| 1. |
- Jiao, Xiang, et al.
(författare)
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PHIP - a novel candidate breast cancer susceptibility locus on 6q14.1
- 2017
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Ingår i: Oncotarget. - : IMPACT JOURNALS LLC. - 1949-2553. ; 8:61, s. 102769-102782
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Tidskriftsartikel (refereegranskat)abstract
- Most non-BRCA1/2 breast cancer families have no identified genetic cause. We used linkage and haplotype analyses in familial and sporadic breast cancer cases to identify a susceptibility locus on chromosome 6q. Two independent genome-wide linkage analysis studies suggested a 3 Mb locus on chromosome 6q and two unrelated Swedish families with a LOD > 2 together seemed to share a haplotype in 6q14.1. We hypothesized that this region harbored a rare high-risk founder allele contributing to breast cancer in these two families. Sequencing of DNA and RNA from the two families did not detect any pathogenic mutations. Finally, 29 SNPs in the region were analyzed in 44,214 cases and 43,532 controls from BCAC, and the original haplotypes in the two families were suggested as low-risk alleles for European and Swedish women specifically. There was also some support for one additional independent moderate-risk allele in Swedish familial samples. The results were consistent with our previous findings in familial breast cancer and supported a breast cancer susceptibility locus at 6q14.1 around the PHIP gene.
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| 2. |
- Pape Møller, Anders, et al.
(författare)
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Interaction of climate change with effects of conspecific and heterospecific density on reproduction
- 2020
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Ingår i: Oikos. - : Wiley. - 0030-1299 .- 1600-0706. ; 129:12, s. 1807-1819
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Tidskriftsartikel (refereegranskat)abstract
- We studied the relationship between temperature and the coexistence of great tit Parus major and blue tit Cyanistes caeruleus, breeding in 75 study plots across Europe and North Africa. We expected an advance in laying date and a reduction in clutch size during warmer springs as a general response to climate warming and a delay in laying date and a reduction in clutch size during warmer winters due to density‐dependent effects. As expected, as spring temperature increases laying date advances and as winter temperature increases clutch size is reduced in both species. Density of great tit affected the relationship between winter temperature and laying date in great and blue tit. Specifically, as density of great tit increased and temperature in winter increased both species started to reproduce later. Density of blue tit affected the relationship between spring temperature and blue and great tit laying date. Thus, both species start to reproduce earlier with increasing spring temperature as density of blue tit increases, which was not an expected outcome, since we expected that increasing spring temperature should advance laying date, while increasing density should delay it cancelling each other out. Climate warming and its interaction with density affects clutch size of great tits but not of blue tits. As predicted, great tit clutch size is reduced more with density of blue tits as temperature in winter increases. The relationship between spring temperature and density on clutch size of great tits depends on whether the increase is in density of great tit or blue tit. Therefore, an increase in temperature negatively affected the coexistence of blue and great tits differently in both species. Thus, blue tit clutch size was unaffected by the interaction effect of density with temperature, while great tit clutch size was affected in multiple ways by these interactions terms.
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| 3. |
- Moller, Anders Pape, et al.
(författare)
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Clutch-size variation in Western Palaearctic secondary hole-nesting passerine birds in relation to nest box design
- 2014
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Ingår i: Methods in Ecology and Evolution. - 2041-210X. ; 5:4, s. 353-362
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Tidskriftsartikel (refereegranskat)abstract
- Secondary hole-nesting birds that do not construct nest holes themselves and hence regularly breed in nest boxes constitute important model systems for field studies in many biological disciplines with hundreds of scientists and amateurs involved. Those research groups are spread over wide geographic areas that experience considerable variation in environmental conditions, and researchers provide nest boxes of varying designs that may inadvertently introduce spatial and temporal variation in reproductive parameters. We quantified the relationship between mean clutch size and nest box size and material after controlling for a range of environmental variables in four of the most widely used model species in the Western Palaearctic: great tit Parus major, blue tit Cyanistes caeruleus, pied flycatcher Ficedula hypoleuca and collared flycatcher F.albicollis from 365 populations and 79610 clutches. Nest floor area and nest box material varied non-randomly across latitudes and longitudes, showing that scientists did not adopt a random box design. Clutch size increased with nest floor area in great tits, but not in blue tits and flycatchers. Clutch size of blue tits was larger in wooden than in concrete nest boxes. These findings demonstrate that the size of nest boxes and material used to construct nest boxes can differentially affect clutch size in different species. The findings also suggest that the nest box design may affect not only focal species, but also indirectly other species through the effects of nest box design on productivity and therefore potentially population density and hence interspecific competition.
