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| 2. |
- Lasselin, Julie, et al.
(författare)
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Biological motion during inflammation in humans
- 2020
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Ingår i: Brain, behavior, and immunity. - : Elsevier BV. - 0889-1591 .- 1090-2139. ; 84, s. 147-153
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Tidskriftsartikel (refereegranskat)abstract
- Biological motion is a powerful perceptual cue that can reveal important information about the inner state of an individual. Activation of inflammatory processes likely leads to changes in gait, posture, and mobility patterns, but the specific characteristics of inflammation-related biological motion have not been characterized. The aim of this study was to determine the effect of inflammation on gait and motion in humans. Systemic inflammation was induced in 19 healthy volunteers with an intravenous injection of lipopolysaccharide (2 ng/kg body weight). Biological motion parameters (walking speed, stride length and time, arm, leg, head, and shoulder angles) were assessed during a walking paradigm and the timed-up-and-go test. Cytokine concentrations, body temperature, and sickness symptoms were measured. During inflammation, compared to placebo, participants exhibited shorter, slower, and wider strides, less arm extension, less knee flexion, and a more downward-tilting head while walking. They were also slower and took a shorter First step in the timed-up-and-go test. Higher interleukin-6 concentrations, stronger sickness symptoms, and lower body temperature predicted the inflammation-related alterations in biological motion. These findings show that biological motion contains clear information about the inflammatory status of an individual, and may be used by peers or artificial intelligence to recognize that someone is sick or contagious.
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| 3. |
- Hedman, Erik, et al.
(författare)
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Mediators in psychological treatment of social anxiety disorder: Individual cognitive therapy compared to cognitive behavioral group therapy
- 2013
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Ingår i: Behaviour Research and Therapy. - : Elsevier. - 0005-7967 .- 1873-622X. ; 51:10, s. 696-705
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Tidskriftsartikel (refereegranskat)abstract
- According to cognitive-behavioral models of social anxiety disorder (SAD), four of the important maintaining mechanisms are avoidance, self-focused attention, anticipatory processing and post-event cognitive processing. Individual cognitive therapy (ICT) and cognitive behavioral group therapy (CBGT) both have substantial empirical support. However, it is unclear whether they achieve their effects by similar or different mechanisms. The aim of this study was to investigate whether changes in the four maintenance processes mediate clinical improvement in la and CBGT for SAD. We analyzed data from participants (N = 94) who received either ICT or CBGT in two separate RCTs. The results showed that ICT had larger effects than CBGT on social anxiety and each of the four potential mediators. More pertinently, moderated mediation analyses revealed significant between-treatment differences. Whereas improvement in ICT was mainly mediated by reductions in avoidance and self-focused attention, improvement in CBGT was mediated by changes in self-focused attention and in anticipatory and post-event processing. These results support the importance of the putative mediators, but suggest that their relative weights are moderated by treatment type.
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| 4. |
- Kemani, M. K., et al.
(författare)
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Processes of change in Acceptance and Commitment Therapy and Applied Relaxation for long-standing pain
- 2016
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Ingår i: European Journal of Pain. - : Wiley. - 1090-3801 .- 1532-2149. ; 20:4, s. 521-531
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The utility of cognitive behavioural (CB) interventions for chronic pain has been supported in numerous studies. This includes Acceptance and Commitment Therapy (ACT), which has gained increased empirical support. Previous research suggests that improvements in pain catastrophizing and psychological inflexibility are related to improvements in treatment outcome in this type of treatment. Although a few studies have evaluated processes of change in CB-interventions, there is a particular need for mediation analyses that use multiple assessments to model change in mediators and outcome over time, and that incorporate the specified timeline between mediator and outcome in the data analytic model.METHODS: This study used session-to-session assessments to evaluate if psychological inflexibility, catastrophizing, and pain intensity mediated the effects of treatment on pain interference. Analyses were based on data from a previously conducted randomized controlled trial (n = 60) evaluating the efficacy of ACT and Applied Relaxation (AR). A moderated mediation model based on linear mixed models was used to analyse the data.RESULTS: Neither catastrophizing nor pain intensity mediated changes in pain interference for any of the treatments. In contrast, psychological inflexibility mediated effects on outcome in ACT but not in AR.CONCLUSIONS: Results add to previous findings illustrating the role of psychological inflexibility as a mediator in ACT.
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| 5. |
- Hansson, Lina S., 1986-, et al.
(författare)
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Pointing out sickness : Detection of sickness from gait patterns
- 2021
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Ingår i: Brain, behavior, and immunity. - : Elsevier BV. - 0889-1591 .- 1090-2139. ; 98, s. 21-21
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Background: The ability to detect sick individuals is crucial for survival, by allowing avoidance of contagion. We have shown that humans can detect sick individuals from facial cues and body odors, but perception of these cues requires close proximity to the infectious person. Given that gait patterns can be detected from a distance and are altered during sickness, it would be beneficial to detect sickness from biological motion. Methods: We collected videos and point-light displays of walking individuals who were either made sick experimentally with an injection of lipopolysaccharide, or who were healthy (placebo). In study 1, 106 naive subjects watched these displays and rated them as coming from someone sick or healthy. In study 2, 106 other subjects rated health, sadness and tiredness of the displays on a VAS scale. Results: In Study 1, the sensitivity was 59% for videos and 57% for point-light displays, while the specificity was 74% for videos and 61% for point-light displays. Additional results will be presented at the conference. Conclusion: This study will indicate if sickness can be detected from gait patterns, possibly adding to immune defensive behaviors by facilitating avoidance of contagious peers.
