| 1. |
- Aartsen, M. G., et al.
(författare)
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Very high-energy gamma-ray follow-up program using neutrino triggers from IceCube
- 2016
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Ingår i: Journal of Instrumentation. - 1748-0221 .- 1748-0221. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- We describe and report the status of a neutrino-triggered program in IceCube that generates real-time alerts for gamma-ray follow-up observations by atmospheric-Cherenkov telescopes (MAGIC and VERITAS). While IceCube is capable of monitoring the whole sky continuously, high-energy gamma-ray telescopes have restricted fields of view and in general are unlikely to be observing a potential neutrino-flaring source at the time such neutrinos are recorded. The use of neutrino-triggered alerts thus aims at increasing the availability of simultaneous multi-messenger data during potential neutrino flaring activity, which can increase the discovery potential and constrain the phenomenological interpretation of the high-energy emission of selected source classes (e. g. blazars). The requirements of a fast and stable online analysis of potential neutrino signals and its operation are presented, along with first results of the program operating between 14 March 2012 and 31 December 2015.
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| 2. |
- Koppisetty, Ashok Krishna Chaitanya, 1982, et al.
(författare)
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Computational studies on the interaction of ABO-active saccharides with the norovirus VA387 capsid protein can explain experimental binding data
- 2010
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Ingår i: Journal of Computer-Aided Molecular Design. - : Springer Science and Business Media LLC. - 0920-654X .- 1573-4951. ; 24:5, s. 423-431
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Tidskriftsartikel (refereegranskat)abstract
- Norovirus strains are known to cause recurring epidemics of winter vomiting disease. The crystal structure of the capsid protein of VA387, a representative of the clinically important GII.4 genocluster, was recently solved in complex with histo-blood group A- and B-trisaccharides. However, the VA387 strain is known to bind also to other natural carbohydrates for which detailed structural information of the complexes is not available. In this study we have computationally explored the fit of the VA387 with a set of naturally occurring carbohydrate ligands containing a terminal alpha 1,2-linked fucose. MD simulations both with explicit and implicit solvent models indicate that type 1 and 3 extensions of the ABO-determinant including ALe(b) and BLe(b) pentasaccharides can be well accommodated in the site. Scoring with Glide XP indicates that the downstream extensions of the ABO-determinants give an increase in binding strength, although the alpha 1,2-linked fucose is the single strongest interacting residue. An error was discovered in the geometry of the GalNAc-Gal moiety of the published crystal structure of the A-trisaccharide/VA387 complex. The present modeling of the complexes with histo-blood group A-active structures shows some contacts which provide insight into mutational data, explaining the involvement of I389 and Q331. Our results can be applicable in structure-based design of adhesion inhibitors of noroviruses.
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| 3. |
- Frey, Ashley E., et al.
(författare)
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Modeling alternatives for erosion control at Matagorda County, Texas, with Gencade
- 2012
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Ingår i: Proceedings of the Coastal Engineering Conference : 33rd International Conference on Coastal Engineering 2012 - 33rd International Conference on Coastal Engineering 2012.
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Konferensbidrag (refereegranskat)abstract
- Matagorda Peninsula and Sargent Beach, Texas, USA, have experienced some of the highest rates of erosion along the Texas coast. In order to increase protection from tropical events and slow beach habitat erosion, several structural alternatives were studied. These alternatives were modeled with GenCade, a newly developed 1D shoreline change and sand transport model. GenCade was calibrated and validated over the 60 miles of shoreline in Matagorda County. Then separate GenCade grids and simulations were conducted for the structural alternatives at Matagorda Peninsula and Sargent Beach. At Matagorda Peninsula, different groin lengths and spacing between groins were modeled with and without beach fills and mechanical bypassing. The alternatives at Sargent Beach included detached breakwaters, groins, and beach fills. Although the process described in this paper only includes a small part of a more detailed study, these simulations helped lead to a recommendation of the selected alternatives for preliminary engineering design.
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| 4. |
- Kehoe, Laura, et al.
(författare)
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Make EU trade with Brazil sustainable
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 5. |
- Larson, M.A., et al.
(författare)
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Growth rate dispersion in MSMPR crystallizers
- 1985
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Ingår i: AIChE Journal. - : Wiley. - 0001-1541 .- 1547-5905. ; 31:1, s. 90-94
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Tidskriftsartikel (refereegranskat)abstract
- A model is presented which relates the crystal size distribution (CSD) from a mixed-suspension, mixed-product-removal (MSMPR) crystallizer to the distribution of growth rates. This model is based on the assumption that individual contact nuclei have some inherent growth rate which remains constant, but the growth rate may vary from crystal to crystal. The crystal size distribution can be calculated from prior knowledge of the growth rate distribution. A limited knowledge of only the coefficient of variation and the mean growth rate permits an approximation of the expected crystal size distribution. Conversely, estimates of the mean and variance of the growth rate distribution can be determined from the moments of the CSD from an MSMPR crystallizer
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| 6. |
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