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| 2. |
- Carlsson, Sigrid, 1982, et al.
(författare)
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PSA: role in screening and monitoring patients with prostate cancer
- 2022
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Ingår i: Cancer Biomarkers: Clinical Aspects and Laboratory Determination. - 9780128243022 - 9780128243039 ; , s. 131-172
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- The test used for early detection and monitoring of prostate cancer—prostate-specific antigen (PSA)—is one of the most accurate and frequently used tumor markers in medicine today. No tumor marker has had such a critical impact on early detection through stage-migration, and monitoring after treatment for prostate cancer as the blood test PSA. This chapter provides an overview of the PSA test and its distinct molecular forms in blood, in screening, early detection and monitoring of prostate cancer. This chapter gives a summary of the randomized controlled trials of PSA-screening and recommendations from national guidelines groups. The chapter discusses the role of the PSA-test as a tool to discriminate clinically significant from indolent prostate cancer at prostate biopsy as well as the growing evidence regarding its role as a risk-stratification tool and prognostic marker of future lethal prostate cancer. © 2022 Elsevier Inc. All rights reserved.
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| 3. |
- Eriksson, Gunilla, et al.
(författare)
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Occupation of Elderhood
- 2015. - 4
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Ingår i: Occupational therapy. - Thorofare, NJ, USA : SLACK Incorporated. - 9781617110504 ; , s. 169-183
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Bokkapitel (refereegranskat)
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| 4. |
- Eriksson, Gunilla, et al.
(författare)
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Occupations of Elderhood
- 2024. - 4
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Ingår i: Occupational Therapy. - : Taylor and Francis. - 9781617110504 - 9781003522997 ; , s. 169-183
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 5. |
- Friede, Hans, 1938, et al.
(författare)
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Two-stage palatal surgery with early veloplasty and delayed hard palate repair: A balanced view on speech and midfacial growth outcome
- 2013
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Ingår i: Cleft Lip and Palate; Diagnosis and management; Third edition; (S. Berkowitz editor). - Berlin Heidelberg 2013 : Springer-Verlag. - 9783642307690 ; , s. 413-437
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Today, there is general consensus that, particularly, the protocol for repair of the palate is crucial for normal speech development and adequate long-term midfacial growth in individuals affected with cleft lip and palate (CLP). About 90 years ago, a new two-stage palatal repair method was introduced. It was characterized by early veloplasty and later closure of the hard palate. Recent follow-up studies of this regimen have revealed excellent long-term outcome regarding maxillary growth and also satisfactory speech development, even if the hard palate surgery was delayed to the stage of early mixed dentition. A speech deviation, coined as “retracted oral articulation of anterior pressure consonants,” seemed to be a relatively common speech error, temporarily affecting about one third of our preschool children born with unilateral CLP. The prevalence of other, more severe cleft speech characteristics, such as symptoms of and related to velopharyngeal incompetence and the occurrence of glottal misarticulations in particular, was very low.
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| 6. |
- Gupta, Amit, et al.
(författare)
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Detection of prostate cancer : PSA
- 2011
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Ingår i: Recent Advances in Prostate Cancer : Basic Science Discoveries and Clinical Advances - Basic Science Discoveries and Clinical Advances. - : WORLD SCIENTIFIC. - 9814329452 - 9789814329453 - 9789814329460 ; , s. 283-334
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Bokkapitel (refereegranskat)
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| 7. |
- Lilja, Hans, et al.
(författare)
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Successful separation between benign prostatic hyperplasia and prostate cancer by measurement of free and complexed PSA
- 1996
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Ingår i: Diagnosis and Treatment of Genitourinary Malignancies. - Boston, MA : Springer US. - 0927-3042. - 9781461379133 - 9781461563433 ; 88, s. 93-101
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Bokkapitel (refereegranskat)abstract
- Prostate-specific antigen (PSA) is a serine protease belonging to the human glandular kallikrein gene family [1–3]. The expression of PSA is mainly androgen dependent, and the detection of very high expression levels is restricted to the prostate tissue, but extraprostatic production at much lower levels has been demonstrated in several other tissues such as normal and malignant breast epithelium, endometrium, and bulbourethral glands [4–10]. PSA is synthesized by the columnar epithelium in the glandular ducts and acini of the prostate, but not by any other cells in prostate tissue. It is secreted at high concentrations (0.2-5mg/mL) into seminal fluid [4–6,11]. PSA is synthesized as an inactive precursor [2,3,12]. Like other glandular kallikreins, the PSA-precursor is processed stepwise by release of a leader peptide followed by liberation of an activation peptide that results in conversion of the zymogen into enzymatically active PSA [12]. This process may occur in parallel with the secretory release from the prostate epithelium and most probably occurs prior to the ejaculatory mixing of secretions from the prostate, seminal vesicles, and epididymis, since PSA is active in ejaculates collected from subjects with defective seminal vesicles and deferent ducts [1]. The protease(s) responsible for processing of the PSA precursor have not been identified. The mature 237-amino-acid form of PSA is a single-chain serine protease with extensive structural similarity to the glandular kallikreins [1,12–14]. However, the substrate specificity is uniquely different from that of the trypsin-like glandular kallikreins and resembles that of chymotrypsin, since PSA catalyzes the hydrolysis of peptide bonds’ carboxy-terminal to residues of tyrosine and leucine [15–17]. Synthetic peptide substrates for chymotrypsin can be used to measure PSA activity, but they are hydrolyzed much less efficiently by PSA than by chymotrypsin and are therefore both nonspecific and insensitive in detecting PSA activity [16].
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