| 1. |
- Drobni, Mirva, et al.
(author)
-
A host-derived pentapeptide affecting adhesion, proliferation and local pH in Streptococcus-Actinomyces biofilm communities.
- 2006
-
In: Infection and immunity.
-
Research review (pop. science, debate, etc.)abstract
- Salivary proline-rich proteins (PRPs) attach commensal Actinomyces and Streptococcus species to teeth. Here, gel filtration, mass spectrometry and Edman degradation were applied to show the release of a pentapeptide, RGRPQ, from PRP-1 upon proteolysis by Streptococcus gordonii. Moreover, synthetic RGRPQ and derivatives were used to investigate associated innate properties and responsible motifs. The RGRPQ peptide increased 2.5-fold the growth rate of S. gordonii via a Q-dependent sequence motif, and selectively stimulated oral colonization of this organism in a rat model in vivo. By contrast, growth of Streptococcus mutans, implicated in caries, was unaffected. While the entire RGRPQ sequence was required to block sucrose-induced pH-decrease by S. gordonii and S. mutans, the N-terminal Arg residue mediated pH-increase (i.e. ammonia production) by S. gordonii alone (which exhibits Arg catabolism to ammonia). Strains of commensal viridans streptococci exhibited PRP degradation and Arg catabolism, while cariogenic species did not. The RGRPQ peptide mediated via a differential Q-dependent sequence motif, adhesion inhibition and desorption of PRP-1-binding strains of A. naeslundii genospecies 2 (5 out of 10 strains) but not of S. gordonii (n=5). The inhibitable A. naeslundii strains alone displayed the same binding profile as S. gordonii to hybrid peptides terminating in RGRPQ or GQSPQ, derived from the middle or C-terminal segments of PRP-1. The present findings indicate the presence of a host-bacteria interaction where a host peptide released by bacterial proteolysis affects key properties in biofilm formation.
|
|
| 2. |
- Larsson, Peter, 1966-, et al.
(author)
-
Mobile terminal initiated and assisted antenna selection
- 2003
-
Patent (pop. science, debate, etc.)abstract
- NOVELTY - The method involves transmitting sector messages from the base station, where each sector message is associated with a corresponding sector of the cell. The sector messages transmitted by the base station are received at a mobile terminal and a signal quality associated with each receiver sector messages is determined. At the mobile terminal one of multiple antennas is selected as a function of the signal quality determination. An antenna selection request message is transmitted from the mobile terminal to the base station. USE - For cellular network. ADVANTAGE - Improves the BS antenna selection process in cellular, broadband access network which employs multiple antennas per BS. Improves signal quality of communication links between MTs and corresponding BS which employs multiple antennas. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for an apparatus for selecting one of the multiple antennas. DESCRIPTION OF DRAWING(S) - The figure shows a technique for selecting in accordance with an embodiment of the invention.
|
|
