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- Leahy, M.J., et al.
(författare)
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Developments in laser Doppler blood perfusion monitoring
- 2002
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Ingår i: Proceedings of SPIE, the International Society for Optical Engineering. - : SPIE. - 0277-786X .- 1996-756X. ; 4876:1, s. 128-139
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- This paper reviews the development and use of laser Doppler perfusion monitors and imagers. Despite their great success and almost universal applicability in microcirculation research, they have had great difficulty in converting to widespread clinical application. The enormous interest in microvascular blood perfusion coupled with the 'ease of use' of the technique has led to 2000+ publications citing its use. However, useful results can only be achieved with an understanding of the basic principles of the instrumentation and its application in the various clinical disciplines. The basic technical background is explored and definitions of blood perfusion and laser Doppler perfusion are established. The calibration method is then described together with potential routes to standardisation. A guide to the limitations in application of the technique gives the user a clear indication of what can be achieved in new studies as well as possible inadequacy in some published investigations. Finally some clinical applications have found acceptability and these will be explored.
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- Das, Nandan, 1983-, et al.
(författare)
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Characterization of nano sensitive sub-micron scale tissue-structural multifractality and its alteration in tumor progress
- 2020
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Ingår i: Dynamics and Fluctuations in Biomedical Photonics XVII. - : SPIE - International Society for Optical Engineering. - 9781510632417 - 9781510632424
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Konferensbidrag (refereegranskat)abstract
- Assessment of disease using OCT is an actively investigated problem, owing to many unresolved challenges in early disease detection, diagnosis and treatment response monitoring. The spatial scale to which the information can be obtained from the scattered light is limited by the diffraction limit (~λ/2; λ = wavelength of light is typically in the micron level) and the axial resolution of OCT systems is limited by the inverse of spectral bandwidth. Yet, onset or progression of disease /precancer is typically associated with subtle alterations in the tissue dielectric and its ultra-structural morphology. On the other hand, biological tissue is known to have ultra-structural multifractality. For both the fundamental study of biological processes and early diagnosis of pathological processes, information on the nanoscale in the tissue sub-micron structural morphology is crucial. Therefore, we have developed a novel spectroscopic and label-free 3D OCT system with nanoscale sensitivity in combination of multifractal analysis for extraction and quantification of tissue ultra-structural multifractal parameters. This present approach demonstrated its capability to measure nano-sensitive tissue ultra-structural multifractality. In an initial study, we found that nano-sensitive sub-micron structural multifractality changes in transition from healthy to tumor in pathologically characterized fresh tissue samples. This novel method for extraction of nanosensitive tissue multifractality promises to develop a non-invasive diagnosis tool for early cancer detection.
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