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| 4. |
- Moller, Anders P., et al.
(författare)
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Variation in clutch size in relation to nest size in birds
- 2014
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Ingår i: Ecology and Evolution. - : Wiley. - 2045-7758. ; 4:18, s. 3583-3595
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Tidskriftsartikel (refereegranskat)abstract
- Nests are structures built to support and protect eggs and/or offspring from predators, parasites, and adverse weather conditions. Nests are mainly constructed prior to egg laying, meaning that parent birds must make decisions about nest site choice and nest building behavior before the start of egg-laying. Parent birds should be selected to choose nest sites and to build optimally sized nests, yet our current understanding of clutch size-nest size relationships is limited to small-scale studies performed over short time periods. Here, we quantified the relationship between clutch size and nest size, using an exhaustive database of 116 slope estimates based on 17,472 nests of 21 species of hole and non-hole-nesting birds. There was a significant, positive relationship between clutch size and the base area of the nest box or the nest, and this relationship did not differ significantly between open nesting and hole-nesting species. The slope of the relationship showed significant intraspecific and interspecific heterogeneity among four species of secondary hole-nesting species, but also among all 116 slope estimates. The estimated relationship between clutch size and nest box base area in study sites with more than a single size of nest box was not significantly different from the relationship using studies with only a single size of nest box. The slope of the relationship between clutch size and nest base area in different species of birds was significantly negatively related to minimum base area, and less so to maximum base area in a given study. These findings are consistent with the hypothesis that bird species have a general reaction norm reflecting the relationship between nest size and clutch size. Further, they suggest that scientists may influence the clutch size decisions of hole-nesting birds through the provisioning of nest boxes of varying sizes.
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| 5. |
- Culina, Antica, et al.
(författare)
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Connecting the data landscape of long-term ecological studies : The SPI-Birds data hub
- 2021
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Ingår i: Journal of Animal Ecology. - : John Wiley & Sons. - 0021-8790 .- 1365-2656. ; 90:9, s. 2147-2160
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Tidskriftsartikel (refereegranskat)abstract
- The integration and synthesis of the data in different areas of science is drastically slowed and hindered by a lack of standards and networking programmes. Long-term studies of individually marked animals are not an exception. These studies are especially important as instrumental for understanding evolutionary and ecological processes in the wild. Furthermore, their number and global distribution provides a unique opportunity to assess the generality of patterns and to address broad-scale global issues (e.g. climate change). To solve data integration issues and enable a new scale of ecological and evolutionary research based on long-term studies of birds, we have created the SPI-Birds Network and Database ()-a large-scale initiative that connects data from, and researchers working on, studies of wild populations of individually recognizable (usually ringed) birds. Within year and a half since the establishment, SPI-Birds has recruited over 120 members, and currently hosts data on almost 1.5 million individual birds collected in 80 populations over 2,000 cumulative years, and counting. SPI-Birds acts as a data hub and a catalogue of studied populations. It prevents data loss, secures easy data finding, use and integration and thus facilitates collaboration and synthesis. We provide community-derived data and meta-data standards and improve data integrity guided by the principles of Findable, Accessible, Interoperable and Reusable (FAIR), and aligned with the existing metadata languages (e.g. ecological meta-data language). The encouraging community involvement stems from SPI-Bird's decentralized approach: research groups retain full control over data use and their way of data management, while SPI-Birds creates tailored pipelines to convert each unique data format into a standard format. We outline the lessons learned, so that other communities (e.g. those working on other taxa) can adapt our successful model. Creating community-specific hubs (such as ours, COMADRE for animal demography, etc.) will aid much-needed large-scale ecological data integration.
