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Sökning: WFRF:(Lecuit Marc)

  • Resultat 1-4 av 4
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  • El Zowalaty, Mohamed E., et al. (författare)
  • Draft Genome Sequence of Listeria innocua Strain MEZLIS29, Isolated from a Cow in South Africa
  • 2022
  • Ingår i: Microbiology Resource Announcements. - : American Society for Microbiology. - 2576-098X. ; 11:3
  • Tidskriftsartikel (refereegranskat)abstract
    • Here, we report the draft genome sequence of Listeria innocua strain MEZLIS29, which was isolated from a healthy cow in Flagstaff, Eastern Cape Province, South Africa. The genome was sequenced using the Illumina MiSeq platform and had a length of 2,805,865 bp, with a G+C content of 37.5% and 2,783 coding DNA sequences, 58 tRNAs, 4 noncoding RNAs, and 8 rRNA genes.
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3.
  • El Zowalaty, Mohamed E., et al. (författare)
  • Genome Sequence of Listeria innocua Strain MEZLIS26, Isolated from a Goat in South Africa
  • 2019
  • Ingår i: Microbiology Resource Announcements. - 2576-098X. ; 8:44
  • Tidskriftsartikel (refereegranskat)abstract
    • Here, we report the draft genome sequence of Listeria innocua strain MEZLIS26, isolated from a healthy goat in Flagstaff, Eastern Cape Province, South Africa. The genome was sequenced using the Illumina MiSeq platform and had a length of 2,800,777 bp, with a G+C content of 37.4%, 2,755 coding DNA sequences (CDSs), 49 transfer RNAs (tRNAs), and 4 noncoding RNAs (ncRNAs).
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4.
  • Toledo-Arana, Alejandro, et al. (författare)
  • The Listeria transcriptional landscape from saprophytism to virulence
  • 2009
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 459:7249, s. 950-956
  • Tidskriftsartikel (refereegranskat)abstract
    • The bacterium Listeria monocytogenes is ubiquitous in the environment and can lead to severe food-borne infections. It has recently emerged as a multifaceted model in pathogenesis. However, how this bacterium switches from a saprophyte to a pathogen is largely unknown. Here, using tiling arrays and RNAs from wild-type and mutant bacteria grown in vitro, ex vivo and in vivo, we have analysed the transcription of its entire genome. We provide the complete Listeria operon map and have uncovered far more diverse types of RNAs than expected: in addition to 50 small RNAs (<500 nucleotides), at least two of which are involved in virulence in mice, we have identified antisense RNAs covering several open-reading frames and long overlapping 5' and 3' untranslated regions. We discovered that riboswitches can act as terminators for upstream genes. When Listeria reaches the host intestinal lumen, an extensive transcriptional reshaping occurs with a SigB-mediated activation of virulence genes. In contrast, in the blood, PrfA controls transcription of virulence genes. Remarkably, several non-coding RNAs absent in the non-pathogenic species Listeria innocua exhibit the same expression patterns as the virulence genes. Together, our data unravel successive and coordinated global transcriptional changes during infection and point to previously unknown regulatory mechanisms in bacteria.
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  • Resultat 1-4 av 4

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