikari, Jorma (author)
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Geller, Frank (author)
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Íñiguez, Carmen (author)
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Pitkänen, Niina (author)
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Chesi, Alessandra (author)
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- Bacelis, Jonas, 1984 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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Yengo, Loic (author)
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Torrent, Maties (author)
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Ntalla, Ioanna (author)
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Helgeland, Øyvind (author)
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Selzam, Saskia (author)
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Vonk, Judith M (author)
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Zafarmand, Mohammed H (author)
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Heude, Barbara (author)
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Farooqi, Ismaa Sadaf (author)
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Alyass, Akram (author)
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Beaumont, Robin N (author)
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Have, Christian T (author)
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Rzehak, Peter (author)
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Bilbao, Jose Ramon (author)
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Schnurr, Theresia M (author)
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Barroso, Inês (author)
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Bønnelykke, Klaus (author)
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Beilin, Lawrence J (author)
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Carstensen, Lisbeth (author)
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Charles, Marie-Aline (author)
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Chawes, Bo (author)
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Clément, Karine (author)
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Closa-Monasterolo, Ricardo (author)
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Custovic, Adnan (author)
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Eriksson, Johan G (author)
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Escribano, Joaquin (author)
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Groen-Blokhuis, Maria (author)
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Grote, Veit (author)
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Gruszfeld, Dariusz (author)
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Hakonarson, Hakon (author)
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Hansen, Torben (author)
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Hattersley, Andrew T (author)
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Hollensted, Mette (author)
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Hottenga, Jouke-Jan (author)
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Hyppönen, Elina (author)
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Johansson, Stefan (author)
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Joro, Raimo (author)
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Kähönen, Mika (author)
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Karhunen, Ville (author)
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Kiess, Wieland (author)
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Knight, Bridget A (author)
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Koletzko, Berthold (author)
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Kühnapfel, Andreas (author)
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Landgraf, Kathrin (author)
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Langhendries, Jean-Paul (author)
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Lehtimäki, Terho (author)
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Leinonen, Jaakko T (author)
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Li, Aihuali (author)
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Lindi, Virpi (author)
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Lowry, Estelle (author)
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Bustamante, Mariona (author)
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Medina-Gomez, Carolina (author)
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Melbye, Mads (author)
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Michaelsen, Kim F (author)
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Morgen, Camilla S (author)
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Mori, Trevor A (author)
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Nielsen, Tenna R H (author)
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Niinikoski, Harri (author)
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Oldehinkel, Albertine J (author)
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Pahkala, Katja (author)
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Panoutsopoulou, Kalliope (author)
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Pedersen, Oluf (author)
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Pennell, Craig E (author)
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Power, Christine (author)
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Reijneveld, Sijmen A (author)
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Rivadeneira, Fernando (author)
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Simpson, Angela (author)
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Sly, Peter D (author)
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Stokholm, Jakob (author)
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Teo, Kook K (author)
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Thiering, Elisabeth (author)
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Timpson, Nicholas J (author)
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Uitterlinden, André G (author)
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van Beijsterveldt, Catharina E M (author)
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van Schaik, Barbera D C (author)
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Vaudel, Marc (author)
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Verduci, Elvira (author)
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Vinding, Rebecca K (author)
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Vogel, Mandy (author)
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Zeggini, Eleftheria (author)
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Sebert, Sylvain (author)
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Lind, Mads V (author)
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Brown, Christopher D (author)
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Santa-Marina, Loreto (author)
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Reischl, Eva (author)
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Frithioff-Bøjsøe, Christine (author)
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Meyre, David (author)
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Wheeler, Eleanor (author)
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Ong, Ken (author)
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Nohr, Ellen A (author)
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Vrijkotte, Tanja G M (author)
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Koppelman, Gerard H (author)
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Plomin, Robert (author)
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Njølstad, Pål R (author)
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Dedoussis, George D (author)
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Froguel, Philippe (author)
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Sørensen, Thorkild I A (author)
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- Jacobsson, Bo, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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Freathy, Rachel M (author)
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Zemel, Babette S (author)
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Raitakari, Olli (author)
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Vrijheid, Martine (author)
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Feenstra, Bjarke (author)
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Lyytikäinen, Leo-Pekka (author)
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Snieder, Harold (author)
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Kirsten, Holger (author)
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Holt, Patrick G (author)
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Heinrich, Joachim (author)
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Widén, Elisabeth (author)
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Sunyer, Jordi (author)
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Boomsma, Dorret I (author)
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Järvelin, Marjo-Riitta (author)
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Körner, Antje (author)
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Davey Smith, George (author)
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Holm, Jens-Christian (author)
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Atalay, Mustafa (author)
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Murray, Clare (author)
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Bisgaard, Hans (author)
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McCarthy, Mark I (author)
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Jaddoe, Vincent W V (author)
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Grant, Struan F A (author)
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Felix, Janine F (author)
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(creator_code:org_t)
- 2020-10-12
- 2020
- English.
