| 1. |
- Weinstein, John N., et al.
(författare)
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The cancer genome atlas pan-cancer analysis project
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:10, s. 1113-1120
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Forskningsöversikt (refereegranskat)abstract
- The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumor types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile. © 2013 Nature America, Inc. All rights reserved.
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| 2. |
- Ade, Peter, et al.
(författare)
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The Simons Observatory : science goals and forecasts
- 2019
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Ingår i: Journal of Cosmology and Astroparticle Physics. - : IOP Publishing. - 1475-7516. ; :2
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Tidskriftsartikel (refereegranskat)abstract
- The Simons Observatory (SO) is a new cosmic microwave background experiment being built on Cerro Toco in Chile, due to begin observations in the early 2020s. We describe the scientific goals of the experiment, motivate the design, and forecast its performance. SO will measure the temperature and polarization anisotropy of the cosmic microwave background in six frequency bands centered at: 27, 39, 93, 145, 225 and 280 GHz. The initial con figuration of SO will have three small-aperture 0.5-m telescopes and one large-aperture 6-m telescope, with a total of 60,000 cryogenic bolometers. Our key science goals are to characterize the primordial perturbations, measure the number of relativistic species and the mass of neutrinos, test for deviations from a cosmological constant, improve our understanding of galaxy evolution, and constrain the duration of reionization. The small aperture telescopes will target the largest angular scales observable from Chile, mapping approximate to 10% of the sky to a white noise level of 2 mu K-arcmin in combined 93 and 145 GHz bands, to measure the primordial tensor-to-scalar ratio, r, at a target level of sigma(r) = 0.003. The large aperture telescope will map approximate to 40% of the sky at arcminute angular resolution to an expected white noise level of 6 mu K-arcmin in combined 93 and 145 GHz bands, overlapping with the majority of the Large Synoptic Survey Telescope sky region and partially with the Dark Energy Spectroscopic Instrument. With up to an order of magnitude lower polarization noise than maps from the Planck satellite, the high-resolution sky maps will constrain cosmological parameters derived from the damping tail, gravitational lensing of the microwave background, the primordial bispectrum, and the thermal and kinematic Sunyaev-Zel'dovich effects, and will aid in delensing the large-angle polarization signal to measure the tensor-to-scalar ratio. The survey will also provide a legacy catalog of 16,000 galaxy clusters and more than 20,000 extragalactic sources.
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| 3. |
- Li, Shan Shan, et al.
(författare)
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Coupled U-Pb and Rb-Sr laser ablation geochronology trace Archean to Proterozoic crustal evolution in the Dharwar Craton, India
- 2020
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Ingår i: Precambrian Research. - : Elsevier BV. - 0301-9268. ; 343
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Tidskriftsartikel (refereegranskat)abstract
- © 2020 Elsevier B.V. The Western Dharwar Craton (WDC) and the Karwar Block (KB) in southern Peninsular India provide important windows to Earth's early crustal evolution and continental growth as these domains likely represent fragments of the first landmass or supercontinent on our planet. Here we employ, for the first time, a coupled laser ablation zircon U-Pb dating and in-situ Rb-Sr dating of micas (biotite, muscovite) and feldspars to evaluate the Meso- to Neoarchean crustal evolution and Proterozoic magmatism/metamorphism in the Karwar Block. This novel approach based on integrated geochronological results show that the WDC and KB experienced (i) a major Mesoarchean continental growth event (c. 3.2 to 2.9 Ga), (ii) younger Neoarchean and Paleoproterozoic magmatism/migmatization (syn- and post-tectonic granite formation events at c. 2.8–2.6 Ga and 2.2 Ga, respectively), and (iii) Mesoproterozoic metamorphism/thermal imprint (as young as 1.2 Ga). The zircon εHf(t) values exhibit a range from +0.4 to +9.8 in amphibolite, hornblende gneiss and trondhjemite (3.28–3.08 Ga), as well as the +6.1 to +9.7 range for 2.96 Ga old zircons in porphyritic granite, which suggests juvenile source for the magmatism that constructed this crustal block. Overall, this study illustrates the benefits of using coupled zircon U-Pb and in-situ Rb-Sr mica and feldspar dating approaches, as the former (U/Pb) provides robust constraints or a ‘baseline age’ for initial crystallization of crustal sequences whereas the latter (Rb/Sr) is sensitive to younger magmatic and metamorphic events. Thus, the integration of these two laser ablation ICP-MS based geochronometers applied to crustal evolution studies, has the potential to provide more comprehensive insights into continental growth in the early Earth, and later magmatic and metamorphic history of the region.
