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Träfflista för sökning "WFRF:(Lehtovirta Mikko) ;pers:(Lindgren Cecilia)"

Sökning: WFRF:(Lehtovirta Mikko) > Lindgren Cecilia

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1.
  • Parker, Alex, et al. (författare)
  • A gene conferring susceptibility to type 2 diabetes in conjunction with obesity is located on chromosome 18p11
  • 2001
  • Ingår i: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 50:3, s. 675-680
  • Tidskriftsartikel (refereegranskat)abstract
    • Genome-wide nonparametric linkage analysis of 480 sib-pairs affected with type 2 diabetes revealed linkage to a previously unreported susceptibility locus on chromosome 18p11. This result improved with stringent subphenotyping using age- and sex-adjusted BMI, ultimately reaching a logarithm of odds of 3.82 (allele sharing 0.6654) at a point between markers D18S976 and D18S391 when the most obese 20% of the sample was analyzed. Several genes on chromosome 18 have been suggested as metabolic disease candidates, but none of these colocalize with our linkage result. We conclude that our results provide support for the presence of a currently uncharacterized gene on chromosome 18p, certain alleles of which confer increased susceptibility to type 2 diabetes in conjunction with obesity. We additionally observed moderate evidence for linkage to chromosome 1, near marker D1S3462; chromosome 4, near marker D4S2361; chromosome 5, near marker D5S1505; and chromosome 17, near marker D17S1301.
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2.
  • Ström, Kristoffer, et al. (författare)
  • Genetic variation at RAB3GAP2 and its role in exercise-related adaptation and recovery
  • 2021
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • Skeletal muscle fiber composition and capillary density influence physical performance and whole-body metabolic properties. ~45% of the variance in fiber type is heritable, which motivated us to perform a genome-wide association study of skeletal muscle histology from 656 Swedish men. Four independent variants were associated (p
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