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Blood Metabolic Sig...
Blood Metabolic Signatures of Body Mass Index : A Targeted Metabolomics Study in the EPIC Cohort
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- Carayol, Marion (författare)
- International Agency for Research on Cancer, World Health Organization
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- Leitzmann, Michael F. (författare)
- International Agency for Research on Cancer, World Health Organization
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- Ferrari, Pietro (författare)
- International Agency for Research on Cancer, World Health Organization
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- Zamora-Ros, Raul (författare)
- International Agency for Research on Cancer, World Health Organization
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- Achaintre, David (författare)
- International Agency for Research on Cancer, World Health Organization
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- Stepien, Magdalena (författare)
- International Agency for Research on Cancer, World Health Organization
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- Schmidt, Julie A (författare)
- University of Oxford
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- Travis, Ruth C (författare)
- University of Oxford
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- Overvad, Kim (författare)
- Aarhus University
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- Tjønneland, Anne (författare)
- Danish Cancer Society
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- Hansen, Louise (författare)
- Danish Cancer Society
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- Kaaks, Rudolf (författare)
- German Cancer Research Centre
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- Kühn, Tilman (författare)
- German Cancer Research Centre
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- Boeing, Heiner (författare)
- German Institute of Human Nutrition
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- Bachlechner, Ursula (författare)
- German Institute of Human Nutrition
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- Trichopoulou, Antonia (författare)
- Hellenic Health Foundation, Athens,Harvard University,National and Kapodistrian University of Athens
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- Bamia, Christina (författare)
- Hellenic Health Foundation, Athens,National and Kapodistrian University of Athens
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- Palli, Domenico (författare)
- Cancer Research and Prevention Institute (ISPO)
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- Agnoli, Claudia (författare)
- Istituto Nazionale dei Tumori
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- Tumino, Rosario (författare)
- Civic and M.P Arezzo Hospital
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- Vineis, Paolo (författare)
- Imperial College London
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- Panico, Salvatore (författare)
- University of Naples Federico II
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- Quirós, J Ramón (författare)
- Public Health Directorate
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- Sánchez-Cantalejo, Emilio (författare)
- Andalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP)
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- Huerta, José María (författare)
- CIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council
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- Ardanaz, Eva (författare)
- CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)
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- Arriola, Larraitz (författare)
- CIBER Epidemiology and Public Health (CIBERESP)
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- Agudo, Antonio (författare)
- Catalan Institute of Oncology
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- Nilsson, Jan (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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- Melander, Olle (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Bueno de Mesquita, Bas (författare)
- University Medical Center Utrecht,Imperial College London,University of Malaya,National Institute for Public Health and the Environment (RIVM)
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- Peeters, Petra H. (författare)
- Imperial College London,University Medical Center Utrecht
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- Wareham, Nick (författare)
- University of Cambridge
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- Khaw, Kay-Tee (författare)
- University of Cambridge
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- Jenab, Mazda (författare)
- International Agency for Research on Cancer, World Health Organization
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- Key, Timothy J (författare)
- University of Oxford
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- Scalbert, Augustin (författare)
- International Agency for Research on Cancer, World Health Organization
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- Rinaldi, Sabina (författare)
- International Agency for Research on Cancer, World Health Organization
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(creator_code:org_t)
- 2017-08-11
- 2017
- Engelska 10 s.
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Ingår i: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 16:9, s. 3137-3146
- Relaterad länk:
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http://dx.doi.org/10...
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https://europepmc.or...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Metabolomics is now widely used to characterize metabolic phenotypes associated with lifestyle risk factors such as obesity. The objective of the present study was to explore the associations of body mass index (BMI) with 145 metabolites measured in blood samples in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Metabolites were measured in blood from 392 men from the Oxford (UK) cohort (EPIC-Oxford) and in 327 control subjects who were part of a nested case-control study on hepatobiliary carcinomas (EPIC-Hepatobiliary). Measured metabolites included amino acids, acylcarnitines, hexoses, biogenic amines, phosphatidylcholines, and sphingomyelins. Linear regression models controlled for potential confounders and multiple testing were run to evaluate the associations of metabolite concentrations with BMI. 40 and 45 individual metabolites showed significant differences according to BMI variations, in the EPIC-Oxford and EPIC-Hepatobiliary subcohorts, respectively. Twenty two individual metabolites (kynurenine, one sphingomyelin, glutamate and 19 phosphatidylcholines) were associated with BMI in both subcohorts. The present findings provide additional knowledge on blood metabolic signatures of BMI in European adults, which may help identify mechanisms mediating the relationship of BMI with obesity-related diseases.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- blood
- body mass index
- metabolic profiling
- obesity
- targeted metabolome
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Carayol, Marion
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Leitzmann, Micha ...
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Ferrari, Pietro
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Zamora-Ros, Raul
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Achaintre, David
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Stepien, Magdale ...
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visa fler...
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Schmidt, Julie A
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Travis, Ruth C
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Overvad, Kim
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Tjønneland, Anne
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Hansen, Louise
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Kaaks, Rudolf
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Kühn, Tilman
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Boeing, Heiner
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Bachlechner, Urs ...
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Trichopoulou, An ...
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Bamia, Christina
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Palli, Domenico
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Agnoli, Claudia
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Tumino, Rosario
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Vineis, Paolo
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Panico, Salvator ...
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Quirós, J Ramón
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Sánchez-Cantalej ...
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Huerta, José Mar ...
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Ardanaz, Eva
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Arriola, Larrait ...
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Agudo, Antonio
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Nilsson, Jan
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Melander, Olle
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Bueno de Mesquit ...
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Peeters, Petra H ...
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Wareham, Nick
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Khaw, Kay-Tee
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Jenab, Mazda
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Key, Timothy J
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Scalbert, August ...
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Rinaldi, Sabina
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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Journal of Prote ...
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Lunds universitet