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Träfflista för sökning "WFRF:(Levine D.) srt2:(2015-2019);lar1:(kth)"

Search: WFRF:(Levine D.) > (2015-2019) > Royal Institute of Technology

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1.
  • Berger, Ashton C, et al. (author)
  • A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers.
  • 2018
  • In: Cancer Cell. - : Elsevier BV. - 1535-6108 .- 1878-3686. ; 33:4, s. 690-705.e9
  • Journal article (peer-reviewed)abstract
    • We analyzed molecular data on 2,579 tumors from The Cancer Genome Atlas (TCGA) of four gynecological types plus breast. Our aims were to identify shared and unique molecular features, clinically significant subtypes, and potential therapeutic targets. We found 61 somatic copy-number alterations (SCNAs) and 46 significantly mutated genes (SMGs). Eleven SCNAs and 11 SMGs had not been identified in previous TCGA studies of the individual tumor types. We found functionally significant estrogen receptor-regulated long non-coding RNAs (lncRNAs) and gene/lncRNA interaction networks. Pathway analysis identified subtypes with high leukocyte infiltration, raising potential implications for immunotherapy. Using 16 key molecular features, we identified five prognostic subtypes and developed a decision tree that classified patients into the subtypes based on just six features that are assessable in clinical laboratories.
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2.
  • Stoudt, M. R., et al. (author)
  • The Influence of Annealing Temperature and Time on the Formation of delta-Phase in Additively-Manufactured Inconel 625
  • 2018
  • In: Metallurgical and Materials Transactions. A. - : SPRINGER. - 1073-5623 .- 1543-1940. ; 49A:7, s. 3028-3037
  • Journal article (peer-reviewed)abstract
    • This research evaluated the kinetics of delta-phase growth in laser powder bed additively-manufactured (AM) Inconel 625 during post-build stress-relief heat treatments. The temperatures ranged between 650 A degrees C and 1050 A degrees C, and the times from 0.25 to 168 hours. The presence of delta-phase was verified for each temperature/time combination through multiple techniques. A conventional time-temperature-transformation diagram was constructed from the time-temperature data. Comparison to the growth in wrought IN625 with a similar nominal composition revealed that delta-phase formation occurred at least two orders of magnitude faster in the AM IN625. The results of this study also revealed that the segregated microstructure in the as-built condition has a strong influence on the kinetics of delta-phase formation in AM IN625 as compared to a homogenized material. Since control of the delta-phase growth is essential for reliable prediction of the performance of IN625 components in service, avoiding heat treatments that promote the formation of delta-phase in AM components that are not homogenized is highly recommended. This will be particularly true at elevated temperatures where the microstructural stability and the consistency of mechanical properties are more likely to be affected by the presence of delta-phase.
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