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In: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404. ; 16:10
- Related links:
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https://journals.plo...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Vogelezang, Suza ...
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Bradfield, Jonat ...
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Ahluwalia, Tarun ...
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Curtin, John A
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Lakka, Timo A
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Grarup, Niels
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show more...
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Scholz, Markus
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van der Most, Pe ...
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Monnereau, Clair ...
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Stergiakouli, Ev ...
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Heiskala, Anni
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Horikoshi, Momok ...
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Fedko, Iryna O
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Vilor-Tejedor, N ...
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Cousminer, Diana ...
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Standl, Marie
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Wang, Carol A
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Viikari, Jorma
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Geller, Frank
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Íñiguez, Carmen
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Pitkänen, Niina
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Chesi, Alessandr ...
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Bacelis, Jonas, ...
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Yengo, Loic
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Torrent, Maties
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Ntalla, Ioanna
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Helgeland, Øyvin ...
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Selzam, Saskia
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Vonk, Judith M
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Zafarmand, Moham ...
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Heude, Barbara
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Farooqi, Ismaa S ...
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Alyass, Akram
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Beaumont, Robin ...
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Have, Christian ...
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Rzehak, Peter
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Bilbao, Jose Ram ...
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Schnurr, Theresi ...
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Barroso, Inês
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Bønnelykke, Klau ...
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Beilin, Lawrence ...
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Carstensen, Lisb ...
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Charles, Marie-A ...
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Chawes, Bo
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Clément, Karine
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Closa-Monasterol ...
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Custovic, Adnan
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Eriksson, Johan ...
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Escribano, Joaqu ...
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Groen-Blokhuis, ...
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Grote, Veit
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Gruszfeld, Dariu ...
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Hakonarson, Hako ...
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Hansen, Torben
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Hattersley, Andr ...
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Hollensted, Mett ...
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Hottenga, Jouke- ...
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Hyppönen, Elina
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Johansson, Stefa ...
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Joro, Raimo
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Kähönen, Mika
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Karhunen, Ville
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Kiess, Wieland
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Knight, Bridget ...
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Koletzko, Bertho ...
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Kühnapfel, Andre ...
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Landgraf, Kathri ...
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Langhendries, Je ...
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Lehtimäki, Terho
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Leinonen, Jaakko ...
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Li, Aihuali
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Lindi, Virpi
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Lowry, Estelle
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Bustamante, Mari ...
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Medina-Gomez, Ca ...
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Melbye, Mads
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Michaelsen, Kim ...
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Morgen, Camilla ...
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Mori, Trevor A
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Nielsen, Tenna R ...
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Niinikoski, Harr ...
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Oldehinkel, Albe ...
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Pahkala, Katja
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Panoutsopoulou, ...
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Pedersen, Oluf
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Pennell, Craig E
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Power, Christine
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Reijneveld, Sijm ...
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Rivadeneira, Fer ...
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Simpson, Angela
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Sly, Peter D
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Stokholm, Jakob
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Teo, Kook K
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Thiering, Elisab ...
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Timpson, Nichola ...
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Uitterlinden, An ...
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van Beijsterveld ...
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van Schaik, Barb ...
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Vaudel, Marc
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Verduci, Elvira
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Vinding, Rebecca ...
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Vogel, Mandy
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Zeggini, Elefthe ...
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Sebert, Sylvain
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Lind, Mads V
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Brown, Christoph ...
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Santa-Marina, Lo ...
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Reischl, Eva
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Frithioff-Bøjsøe ...
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Meyre, David
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Wheeler, Eleanor
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Ong, Ken
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Nohr, Ellen A
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Vrijkotte, Tanja ...
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Koppelman, Gerar ...
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Plomin, Robert
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Njølstad, Pål R
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Dedoussis, Georg ...
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Froguel, Philipp ...
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Sørensen, Thorki ...
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Jacobsson, Bo, 1 ...
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Freathy, Rachel ...
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Zemel, Babette S
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Raitakari, Olli
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Vrijheid, Martin ...
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Feenstra, Bjarke
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Lyytikäinen, Leo ...
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Snieder, Harold
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Kirsten, Holger
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Holt, Patrick G
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Heinrich, Joachi ...
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Widén, Elisabeth
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Sunyer, Jordi
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Boomsma, Dorret ...
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Järvelin, Marjo- ...
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Körner, Antje
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Davey Smith, Geo ...
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Holm, Jens-Chris ...
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Atalay, Mustafa
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Murray, Clare
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Bisgaard, Hans
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McCarthy, Mark I
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Jaddoe, Vincent ...
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Grant, Struan F ...
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Felix, Janine F
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
- Articles in the publication
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PLoS genetics
- By the university
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University of Gothenburg