Search: WFRF:(Lassen Jens Flensted)
> (2019)
> Pedersen Frants >
Unreported exclusio...
Unreported exclusion and sampling bias in interpretation of randomized controlled trials in patients with STEMI
-
- Laursen, Peter Nørkjær (author)
- Copenhagen University Hospital
-
- Holmvang, Lene (author)
- Copenhagen University Hospital
-
- Lønborg, Jacob (author)
- Copenhagen University Hospital
-
show more...
-
- Køber, Lars (author)
- Copenhagen University Hospital
-
- Høfsten, Dan E. (author)
- Copenhagen University Hospital
-
- Helqvist, Steffen (author)
- Copenhagen University Hospital
-
- Clemmensen, Peter (author)
- University of Southern Denmark,University Medical Center Hamburg-Eppendorf,Nykøbing Falster Hospital
-
- Kelbæk, Henning (author)
- Zealand University Hospital
-
- Jørgensen, Erik (author)
- Copenhagen University Hospital
-
- Lassen, Jens Flensted (author)
- Copenhagen University Hospital
-
- Pedersen, Frants (author)
- Copenhagen University Hospital
-
- Høi-Hansen, Thomas (author)
- Gentofte Hospital
-
- Raungaard, Bent (author)
- Aalborg University
-
- Terkelsen, Christian Juhl (author)
- Aarhus University Hospital
-
- Jensen, Lisette Okkels (author)
- Odense University Hospital
-
- Sadjadieh, Golnaz (author)
- Copenhagen University Hospital
-
- Engstrøm, Thomas (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Copenhagen University Hospital
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- English.
-
In: International Journal of Cardiology. - : Elsevier BV. - 0167-5273. ; 289, s. 1-5
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://findresearch...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Aims: To assess the impact of sampling bias due to reported as well as unreported exclusion of the target population in a multi-center randomized controlled trial (RCT)of ST-elevation myocardial infarction (STEMI). Methods and Results: We compared clinical characteristics and mortality between participants in the DANAMI-3 trial to contemporary non-participants with STEMI using unselected registries. A total of 179 DANAMI-3 participants (8%)and 617 contemporary non-participants (22%)had died (Log-Rank: P < 0.001)after a median follow-up of 1333 days (range: 1–2021 days). In an unadjusted Cox regression model all groups of non-participants had a higher hazard ratio to predict mortality compared to participants: eligible excluded (n = 144)(hazard ratio: 3.41 (95% CI: (2.69–4.32)), ineligible excluded (n = 472)(hazard ratio: 3.42 (95% CI: (2.44–4.80), eligible non-screened (n = 154)(hazard ratio: 3.37 (95% CI: (2.36–4.82)), ineligible non-screened (n = 154)(hazard ratio: 6.48 (95% CI: (4.77–8.80). Conclusion: Sampling bias had occurred due to both reported and unreported exclusion of eligible patients and the difference in mortality between participants and non-participants could not be explained only by the trial exclusion criteria. Thus, screening logs may not be suited to address the risks of sampling bias.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- External validity
- Randomized controlled trials
- Sampling bias
- Screening logs
- ST-elevation myocardial infarction
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Laursen, Peter N ...
-
Holmvang, Lene
-
Lønborg, Jacob
-
Køber, Lars
-
Høfsten, Dan E.
-
Helqvist, Steffe ...
-
show more...
-
Clemmensen, Pete ...
-
Kelbæk, Henning
-
Jørgensen, Erik
-
Lassen, Jens Fle ...
-
Pedersen, Frants
-
Høi-Hansen, Thom ...
-
Raungaard, Bent
-
Terkelsen, Chris ...
-
Jensen, Lisette ...
-
Sadjadieh, Golna ...
-
Engstrøm, Thomas
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
- Articles in the publication
-
International Jo ...
- By the university
-
Lund University