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Individual variatio...
Individual variations in 'brain age' relate to early-life factors more than to longitudinal brain change
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- Vidal-Pineiro, Didac (author)
- Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
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- Wang, Yunpeng (author)
- Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
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- Krogsrud, Stine K. (author)
- Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
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- Amlien, Inge K. (author)
- Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
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- Baaré, William FC (author)
- Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital-Amager and Hvidovre, Copenhagen, Denmark
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- Bartres-Faz, David (author)
- Department of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain
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- Bertram, Lars (author)
- Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Lubeck, Germany
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- Brandmaier, Andreas M. (author)
- Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany; Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
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- Drevon, Christian A. (author)
- Department of Nutrition, Inst Basic Med Sciences, Faculty of Medicine, University of Oslo & Vitas Ltd, Oslo, Norway
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- Düzel, Sandra (author)
- Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
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- Ebmeier, Klaus (author)
- Department of Psychiatry, University of Oxford, Oxford, United Kingdom
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- Henson, Richard N. (author)
- MRC Cognition and Brain Sciences Unit and Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
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- Junqué, Carme (author)
- Department of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain
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- Kievit, Rogier Andrew (author)
- MRC Cognition and Brain Sciences Unit and Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom; Cognitive Neuroscience Department, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, Netherlands
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- Kühn, Simone (author)
- Lise Meitner Group for Environmental Neuroscience, Max Planck Institute for Human Development, Berlin, Germany; Department of Psychiatry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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- Leonardsen, Esten (author)
- Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
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- Lindenberger, Ulman (author)
- Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany; Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
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- Madsen, Kathrine S. (author)
- Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital-Amager and Hvidovre, Copenhagen, Denmark; Radiography, Department of Technology, University College Copenhagen, Copenhagen, Denmark
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- Magnussen, Fredrik (author)
- Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
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- Mowinckel, Athanasia Monika (author)
- Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
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- Nyberg, Lars, 1966- (author)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Fysiologi,Diagnostisk radiologi
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- Roe, James M. (author)
- Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
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- Segura, Barbara (author)
- Department of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain
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- Smith, Stephen M. (author)
- Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
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- Sørensen, Øystein (author)
- Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
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- Suri, Sana (author)
- Wellcome Centre for Integrative Neuroimaging (WIN FMRIB), University of Oxford, Oxford, United Kingdom; Wellcome Centre for Integrative Neuroimaging, Departments of Psychiatry and Clinical Neuroscience, University of Oxford, Oxford, United Kingdom
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- Westerhausen, Rene (author)
- Section for Cognitive Neuroscience and Neuropsychology, Department of Psychology, University of Oslo, Oslo, Norway
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- Zalesky, Andrew (author)
- Department of Biomedical Engineering, Faculty of Engineering and IT, The University of Melbourne, Melbourne, Australia
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- Zsoldos, Enikő (author)
- Wellcome Centre for Integrative Neuroimaging, Departments of Psychiatry and Clinical Neuroscience, University of Oxford, Oxford, United Kingdom
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- Walhovd, Kristine Beate (author)
- Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway; Department of radiology and nuclear medicine, Oslo University Hospital, Oslo, Norway
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- Fjell, Anders (author)
- Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway; Department of radiology and nuclear medicine, Oslo University Hospital, Oslo, Norway
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(creator_code:org_t)
- eLife Sciences Publications, 2021
- 2021
- English.
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In: eLIFE. - : eLife Sciences Publications. - 2050-084X. ; 10
- Related links:
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https://doi.org/10.7...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.7...
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Abstract
Subject headings
Close
- Brain age is a widely used index for quantifying individuals’ brain health as deviation from a normative brain aging trajectory. Higher-than-expected brain age is thought partially to reflect above-average rate of brain aging. Here, we explicitly tested this assumption in two indepen-dent large test datasets (UK Biobank [main] and Lifebrain [replication]; longitudinal observations ≈ 2750 and 4200) by assessing the relationship between cross-sectional and longitudinal estimates of brain age. Brain age models were estimated in two different training datasets (n ≈ 38,000 [main] and 1800 individuals [replication]) based on brain structural features. The results showed no association between cross-sectional brain age and the rate of brain change measured longitudinally. Rather, brain age in adulthood was associated with the congenital factors of birth weight and polygenic scores of brain age, assumed to reflect a constant, lifelong influence on brain structure from early life. The results call for nuanced interpretations of cross-sectional indices of the aging brain and question their validity as markers of ongoing within-person changes of the aging brain. Longitudinal imaging data should be preferred whenever the goal is to understand individual change trajectories of brain and cognition in aging.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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eLIFE
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- By the author/editor
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Vidal-Pineiro, D ...
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Wang, Yunpeng
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Krogsrud, Stine ...
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Amlien, Inge K.
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Baaré, William F ...
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Bartres-Faz, Dav ...
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show more...
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Bertram, Lars
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Brandmaier, Andr ...
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Drevon, Christia ...
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Düzel, Sandra
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Ebmeier, Klaus
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Henson, Richard ...
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Junqué, Carme
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Kievit, Rogier A ...
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Kühn, Simone
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Leonardsen, Este ...
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Lindenberger, Ul ...
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Madsen, Kathrine ...
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Magnussen, Fredr ...
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Mowinckel, Athan ...
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Nyberg, Lars, 19 ...
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Roe, James M.
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Segura, Barbara
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Smith, Stephen M ...
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Sørensen, Øystei ...
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Suri, Sana
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Westerhausen, Re ...
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Zalesky, Andrew
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Zsoldos, Enikő
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Walhovd, Kristin ...
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Fjell, Anders
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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eLIFE
- By the university
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Umeå University