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1.	Zylstra, J, et al. (author) Exercise prehabilitation during neoadjuvant chemotherapy may enhance tumour regression in oesophageal cancer: results from a prospective non-randomised trial 2022 In: British journal of sports medicine. - : BMJ. - 1473-0480 .- 0306-3674. ; 56:7, s. 402- Journal article (peer-reviewed)abstract There is increasing evidence for the use of exercise in cancer patients and data supporting enhanced tumour volume reduction following chemotherapy in animal models. To date, there is no reported histopathological evidence of a similar oncological benefit in oesophageal cancer.MethodsA prospective non-randomised trial compared a structured prehabilitation exercise intervention during neoadjuvant chemotherapy and surgery versus conventional best-practice for oesophageal cancer patients. Biochemical and body composition analyses were performed at multiple time points. Outcome measures included radiological and pathological markers of disease regression. Logistic regression calculated ORs with 95% CI for the likelihood of pathological response adjusting for chemotherapy regimen and chemotherapy delivery.ResultsComparison of the Intervention (n=21) and Control (n=19) groups indicated the Intervention group had higher rates of tumour regression (Mandard TRG 1–3 Intervention n=15/20 (75%) vs Control n=7/19 (36.8%) p=0.025) including adjusted analyses (OR 6.57; 95% CI 1.52 to 28.30). Combined tumour and node downstaging (Intervention n=9 (42.9%) vs Control n=3 (15.8%) p=0.089) and Fat Free Mass index were also improved (Intervention 17.8 vs 18.7 kg/m2; Control 16.3 vs 14.7 kg/m2, p=0.026). Differences in markers of immunity (CD-3 and CD-8) and inflammation (IL-6, VEGF, INF-y, TNFa, MCP-1 and EGF) were observed.ConclusionThe results suggest improved tumour regression and downstaging in the exercise intervention group and should prompt larger studies on this topic.Trial registration numberNCT03626610.
2.	Knight, WRC, et al. (author) Prediction of a positive circumferential resection margin at surgery following neoadjuvant chemotherapy for adenocarcinoma of the oesophagus 2019 In: BJS open. - : Oxford University Press (OUP). - 2474-9842. ; 3:6, s. 767-776 Journal article (peer-reviewed)
3.	Knight, W, et al. (author) Prehabilitation exercise before oesophagectomy: long-term follow-up of patients declining/withdrawing from the program 2023 In: The British journal of surgery. - 1365-2168. ; 110:12, s. 1668-1672 Journal article (peer-reviewed)
4.	Bott, RK, et al. (author) Adjuvant therapy following neoadjuvant chemotherapy and surgery for oesophageal adenocarcinoma in patients with clear resection margins 2021 In: Acta oncologica (Stockholm, Sweden). - 1651-226X. ; 60:5, s. 672-680 Journal article (peer-reviewed)
5.	Knight, W, et al. (author) Patterns of recurrence in oesophageal cancer following oesophagectomy in the era of neo-adjuvant chemotherapy 2017 In: BRITISH JOURNAL OF SURGERY. - : Oxford University Press (OUP). - 0007-1323. ; 1:6, s. 182- Conference paper (other academic/artistic)
6.	Bott, RK, et al. (author) Adjuvant therapy following oesophagectomy for adenocarcinoma in patients with a positive resection margin 2020 In: The British journal of surgery. - 1365-2168. ; 107:13, s. 1801-1810 Journal article (peer-reviewed)
7.	Bott, RK, et al. (author) Predicting response to neoadjuvant chemotherapy in patients with oesophageal adenocarcinoma 2021 In: Acta oncologica (Stockholm, Sweden). - 1651-226X. ; 60:12, s. 1629-1636 Journal article (peer-reviewed)
8.	Moore, JL, et al. (author) Effect of peri-operative chemotherapy regimen on survival in the treatment of locally advanced oesophago-gastric adenocarcinoma - A comparison of the FLOT and 'MAGIC' regimens 2022 In: European journal of cancer (Oxford, England : 1990). - : Elsevier BV. - 1879-0852 .- 0959-8049. ; 163, s. 180-188 Journal article (peer-reviewed)
9.	Moore, JL, et al. (author) Pathologic Lymph Node Regression After Neoadjuvant Chemotherapy Predicts Recurrence and Survival in Esophageal Adenocarcinoma: A Multicenter Study in the United Kingdom 2023 In: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. - 1527-7755. ; 41:28, s. 4522- Journal article (peer-reviewed)
10.	Moore, JL, et al. (author) ASO Visual Abstract: Clinical Relevance of the Tumor Location-Modified Lauren Classification System of Gastric Cancer in a Western Population 2022 In: ANNALS OF SURGICAL ONCOLOGY. - : Springer Science and Business Media LLC. - 1068-9265 .- 1534-4681. ; 29:6, s. 3921-3921 Journal article (other academic/artistic)

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Result 1-10 of 11

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Type of publication: journal article (10); conference paper (1)

Type of content: peer-reviewed (9); other academic/artistic (2)

Author/Editor: Lagergren, J (11); Maisey, N (11); Van Hemelrijck, ... (11)Undo refine; Kelly, M. (10); Davies, AR (9); Baker, CR (8); show more...; Gossage, JA (8); Zylstra, J (7); Santaolalla, A (5); Goh, V (4); Allum, WH (4); Cunningham, D (4); GREEN, M (4); Bott, RK (4); Knight, WRC (4); Griffin, N (4); Tham, G (4); Qureshi, A. (3); Beckmann, K (3); Smyth, EC (3); Gossage, J (3); Waters, J. (3); Baker, C (3); George, S. (2); Kumar, S (2); Davies, A (2); Mahadeva, U (2); Hill, M (2); Knight, W (2); Wilkinson, MJ (2); Sevitt, T (2); Walker, R. (1); Underwood, TJ (1); Fitzgerald, RC (1); Wulaningsih, W (1); Kamarajah, SK (1); Griffiths, EA (1); Evans, RPT (1); George, G (1); McEwen, R (1); Dunn, J (1); Landau, D. (1); Mcguigan, A (1); Zeki, S (1); McAddy, N (1); Yip, C (1); Russell, B (1); Douglas, R (1); Horne, J (1); Grabsch, HI (1); show less...

University: Karolinska Institutet (11)

Language: English (11)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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