SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Kubo Michiaki) ;lar1:(gu)"

Sökning: WFRF:(Kubo Michiaki) > Göteborgs universitet

  • Resultat 1-2 av 2
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Kanoni, Stavroula, et al. (författare)
  • Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
  • 2022
  • Ingår i: Genome biology. - : Springer Science and Business Media LLC. - 1474-760X .- 1465-6906 .- 1474-7596. ; 23:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery.To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism.Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
  •  
2.
  • Locke, Adam E, et al. (författare)
  • Genetic studies of body mass index yield new insights for obesity biology.
  • 2015
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401
  • Tidskriftsartikel (refereegranskat)abstract
    • Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-2 av 2
Typ av publikation
tidskriftsartikel (2)
Typ av innehåll
refereegranskat (2)
Författare/redaktör
März, Winfried (2)
Salomaa, Veikko (2)
Lind, Lars (2)
Raitakari, Olli T (2)
Sattar, Naveed (2)
Campbell, Harry (2)
visa fler...
Ohlsson, Claes, 1965 (2)
Strachan, David P (2)
Deloukas, Panos (2)
North, Kari E. (2)
Wareham, Nicholas J. (2)
Zheng, Wei (2)
Kuusisto, Johanna (2)
Laakso, Markku (2)
McCarthy, Mark I (2)
Ridker, Paul M. (2)
Chasman, Daniel I. (2)
Demirkan, Ayse (2)
van Duijn, Cornelia ... (2)
Langenberg, Claudia (2)
Magnusson, Patrik K ... (2)
Pedersen, Nancy L (2)
Boehnke, Michael (2)
Mohlke, Karen L (2)
Zhao, Wei (2)
Saleheen, Danish (2)
Lehtimäki, Terho (2)
Thorleifsson, Gudmar (2)
Thorsteinsdottir, Un ... (2)
Stefansson, Kari (2)
Locke, Adam E. (2)
Verweij, Niek (2)
Mangino, Massimo (2)
Gieger, Christian (2)
Peters, Annette (2)
Martin, Nicholas G. (2)
Spector, Tim D. (2)
Kaprio, Jaakko (2)
Samani, Nilesh J. (2)
Jarvelin, Marjo-Riit ... (2)
Hattersley, Andrew T (2)
Mahajan, Anubha (2)
Walker, Mark (2)
Luan, Jian'an (2)
Gustafsson, Stefan (2)
Caulfield, Mark J. (2)
Munroe, Patricia B. (2)
Palmer, Colin N. A. (2)
Pramstaller, Peter P ... (2)
Wilson, James F. (2)
visa färre...
Lärosäte
Göteborgs universitet  (2)Ta bort avgränsningen
Uppsala universitet (2)
Lunds universitet (2)
Karolinska Institutet (2)
Umeå universitet (1)
Högskolan Dalarna (1)
Språk
Engelska (2)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (2)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy