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- Thomas, M, et al.
(author)
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Combining Asian-European Genome-Wide Association Studies of Colorectal Cancer Improves Risk Prediction Across Race and Ethnicity
- 2023
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In: medRxiv : the preprint server for health sciences. - : Cold Spring Harbor Laboratory.
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Journal article (other academic/artistic)abstract
- Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations. Towards addressing this deficiency, we expanded PRS development for CRC by incorporating Asian ancestry data (21,731 cases; 47,444 controls) into European ancestry training datasets (78,473 cases; 107,143 controls). The AUC estimates (95% CI) of PRS were 0.63(0.62-0.64), 0.59(0.57-0.61), 0.62(0.60-0.63), and 0.65(0.63-0.66) in independent datasets including 1,681-3,651 cases and 8,696-115,105 controls of Asian, Black/African American, Latinx/Hispanic, and non-Hispanic White, respectively. They were significantly better than the European-centric PRS in all four major US racial and ethnic groups (p-values<0.05). Further inclusion of non-European ancestry populations, especially Black/African American and Latinx/Hispanic, is needed to improve the risk prediction and enhance equity in applying PRS in clinical practice.
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- Li, Ci, et al.
(author)
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The Poses for Equine Research Dataset (PFERD)
- 2024
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In: Scientific Data. - : Springer Nature. - 2052-4463. ; 11:1
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Journal article (peer-reviewed)abstract
- Studies of quadruped animal motion help us to identify diseases, understand behavior and unravel the mechanics behind gaits in animals. The horse is likely the best-studied animal in this aspect, but data capture is challenging and time-consuming. Computer vision techniques improve animal motion extraction, but the development relies on reference datasets, which are scarce, not open-access and often provide data from only a few anatomical landmarks. Addressing this data gap, we introduce PFERD, a video and 3D marker motion dataset from horses using a full-body set-up of densely placed over 100 skin-attached markers and synchronized videos from ten camera angles. Five horses of diverse conformations provide data for various motions from basic poses (eg. walking, trotting) to advanced motions (eg. rearing, kicking). We further express the 3D motions with current techniques and a 3D parameterized model, the hSMAL model, establishing a baseline for 3D horse markerless motion capture. PFERD enables advanced biomechanical studies and provides a resource of ground truth data for the methodological development of markerless motion capture.
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- Yang, Yi, et al.
(author)
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Human-Centric Autonomous Systems With LLMs for User Command Reasoning
- 2024
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In: 2024 Ieee Winter Conference On Applications Of Computer Vision Workshops, Wacvw 2024. - : Institute of Electrical and Electronics Engineers (IEEE). - 9798350370287 - 9798350370713 ; , s. 988-994
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Conference paper (peer-reviewed)abstract
- The evolution of autonomous driving has made remarkable advancements in recent years, evolving into a tangible reality. However, a human-centric large-scale adoption hinges on meeting a variety of multifaceted requirements. To ensure that the autonomous system meets the user's intent, it is essential to accurately discern and interpret user commands, especially in complex or emergency situations. To this end, we propose to leverage the reasoning capabilities of Large Language Models (LLMs) to infer system requirements from in-cabin users' commands. Through a series of experiments that include different LLM models and prompt designs, we explore the few-shot multivariate binary classification accuracy of system requirements from natural language textual commands. We confirm the general ability of LLMs to understand and reason about prompts but underline that their effectiveness is conditioned on the quality of both the LLM model and the design of appropriate sequential prompts. Code and models are public with the link https://github.com/KTH-RPL/DriveCmd_LLM.
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