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| 6. |
- Hansson, Lina S., et al.
(författare)
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The walking sick : Perception of experimental sickness from biological motion
- 2023
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Ingår i: Brain, behavior, and immunity. - : Elsevier. - 0889-1591 .- 1090-2139. ; 113, s. 319-327
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Tidskriftsartikel (refereegranskat)abstract
- Identification of sick conspecifics allows for avoidance of infectious threats, and is therefore an important behavioral defense against diseases. Here, we investigated if humans can identify sick individuals solely from biological motion and posture (using point-light displays). Additionally, we sought to determine which movements and sickness parameters would predict such detection. We collected video clips and derived point-light displays (one stride presented in a loop) of sick walkers (injected with lipopolysaccharide at 2.0 ng/kg body weight) and the same walkers when healthy (injected with saline). We then presented these displays to two groups, one group classified each walker as sick or healthy (study 1, n = 106), and the other group scored the walkers’ health on a visual analogue scale (study 2, n = 106). The raters were able to identify sick individuals above chance, and rated sick walkers as having worse health, both from observing video clips and point-light displays. Furthermore, both sickness detection and worse apparent health were predicted by inflammation-induced increase in rigidity and slower walking, but not other cues. Altogether, these findings indicate that biological motion can serve as a sickness cue, possibly allowing humans to identify sick conspecifics from a distance, and thereby allowing for disease avoidance.
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| 7. |
- Hedman, Erik, et al.
(författare)
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Sudden gains in internet-based cognitive behaviour therapy for severe health anxiety
- 2014
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Ingår i: Behaviour Research and Therapy. - : Elsevier. - 0005-7967 .- 1873-622X. ; 54, s. 22-29
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: A sudden gain is defined as a large and stable individual improvement occurring between two consecutive treatment sessions. Sudden gains have been shown to predict better long-term improvement in several treatment studies, including cognitive behavioural therapy for depression and anxiety disorders, but have not been studied in the treatment of health anxiety or any form of internet-based cognitive behavioural therapy. The aim of this study was to investigate the role of sudden gains in internet-based cognitive behavioural therapy for severe health anxiety.METHOD: We examined the occurrence and significance of sudden gains in measures of health anxiety in 81 participants receiving internet-based cognitive behavioural therapy. We compared patients with sudden gains, patients without sudden gains, and patients with gradual gains.RESULTS: Thirteen participants (16%) experienced one sudden gain in health anxiety with individual sudden gains distributed across the treatment. As expected, patients with a sudden gain showed larger improvements than patients without a sudden gain at post-treatment (d = 1.04) and at one-year follow-up (d = 0.91) on measures of health anxiety.CONCLUSIONS: Consistent with previous studies, sudden gains in internet-based cognitive behavioural therapy are associated with significantly larger and stable treatment effects up to one-year follow-up.
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| 8. |
- Hoesli, M., et al.
(författare)
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Real Estate in the Institutional Portfolio : A Comparison of Suggested and Actual Weights
- 2003
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Ingår i: The Journal of Alternative Investments. - 1520-3255 .- 2168-8435. ; 6:3, s. 53-59
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Tidskriftsartikel (refereegranskat)abstract
- The main objective of this study is to provide international evidence on the discrepancy between suggested and actual allocations to real estate in institutional portfolios, and also to discuss possible reasons for the discrepancy. We use data for the U.S., U.K., Sweden, and Switzerland to investigate the benefits of including real estate assets? both domestic and international? in institutional portfolios. The optimal allocation to real estate is found to be 15% to 20%, and is remarkably stable across countries. The suggested allocations to real estate in institutional portfolios are then compared with the actual institutional holdings in these four countries. The latter are found to be much less than the former, and some possible explanations for the discrepancy are given. The study also reports a substantial home bias in institutional real estate portfolios.
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| 9. |
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| 10. |
- Lasselin, Julie, 1986-, et al.
(författare)
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Advantages and methodological considerations of experimental endotoxemia in humans : Towards a standardized procedure for its application in PNI
- 2021
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Ingår i: Brain, behavior, and immunity. - : Elsevier BV. - 0889-1591 .- 1090-2139. ; 98, s. 28-29
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Tidskriftsartikel (refereegranskat)abstract
- Experimental endotoxemia is now recognized as a highly useful tool to better understand inflammation-induced behavioral changes and their underlying mechanisms. Advantages of this model include the ability to assess the causal effects of inflammatory mediators in a safe and highly controlled context, to assess the homeostatic (regulatory) response to inflammatory mediators within a relatively short time frame, as well as to translate findings between animals and humans. Various groups have used this model in humans, leading to variations in experimental procedures that likely affect the studied outcomes. As the use of experimental endotoxemia develops, there is a need of a standardization of the procedure to make the best use of this model in PNI. The participants in this discussion group are all leaders in the use of the model of experimental endotoxemia in humans in PNI, and will discuss the advantages, limitations, clinical relevance, and methodological considerations of this model. This discussion is intended as a first step towards developing common and optimized procedures for the use of this model across PNI groups.
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