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Sökning: WFRF:(Law Ian) > Doktorsavhandling

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1.
  • Fällmar, David, 1980- (författare)
  • ­­­Visual assessment of perfusion and metabolism in neurodegenerative dementia
  • 2016
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • A worldwide demographic shift is currently occurring, with rapidly increasing numbers of elderly individuals. Since the incidence of neurodegenerative disease generally increases with age, this entails an increase in dementia prevalence. There are several strong incentives for establishing robust and widely available imaging methods for the early diagnosis of these diseases. Atrophy patterns are evident only late in the disease process, and the distinction from healthy ageing can often be elusive. For early diagnosis, physiologic parameters such as perfusion or metabolism must be assessed. The available modalities all have restricted clinical usefulness. The main aim of this thesis was to advance the clinical usefulness of perfusion and metabolism imaging in patients with neurodegenerative dementia, with a focus on visual assessment.A cohort of patients with neurodegenerative dementia was included, along with an age-matched control group. All subjects underwent MRI, including a pseudocontinuous ASL sequence and FDG-PET. In papers II and III, a subgroup containing both patients and controls underwent a second FDG-PET with reduced dose. In paper IV, the material was combined with a similar cohort from Amsterdam.Paper I showed that spatial smoothing increased the correlation between visually assessed perfusion and metabolism levels as displayed with FDG-PET. However, the distinction between patients and healthy controls was less satisfactory due to false positives.Paper II showed that differences in regional standard uptake value ratios between normal- and low-dose FDG-PET were small and without clinically significant bias.Paper III showed that the diagnostic performance of Z-score maps showing regions of significant deficits in metabolism was highly similar in normal- and low-dose FDG-PET images. Paper IV showed that ASL perfusion-based Z-score maps can be used for diagnostic purposes with high specificity, but inferior sensitivity, compared to FDG-PET.In conclusion, the included studies address aspects of the visual assessment of perfusion and metabolism neuroimaging, with a focus on clinical usefulness in diagnosing neurodegenerative dementia.
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2.
  • Zakharov, Nikolay, 1978- (författare)
  • Attaining Whiteness : A Sociological Study of Race and Racialization in Russia
  • 2013
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Attaining Whiteness is the first book-length sociological study of how ideas about race resonate in post-Soviet Russia. The book charts how tropes of self, hybridity, and maturity constitute important symbolic vehicles for applying the idea of race to the drawing of differences. A new theoretical framework is developed that casts light on fields of study that have not yet received sufficient attention in Western European and American research concerning racial issues. This study of racialization takes a step towards providing a better understanding of how the discourses of race are extended and transformed through the production of social knowledge and social relations. This volume addresses the resilience of genetic criteria for defining cultures and behaviors in both the sciences and humanities in Russia, and also examines the ongoing and pervasive policy of racialized exclusion. The study argues that the concepts and practices of race, whiteness, and Russianness operate ambivalently insofar as they both hold the social fabric together, organizing the perception of the “Other”, but also undermine the unity of society. Racialization thus fosters, first, the sense that Russia belongs to the core of civilization as opposed to the Third World; second, the formulation of policies towards the internal peripheries that support social control informed by the notion of human material; and, finally, the promotion of exclusionary ethnic self-identifications that employ the discourse of hybridity.
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