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| 6. |
- Vaugoyeau, Marie, et al.
(författare)
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Interspecific variation in the relationship between clutch size, laying date and intensity of urbanization in four species of hole-nesting birds
- 2016
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Ingår i: Ecology and Evolution. - : Wiley. - 2045-7758. ; 6:16, s. 5907-5920
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Tidskriftsartikel (refereegranskat)abstract
- The increase in size of human populations in urban and agricultural areas has resulted in considerable habitat conversion globally. Such anthropogenic areas have specific environmental characteristics, which influence the physiology, life history, and population dynamics of plants and animals. For example, the date of bud burst is advanced in urban compared to nearby natural areas. In some birds, breeding success is determined by synchrony between timing of breeding and peak food abundance. Pertinently, caterpillars are an important food source for the nestlings of many bird species, and their abundance is influenced by environmental factors such as temperature and date of bud burst. Higher temperatures and advanced date of bud burst in urban areas could advance peak caterpillar abundance and thus affect breeding phenology of birds. In order to test whether laying date advance and clutch sizes decrease with the intensity of urbanization, we analyzed the timing of breeding and clutch size in relation to intensity of urbanization as a measure of human impact in 199 nest box plots across Europe, North Africa, and the Middle East (i.e., the Western Palearctic) for four species of hole-nesters: blue tits (Cyanistes caeruleus), great tits (Parus major), collared flycatchers (Ficedula albicollis), and pied flycatchers (Ficedula hypoleuca). Meanwhile, we estimated the intensity of urbanization as the density of buildings surrounding study plots measured on orthophotographs. For the four study species, the intensity of urbanization was not correlated with laying date. Clutch size in blue and great tits does not seem affected by the intensity of urbanization, while in collared and pied flycatchers it decreased with increasing intensity of urbanization. This is the first large-scale study showing a species-specific major correlation between intensity of urbanization and the ecology of breeding. The underlying mechanisms for the relationships between life history and urbanization remain to be determined. We propose that effects of food abundance or quality, temperature, noise, pollution, or disturbance by humans may on their own or in combination affect laying date and/or clutch size.
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| 7. |
- Morbidelli, A., et al.
(författare)
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Fossilized condensation lines in the Solar System protoplanetary disk
- 2016
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Ingår i: Icarus. - : Elsevier BV. - 0019-1035. ; 267, s. 368-376
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Tidskriftsartikel (refereegranskat)abstract
- The terrestrial planets and the asteroids dominant in the inner asteroid belt are water poor. However, in the protoplanetary disk the temperature should have decreased below water-condensation level well before the disk was photo-evaporated. Thus, the global water depletion of the inner Solar System is puzzling. We show that, even if the inner disk becomes cold, there cannot be direct condensation of water. This is because the snowline moves towards the Sun more slowly than the gas itself. Thus the gas in the vicinity of the snowline always comes from farther out, where it should have already condensed, and therefore it should be dry. The appearance of ice in a range of heliocentric distances swept by the snowline can only be due to the radial drift of icy particles from the outer disk. However, if a planet with a mass larger than 20 Earth mass is present, the radial drift of particles is interrupted, because such a planet gives the disk a super-Keplerian rotation just outside of its own orbit. From this result, we propose that the precursor of Jupiter achieved this threshold mass when the snowline was still around 3 AU. This effectively fossilized the snowline at that location. In fact, even if it cooled later, the disk inside of Jupiter's orbit remained ice-depleted because the flow of icy particles from the outer system was intercepted by the planet. This scenario predicts that planetary systems without giant planets should be much more rich in water in their inner regions than our system. We also show that the inner edge of the planetesimal disk at 0.7 AU, required in terrestrial planet formation models to explain the small mass of Mercury and the absence of planets inside of its orbit, could be due to the silicate condensation line, fossilized at the end of the phase of streaming instability that generated the planetesimal seeds. Thus, when the disk cooled, silicate particles started to drift inwards of 0.7. AU without being sublimated, but they could not be accreted by any pre-existing planetesimals.
