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- Andersson, J., et al.
(författare)
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Echogenecity of the carotid intima-media complex is related to cardiovascular risk factors, dyslipidemia, oxidative stress and inflammation The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study
- 2009
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Ingår i: Atherosclerosis. - : Elsevier BV. - 1879-1484 .- 0021-9150. ; 204:2, s. 612-618
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Tidskriftsartikel (refereegranskat)abstract
- Background: Increased carotid artery intima-media thickness (IMT), measured by ultrasound, is related to an increased risk of cardiovascular disease. Since presence of echolucent plaques increases the risk further, we investigated if echogenecity of the carotid intima-media complex is related to markers of cardiovascular risk. Our aim was therefore to investigate if intima-media echogenecity is related to cardiovascular risk factors, or to markers of inflammation and oxidation in an exploratory investigation. Methods: The PIVUS cohort study is an observational study of 1016 (509 women and 507 men) randomly chosen individuals aged 70 living in Uppsala, Sweden. Carotid artery ultrasound measurements were performed. IMT and the grey scale median (GSM) value were calculated in the intima-media complex (IM-GSM) in the far wall of the common carotid artery. Traditional risk factors were evaluated together with indices of oxidative stress and inflammation. Results: In the multiple regression analysis, HDL-cholesterol, body mass index, conjugated diens, glutathione, e-selectin and TNF alfa were significantly related to IM-GSM. IMT was independently related to blood pressure, smoking and body mass index. Conclusion: The echolucency of the carotid intima-media was related to several cardiovascular risk factors not related to IMT, such as dyslipidemia, oxidative stress and inflammation. Since the echogenecity of the carotid intima-media complex was related to different risk factors compared to carotid IMT, it is worthwhile to further explore the usefulness of this new marker of the vascular wall. (C) 2009 Published by Elsevier Ireland Ltd.
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- Bankvall, Lars, 1980, et al.
(författare)
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BUSINESS MODELS: CHANGE OF SCOPE AND SCOPE OF CHANGE
- 2013
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Ingår i: 2013 IMP Conference in Atlanta. ; , s. 19-
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Konferensbidrag (refereegranskat)abstract
- The literature on business models has grown in recent years following new Internet-based business opportunities. Over time, the suggested conceptualisations of business models have also become more general. In this paper we aim at scrutinising the business model literature in relation to the industrial network approach in order to (1) point at problems inherent in current conceptualisations, and (2) suggest a framework that supports analysis of change or development of business models in view of network embeddedness. When problems inherent in current conceptualisations are concerned we discuss three issues; (1) their focus on the firm as the main unit of analysis, (2) the mixing of theoretical assumptions, and (3) their static nature. Moreover, most current conceptualisations set the focus on the selling firm’s perspective and thus focus on making and selling but do not include buying and using. As a result, network level aspects of business models are rare.In contrast to firm-centred approaches suggested by other authors, we suggest a focus on the ‘offering’ as the focal element of business model analysis. We identify three categories of change with regard to offerings and suggest an approach to analyse the consequences of such changes in terms of emerging business models.
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| 5. |
- Bankvall, Lars, 1980, et al.
(författare)
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BUSINESS MODELS FOR TRUCKS
- 2013
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Ingår i: NOFOMA 2013. ; , s. 16-
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Konferensbidrag (refereegranskat)abstract
- Purpose – The aim of the paper is to analyse alternative business models for trucks and the transport services that they render.Design/methodology/approach – The business model framework that we rely on is based on Mason and Spring (2011) and encompasses three related elements: market offering, technology and network architecture. The paper is mainly conceptual but draws on other, empirical, studies.Findings – We identify three types of market offerings: product based, combined and service based and discuss the principal business models that these offerings can be based on.Research limitations/implications (if applicable) – The paper contributes to the literature on business models for trucks and transport services by considering the various ways by which resources and activities can be divided among actors. The framework presented has a broader scope of application and is thus not limited to trucks and transport services.Practical implications – The paper provides possible implications for truck manufacturers, fleet owners, transport service providers and truck operators as a consequence of the alternative business models suggested.Social implications – New business models for trucks and transport services may change the conditions and incentives in ways that better tackle the environmental consequences of transport. Changing cost, risk and incentive structures, resource sharing and innovation are key aspects to consider in this regard.Originality/value – The paper opens up for new perspectives on the organising of activities and resources among the actors involved in transport.
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| 6. |
- Bankvall, Lars, 1980, et al.
(författare)
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Conceptualizing business models in industrial networks
- 2017
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Ingår i: Industrial Marketing Management. - : Elsevier BV. - 0019-8501. ; 60, s. 196-203
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Tidskriftsartikel (refereegranskat)abstract
- This paper is concerned with business model conceptualizations and outlines a framework for their analysis in industrial networks. A literature review suggests that there is a broad range of current conceptualizations of business models. Analyzing them as they pertain to interaction, business relationships, and industrial networks reveals two main explanations for their differences: first, they clearly rely on different basic theoretical assumptions, and second, they seem to address two types of business models. We refer to these as firm-centric and network-embedded business models. Based on this distinction, a scheme of analysis at the levels of the firm, relationship and network is suggested for the two types of business models. Business models are challenging from an analytical as well as managerial perspective. Further research on emerging network-embedded business models is suggested
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| 9. |
- Blomberg, Anders, 1956, et al.
(författare)
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Establishing the barnacle Balanus improvisus as a potent invertebrate monitoring system in marine ecotoxicogenomics
- 2009
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Ingår i: SETAC Europe 19th Annual Meeting Abstract Book, Göteborg 31 May - 4 June, 2009.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- There is a need for potent invertebrate systems for assessing the impacts of environmental contaminants on marine ecosystems. Balanus improvisus, a marine athropod, has a number of promising characteristics that make it a good candidate in such efforts. We have conducted sequencing of a cDNA library from the cyprid larval stage and identified several detoxification systems as well as novel B. improvisus specific genes. To investigate the toxicological gene expression response in this organism, we performed a short-term exposure experiment of the cyprid larvae to two different biofouling substances. From a natural population of B. improvisus, 300 - 1000 cyprids were treated for 23 hours with 390nM CuO or with two different concentrations (10nM or 10μM) of meditomidine. Protein expression changes were studied by 2D-PAGE analysis after DIGE labelling. For gene expression analysis by DNA miroarrays total RNA was extracted and used for cDNA and cRNA/aRNA templates. Roughly 2000 B. improvisus genes were studied represented by 3000 different probes on the arrays (each in duplicates). Candidate genes were confirmed by qPCR. A number of protein expression changes were detected on the 2D gels as a result of the different treatments. Interestingly, the response to the different treatments clearly formed distinct groups in principle component analysis. The DNA microarray analysis revealed several genes as toxicity indicators, e.g. various heat shock proteins, some proteases and factors involved in regulatory processes (transcription factors). Our data indicate that B. improvisus may serve as a tool to evaluate the impacts of marine pollution, and thus to fill the niche as an important invertebrate marine model organism for ecotoxicology and environmental genomics.
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| 10. |
- Danielsson, Lars, 1979, et al.
(författare)
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HMI principles for lateral safe applications
- 2007
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Ingår i: Universal Access in Human-Computer Interaction. Ambient Interaction. ; , s. 330-338
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Konferensbidrag (refereegranskat)
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