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| 4. |
- Topuz, G, et al.
(författare)
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Origin and significance of Early Miocene high‑potassium I-type granite plutonism in the East Anatolian plateau (the Taşlıçay intrusion)
- 2019
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Ingår i: Lithos. - : Elsevier BV. - 0024-4937. ; 348-349
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Tidskriftsartikel (refereegranskat)abstract
- © 2019 Elsevier B.V. The Early Miocene high-K I-type plutonic rocks constitute the early products of the Neogene to Quaternary magmatism, and the youngest exposed intrusions in the East Anatolian plateau. Here we deal with the petrogenesis of the Early Miocene Taşlıçay intrusion covering an area of ∼62 km2. The intrusion comprises leucogranite, and minor gabbro-monzodiorite and rhyolite porphyry. U-Pb dating of zircons from the leucogranite, monzodiorite and rhyolite porphyry yielded identical igneous crystallization ages of ∼19 Ma (Early Miocene). According to the modified alkali-lime index, the leucogranite and the rhyolite porphyry are alkali-calcic, while the gabbro-monzodiorite is transitional calcic to calc-alkalic. On variation diagrams, the gabbro-monzodiorite and the leucogranite as well as rhyolite porphyry form distinct bimodal groupings, whereby the leucogranite display well-defined linear differentiation trends, in contrast to the gabbro-monzodiorite. The leucogranite has relatively fractionated rate earth element (REE) patterns with concave-upward shapes and significant negative Eu anomalies; middle REEs are hardly fractionated with respect to heavy REEs. The gabbro-monzodiorite is characterized by high abundances of incompatible elements, slightly fractionated chondrite-normalized REE patterns with feebly negative Eu anomaly. The rhyolite porphyry is compositionally similar to the leucogranite. The geochemical features imply a fractionating mineral assemblage of hornblende, plagioclase and biotite for the leucogranite, and hornblende and ± plagioclase for the gabbro-monzodiorite. All the rock types display a narrow Sr and Nd isotopic variation (initial 87Sr/86Sr = 0.7053 to 0.7065; initial εNd = −0.5 to −3.8). The leucogranite and rhyolite porphyry exhibit gradually slightly higher initial 87Sr/86Sr and lower initial 143Nd/ 144Nd ratios relative to the gabbro-monzodiorite. Similarly, δ18O and initial εHf values of zircons suggest slightly increasing amount of crustal component from the leucogranite to the rhyolite porphyry. The gabbro-monzodiorite is probably related to partial melts from the slightly enriched lithospheric mantle. The magmas of the leucogranite and the rhyolite porphyry, on the other hand, probably resulted from the remelting of a middle- to high-K basic to intermediate rocks, compositionally similar to the gabbro-monzodiorite, and assimilated gradually slightly increasing amount of old high-silica crustal material. Several lines of evidence such as (i) presence of the well-developed dike swarm of rhyolite porphyry at the north eastern margin of the intrusion, (ii) exhumation of the intrusion at the earth's surface by Middle Miocene, (iii) widespread apatite fission tract ages between 22 and 16 Ma from literature, and (iv) the absence of the exposed intrusions younger than the Early Miocene suggest that the Early Miocene represents probably a time of continental extension and exhumation in Eastern Anatolia and NW Iran.
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