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Physical activity and risks of breast and colorectal cancer : a Mendelian randomisation analysis

Papadimitriou, Nikos (author)
Dimou, Niki (author)
Tsilidis, Konstantinos K. (author)
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Banbury, Barbara (author)
Martin, Richard M. (author)
Lewis, Sarah J. (author)
Kazmi, Nabila (author)
Robinson, Timothy M. (author)
Albanes, Demetrius (author)
Aleksandrova, Krasimira (author)
Berndt, Sonja I. (author)
Bishop, D. Timothy (author)
Brenner, Hermann (author)
Buchanan, Daniel D. (author)
Bueno-de-Mesquita, Bas (author)
Campbell, Peter T. (author)
Castellvi-Bel, Sergi (author)
Chan, Andrew T. (author)
Chang-Claude, Jenny (author)
Ellingjord-Dale, Merete (author)
Figueiredo, Jane C. (author)
Gallinger, Steven J. (author)
Giles, Graham G. (author)
Giovannucci, Edward (author)
Gruber, Stephen B. (author)
Gsur, Andrea (author)
Hampe, Jochen (author)
Hampel, Heather (author)
Harlid, Sophia, 1978- (author)
Umeå universitet,Onkologi
Harrison, Tabitha A. (author)
Hoffmeister, Michael (author)
Hopper, John L. (author)
Hsu, Li (author)
Maria Huerta, Jose (author)
Huyghe, Jeroen R. (author)
Jenkins, Mark A. (author)
Keku, Temitope O. (author)
Kuehn, Tilman (author)
La Vecchia, Carlo (author)
Le Marchand, Loic (author)
Li, Christopher I. (author)
Li, Li (author)
Lindblom, Annika (author)
Karolinska Institutet
Lindor, Noralane M. (author)
Lynch, Brigid (author)
Markowitz, Sanford D. (author)
Masala, Giovanna (author)
May, Anne M. (author)
Milne, Roger (author)
Monninkhof, Evelyn (author)
Moreno, Lorena (author)
Moreno, Victor (author)
Newcomb, Polly A. (author)
Offit, Kenneth (author)
Perduca, Vittorio (author)
Pharoah, Paul D. P. (author)
Platz, Elizabeth A. (author)
Potter, John D. (author)
Rennert, Gad (author)
Riboli, Elio (author)
Sanchez, Maria-Jose (author)
Schmit, Stephanie L. (author)
Schoen, Robert E. (author)
Severi, Gianluca (author)
Sieri, Sabina (author)
Slattery, Martha L. (author)
Song, Mingyang (author)
Tangen, Catherine M. (author)
Thibodeau, Stephen N. (author)
Travis, Ruth C. (author)
Trichopoulou, Antonia (author)
Ulrich, Cornelia M. (author)
van Duijnhoven, Franzel J. B. (author)
van Guelpen, Bethany (author)
Umeå universitet,Onkologi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)
Vodicka, Pavel (author)
White, Emily (author)
Wolk, Alicja (author)
Karolinska Institutet,Uppsala universitet,Ortopedi
Woods, Michael O. (author)
Wu, Anna H. (author)
Peters, Ulrike (author)
Gunter, Marc J. (author)
Murphy, Neil (author)
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 (creator_code:org_t)
2020-01-30
2020
English.
In: Nature Communications. - : Springer Nature. - 2041-1723. ; 11:1
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value=0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value=0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers. Physical activity has been linked to lower risks of colorectal and breast cancer. Here, the authors present a Mendelian randomisation analysis supporting a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

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art (subject category)

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By the author/editor
Papadimitriou, N ...
Dimou, Niki
Tsilidis, Konsta ...
Banbury, Barbara
Martin, Richard ...
Lewis, Sarah J.
show more...
Kazmi, Nabila
Robinson, Timoth ...
Albanes, Demetri ...
Aleksandrova, Kr ...
Berndt, Sonja I.
Bishop, D. Timot ...
Brenner, Hermann
Buchanan, Daniel ...
Bueno-de-Mesquit ...
Campbell, Peter ...
Castellvi-Bel, S ...
Chan, Andrew T.
Chang-Claude, Je ...
Ellingjord-Dale, ...
Figueiredo, Jane ...
Gallinger, Steve ...
Giles, Graham G.
Giovannucci, Edw ...
Gruber, Stephen ...
Gsur, Andrea
Hampe, Jochen
Hampel, Heather
Harlid, Sophia, ...
Harrison, Tabith ...
Hoffmeister, Mic ...
Hopper, John L.
Hsu, Li
Maria Huerta, Jo ...
Huyghe, Jeroen R ...
Jenkins, Mark A.
Keku, Temitope O ...
Kuehn, Tilman
La Vecchia, Carl ...
Le Marchand, Loi ...
Li, Christopher ...
Li, Li
Lindblom, Annika
Lindor, Noralane ...
Lynch, Brigid
Markowitz, Sanfo ...
Masala, Giovanna
May, Anne M.
Milne, Roger
Monninkhof, Evel ...
Moreno, Lorena
Moreno, Victor
Newcomb, Polly A ...
Offit, Kenneth
Perduca, Vittori ...
Pharoah, Paul D. ...
Platz, Elizabeth ...
Potter, John D.
Rennert, Gad
Riboli, Elio
Sanchez, Maria-J ...
Schmit, Stephani ...
Schoen, Robert E ...
Severi, Gianluca
Sieri, Sabina
Slattery, Martha ...
Song, Mingyang
Tangen, Catherin ...
Thibodeau, Steph ...
Travis, Ruth C.
Trichopoulou, An ...
Ulrich, Cornelia ...
van Duijnhoven, ...
van Guelpen, Bet ...
Vodicka, Pavel
White, Emily
Wolk, Alicja
Woods, Michael O ...
Wu, Anna H.
Peters, Ulrike
Gunter, Marc J.
Murphy, Neil
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Cancer and Oncol ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Health Sciences
and Public Health Gl ...
Articles in the publication
Nature Communica ...
By the university
Umeå University
Uppsala University
Karolinska Institutet

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