| 1. |
- Almstedt, Elin, 1988-, et al.
(författare)
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Integrative discovery of treatments for high-risk neuroblastoma
- 2020
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723 .- 2041-1723. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- Despite advances in the molecular exploration of paediatric cancers, approximately 50% of children with high-risk neuroblastoma lack effective treatment. To identify therapeutic options for this group of high-risk patients, we combine predictive data mining with experimental evaluation in patient-derived xenograft cells. Our proposed algorithm, TargetTranslator, integrates data from tumour biobanks, pharmacological databases, and cellular networks to predict how targeted interventions affect mRNA signatures associated with high patient risk or disease processes. We find more than 80 targets to be associated with neuroblastoma risk and differentiation signatures. Selected targets are evaluated in cell lines derived from high-risk patients to demonstrate reversal of risk signatures and malignant phenotypes. Using neuroblastoma xenograft models, we establish CNR2 and MAPK8 as promising candidates for the treatment of high-risk neuroblastoma. We expect that our method, available as a public tool (targettranslator.org), will enhance and expedite the discovery of risk-associated targets for paediatric and adult cancers.
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| 2. |
- Anderson, Johan, 1973-, et al.
(författare)
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Assessment of Self-Heating in Wood Pellets by FE Modelling
- 2017
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Konferensbidrag (refereegranskat)abstract
- The self-heating process in a laboratory scale experiment has been modelled using the Comsol Multiphysics software. In the simulations the gas flow and air movement in the volume and heat diffusion in the bulk were taken into account however only one reaction in the pellets bulk is considered. The input data is found from measurements of the reaction chemistry and the heat transfer properties. It is found that all relevant physics is needed in order to obtain reasonable predictions in particular the heat transfer between the bulk and the gas is important but also condensation and evaporation of moisture.
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| 3. |
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| 4. |
- Koppejan, Japp, et al.
(författare)
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Health and safety Aspects of Solid Biomass Storage, Transportation and Feeding
- 2013
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This publication focuses on the health and safety issues of the supply chain of solid biofuels with the objective to highlight commonly used mitigation methodologies to promote a better working environment when dealing with solid biofuels. It has been compiled as a joint effort by experts active in Tasks 32, 36, 37 and 40 of the IEA Bioenergy Agreement, with their own specific fields of expertise. Only through this cooperation, it was possible to touch upon the full range of issues in one publication that one may come across when developing projects in which solid biomass fuels are produced, traded or used. The properties of a biomass material and the intended use determine how the material should be safely transported and stored. Self-heating, off-gassing and dust explosions are significant challenges for the industry that have already resulted in significant losses of capital investments and even tragic loss of life. Likewise, exposure to biologically active material, such as moulds and spores may form a serious hazard for the health of workers involved. With the growth of the bioenergy sector, it is important not only that opportunities for bioenergy are implemented in an efficient economic manner, but also safely.
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| 5. |
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| 6. |
- Larsson, Ida, et al.
(författare)
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Assessment of the Self-heating Potential of Wood Pellets
- 2012
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The use of biomass pellets is increasing. As a consequence, large indoor storage facilities are needed along the transportation chain. The increased production volumes, transportation, handling and storage of pellets result in increased risks. A number of fire incidents due to spontaneous ignition in wood pellets have been reported. Increased efforts concerning safety and quality assurance are, therefore, important. The aim of the present work is to provide methods for estimating risks for self-heating from pellets stored in bulk quantities. The experimental work ranges from small-scale characterizations to medium-scale storage tests and includes several different types of pellets. One aim has been to develop small scale screening methods to assess the propensity for self-heating, thereby trying to define the specific type of “activity” occurring in the pellets as well as characterising it. Isothermal calorimetry (micro calorimeter) has been used as small scale screening test method and the results has then been validated with crossing point tests and in medium scale tests (1 m3). Thirteen samples from different types of pellets have been ranked relative to each other in micro calorimeter tests and two pellet types; one “reactive” and one “less reactive” were also tested for validation in crossing point and medium scale. The results clearly reveal that different activity levels of the pellets can be measured using small scale screening methods.