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| 8. |
- Morbidelli, A., et al.
(författare)
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The great dichotomy of the Solar System: Small terrestrial embryos and massive giant planet cores
- 2015
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Ingår i: Icarus. - : Elsevier BV. - 0019-1035. ; 258, s. 418-429
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Tidskriftsartikel (refereegranskat)abstract
- The basic structure of the Solar System is set by the presence of low-mass terrestrial planets in its inner part and giant planets in its outer part. This is the result of the formation of a system of multiple embryos with approximately the mass of Mars in the inner disk and of a few multi-Earth-mass cores in the outer disk, within the lifetime of the gaseous component of the protoplanetary disk. What was the origin of this dichotomy in the mass distribution of embryos/cores? We show in this paper that the classic processes of runaway and oligarchic growth from a disk of planetesimals cannot explain this dichotomy, even if the original surface density of solids increased at the snowline. Instead, the accretion of drifting pebbles by embryos and cores can explain the dichotomy, provided that some assumptions hold true. We propose that the mass-flow of pebbles is two-times lower and the characteristic size of the pebbles is approximately ten times smaller within the snowline than beyond the snowline (respectively at heliocentric distance r < r(ice) and r > r(ice) where r(ice) is the snowline heliocentric distance), due to ice sublimation and the splitting of icy pebbles into a collection of chondrule-size silicate grains. In this case, objects of original sub-lunar mass would grow at drastically different rates in the two regions of the disk. Within the snowline these bodies would reach approximately the mass of Mars while beyond the snowline they would grow to similar to 20 Earth masses. The results may change quantitatively with changes to the assumed parameters, but the establishment of a clear dichotomy in the mass distribution of protoplanets appears robust provided that there is enough turbulence in the disk to prevent the sedimentation of the silicate grains into a very thin layer. (C) 2015 Elsevier Inc. All rights reserved.
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| 9. |
- Villenave, M., et al.
(författare)
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A Highly Settled Disk around Oph163131
- 2022
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 930:1
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Tidskriftsartikel (refereegranskat)abstract
- High dust density in the midplane of protoplanetary disks is favorable for efficient grain growth and can allow fast formation of planetesimals and planets, before disks dissipate. Vertical settling and dust trapping in pressure maxima are two mechanisms allowing dust to concentrate in geometrically thin and high-density regions. In this work, we aim to study these mechanisms in the highly inclined protoplanetary disk SSTC2D J163131.2-242627 (Oph 163131, i ?84°). We present new high-Angular-resolution continuum and 12CO ALMA observations of Oph 163131. The gas emission appears significantly more extended in the vertical and radial direction compared to the dust emission, consistent with vertical settling and possibly radial drift. In addition, the new continuum observations reveal two clear rings. The outer ring, located at ?100 au, is well-resolved in the observations, allowing us to put stringent constraints on the vertical extent of millimeter dust particles. We model the disk using radiative transfer and find that the scale height of millimeter-sized grains is 0.5 au or less at 100 au from the central star. This value is about one order of magnitude smaller than the scale height of smaller micron-sized dust grains constrained by previous modeling, which implies that efficient settling of the large grains is occurring in the disk. When adopting a parametric dust settling prescription, we find that the observations are consistent with a turbulent viscosity coefficient of about ? ?2 10-5 at 100 au. Finally, we find that the thin dust scale height measured in Oph 163131 is favorable for planetary growth by pebble accretion: A 10 M E planet may grow within less than 10 Myr, even in orbits exceeding 50 au.
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