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| 7. |
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| 8. |
- Larsson, Ida, 1977-
(författare)
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Att översätta Lean till praktik i hälso- och sjukvården
- 2019
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Lean has been widely discussed and introduced in Sweden as well as internationally. This thesis deals with the question of how Lean has been translated from idea into practice in healthcare. It contributes to Scandinavian institutional theory, more specifically translation theory. The thesis shows how Lean is translated at the micro level, i.e. at two healthcare units that deal directly with patients. Lean is quite a broad and flexible management idea. In this thesis Lean has been specified into the central concepts of value and flow. The thesis focuses on how these concepts have been translated in healthcare, investigating the role of translators and arenas in local translation processes at the micro level. The thesis is based on a comparative case study of two healthcare units, at two different hospitals, within public healthcare. In 2009 the healthcare units started to implement Lean with the aim that they would improve patient flow and increase quality. The thesis includes a vast number of internal documents, interviews and observations. It also includes a follow-up of the two cases a few years after the initial interviews were carried out. The study presents a number of contributions. Analysis shows that the local translation process in each case resulted in a mutual adaptation between Lean and practice. Furthermore, the introduction of Lean didn´t change the work of the units completely. Lean was translated in a way that supported how the units were organized already before the introduction of Lean instead of changing them. The analysis also shows that the translation of Lean was not isolated within the healthcare units, but spilled over into and was influenced by the surrounding context, both to the private sphere and to other organizations. The findings indicate that translation is something that is going on everywhere, all the time and that the connection between the public and the private sphere, through conversations and small talk about Lean, can be a way of spreading and translating ideas. The introduction of Lean at the units started as a top-down process. But Lean was also translated horizontally to and from friends and family members who had met Lean in other contexts. The translators and arenas at the micro-level filled an important function in the way in which Lean was translated into practice in the operational core where small talk and discussions seemed to be important. But in addition to this the thesis also shows that an actor in a formal position is required to add energy and drive the work with Lean forward.
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| 9. |
- Larsson, Ida, 1978-, et al.
(författare)
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Development of a screening test based on isothermal calorimetry for determination of self-heating potential of biomass pellets
- 2017
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Ingår i: Fire and Materials. - : John Wiley & Sons. - 0308-0501 .- 1099-1018. ; , s. 1-13
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Tidskriftsartikel (refereegranskat)abstract
- For the risk for spontaneous combustion in storage of biomass pellets to be assessed, it is important to know how prone the fuel is to self-heating. There are traditional methods that are used to determine self-heating characteristics of fuels, eg, basket heating tests. The results from basket heating tests indirectly give the reactivity from a series of tests at high temperatures. This paper presents a sensitive screening test procedure for biomass pellets using isothermal calorimetry for direct measurement of the heat production rate at typical bulk storage temperatures. This method can be used to directly compare the reactivity of different batches of biomass pellets. The results could be used, eg, by storage security managers to gain better knowledge of their fuels propensity for self-heating and thereby for safer storage. A large number of tests have been performed to develop the test procedure presented. Different parameters, such as temperature, type of the test sample (powder/crushed or pellets), mass of test sample, and preheating time, have been varied. Furthermore, gas concentrations in the sample ampoule have been measured before and after some tests to study the oxygen consumption and the formation of CO and CO2. Three different types of pellets with different characteristics were tested to assess the variation in behaviour. Based on these tests, a screening test procedure is presented with a test temperature of 60°C, a sample size of 4 g, a 15-minute preheating period at the test temperature, and 24-hour test duration.
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| 10. |
- Larsson, Ida, 1979-
(författare)
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Measurement of Self-Heating of Biomass Pellets using Isothermal Calorimetry
- 2017
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Self-heating in storage facilities of biomass pellet can lead to spontaneous combustion. This has resulted in many fires over the years, causing both financial and environmental losses.In order to assess the risk for spontaneous combustion of biomass pellets during storage, it is important to know how prone the fuel is to self-heating, i.e. to determine its reactivity. This thesis presents experimental work performed to develop a sensitive screening test procedure for biomass pellets, using isothermal calorimetry for direct measurement of the heat production rate. This method can be used to compare the reactivity of different biomass pellets. This could be useful for e.g. facility owners to gain better knowledge of their fuels propensity for self-heating and thereby facilitate safer storage.The screening test procedure can also be used for research purposes. Experiments have been performed with 31 different biomass pellet batches to investigate how the pellet composition, origin, etc. influence the reactivity of the pellets. The results from these experiments clearly show a significant difference in reactivity between different types of pellets. The results indicate that pine/spruce mix pellets are significantly more reactive than all other types of pellets tested, and that pellets consisting of 100 % pine are more reactive than pellets consisting of 100 % spruce. Pellets produced from winery wastes, straw, or eucalyptus, have low reactivity compared to pellets consisting of pine and/or spruce. The reactivity of the pellets was shown to be reduced by either introducing certain types of anti-oxidants into the pellets or by extracting lipids from the raw material of pellets.The screening test procedure is already being used today by some facility owners for assessing their fuels propensity for self-heating. The procedure is also one of the suggested test methods in “ISO/CD 20049 Solid biofuels — Determination of self-heating of pelletized biofuels”.
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