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Träfflista för sökning "WFRF:(Lindgren Arne) ;hsvcat:2"

Sökning: WFRF:(Lindgren Arne) > Teknik

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1.
  • Nybacka, Mikael, et al. (författare)
  • Projekt: Intelligenta inlandsvägen
  • 2009
  • Annan publikation (populärvet., debatt m.m.)abstract
    • VISION Genom samverkan med initiativtagare runt TSS-konceptet skall projektet ha bidragit till att göra E45’an till en europeisk ”Test Route”. Infrastrukturen skall erbjuda testmöjligheter av fordon i en mix av 2G, 3G, WLAN, WIMAX, NMT 450, o.s.v. Projektet skall skapa ett tydligt partnerskap mellan regionens entreprenörsdrivna mindre företag och de stora aktörerna inom två av svensk industris kärnområden (fordonsindustrin och telekomindustrin). BAKGRUND Centrum för Distansöverbryggande Teknik, ”CDT”, och Centre for Automotive system technology and Testing, CASTT, vid Luleå Tekniska Universitet, har den 1/1 2008 startat upp mål2-projektet ”den Intelligenta Inlandsvägen”. Övergripande mål är dels ett heterogent nät i form av en demomiljö med flera typer av transmissionstekniker, dels ett antal utvecklingsprojekt, med sikte på att bygga kunskap, teknik och metod som stödjer den vintertestrelaterade verksamheten inom denna demomiljö. PROJEKTSTRATEGI Ett samarbete med näringslivet både regionalt och nationellt skall säkra att framtagna prototyper tar sig ut på markanden som produkter och tjänster. Kopplingar till nationella projekt inom fordonsindustrin, inte minst Test Site Sweden, säkrar att utvecklingsinsatserna leder till ett vidgat nätverk för aktörerna inom vintertestregionen.
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2.
  • Erikson, Arne, et al. (författare)
  • Quantification of the second-order nonlinear susceptibility of collagen I using a laser scanning microscope
  • 2007
  • Ingår i: Journal of Biomedical Optics. - : SPIE-Intl Soc Optical Eng. - 1083-3668 .- 1560-2281. ; 12:4
  • Tidskriftsartikel (refereegranskat)abstract
    • Characteristic changes in the organization of fibrillar collagen can potentially serve as an early diagnostic marker in various pathological processes. Tissue types containing collagen I can be probed by pulsed high-intensity laser radiation, thereby generating second harmonic light that provides information about the composition and structure at a microscopic level. A technique was developed to determine the essential second harmonic generation (SHG) parameters in a laser scanning microscope setup. A rat-tail tendon frozen section was rotated in the xy-plane with the pulsed laser light propagating along the z-axis. By analyzing the generated second harmonic light in the forward direction with parallel and crossed polarizer relative to the polarization of the excitation laser beam, the second-order nonlinear optical susceptibilities of the collagen fiber were determined. Systematic variations in SHG response between ordered and less ordered structures were recorded and evaluated. A 500µm-thick z-cut lithiumniobate (LiNbO3) was used as reference. The method was applied on frozen sections of malignant melanoma and normal skin tissue. Significant differences were found in the values of d22, indicating that this parameter has a potential role in differentiating between normal and pathological processes. 
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3.
  • Lund, Line Naomi, et al. (författare)
  • Novel peptide ligand with high binding capacity for antibody purification
  • 2012
  • Ingår i: Journal of Chromatography A. - : Elsevier BV. - 0021-9673. ; 1225, s. 158-167
  • Tidskriftsartikel (refereegranskat)abstract
    • Small synthetic ligands for protein purification have become increasingly interesting with the growing need for cheap chromatographic materials for protein purification and especially for the purification of monoclonal antibodies (mAbs). Today, Protein A-based chromatographic resins are the most commonly used capture step in mAb down stream processing; however, the use of Protein A chromatography is less attractive due to toxic ligand leakage as well as high cost. Whether used as an alternative to the Protein A chromatographic media or as a subsequent polishing step, small synthetic peptide ligands have an advantage over biological ligands; they are cheaper to produce, ligand leakage by enzymatic degradation is either eliminated or significantly reduced, and they can in general better withstand cleaning in place (CIP) conditions such as 0.1 M NaOH. Here, we present a novel synthetic peptide ligand for purification of human IgG. Immobilized on WorkBeads, an agarose-based base matrix from Bio-Works, the ligand has a dynamic binding capacity of up to 48 mg/mL and purifies IgG from harvest cell culture fluid with purities and recovery of >93%. The binding affinity is similar to 10(5) M-1 and the interaction is favorable and entropy-driven with an enthalpy penalty. Our results show that the binding of the Fc fragment of IgG is mediated by hydrophobic interactions and that elution at low pH is most likely due to electrostatic repulsion. Furthermore, we have separated aggregated IgG from non-aggregated IgG, indicating that the ligand could be used both as a primary purification step of IgG as well as a subsequent polishing step. (C) 2012 Elsevier B.V. All rights reserved.
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4.
  • Gullman-Strand, Johan, et al. (författare)
  • Numerical and experimental study of separated flow in a plane asymmetric diffuser
  • 2004
  • Ingår i: International Journal of Heat and Fluid Flow. - : Elsevier BV. - 0142-727X .- 1879-2278. ; 25:3, s. 451-460
  • Tidskriftsartikel (refereegranskat)abstract
    • Computations of the turbulent flow through plane asymmetric diffusers for opening angles from 8degrees to 10degrees have been carried out with the explicit algebraic Reynolds stress model (EARSM) of Wallin and Johansson [J. Fluid Mech. 403 (2000) 89]. It is based on a two-equation platform in the form of a low-Re K - omega formulation, see e.g. Wilcox [Turbulence Modeling for CFD, DCW Industries Inc., 1993]. The flow has also been studied experimentally for the 8.5degrees opening angle using PIV and LDV. The models under-predict the size and magnitude of the recirculation zone. This is, at least partially, attributed to an over-estimation of the wall normal turbulence component in a region close to the diffuser inlet and to the use of damping functions in the near-wall region. By analyzing the balance between the production and dissipation of the turbulence kinetic energy we find that the predicted dissipation is too large. Hence, we can identify a need for improvement of the modeling the transport equation for the turbulence length-scale related quantity.
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5.
  • Johansson, Arne V., et al. (författare)
  • Experimental tests of mean velocity distribution laws derived by lie group symmetry methods in turbulent boundary layers
  • 2004
  • Ingår i: IUTAM SYMPOSIUM ON REYNOLDS NUMBER SCALING IN TURBULENT FLOW. - 1402017758 ; , s. 257-264
  • Konferensbidrag (refereegranskat)abstract
    • New scaling laws for turbulent boundary layers recently derived (see Oberlack, 2001) using Lie group symmetry methods have been tested against experimental data from the KTH data-base for zero-pressure-gradient turbulent boundary layers. The most significant new law gives an exponential variation of the mean velocity defect in the outer (wake) region. It was shown to fit very well the experimental data over a large part of the boundary layer, from the outer part of the overlap region to about half the boundary layer thickness (delta(99)). A small modification of the innermost part of the log-layer is predicted by the same method, in the form of an additive constant within the log-function, and was confirmed by the experimental data.
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6.
  • Lindgren, Björn, et al. (författare)
  • Evaluation of a new wind tunnel with expanding corners
  • 2004
  • Ingår i: Experiments in Fluids. - : Springer Science and Business Media LLC. - 0723-4864 .- 1432-1114. ; 36:1, s. 197-203
  • Tidskriftsartikel (refereegranskat)abstract
    • A new low-speed, closed-circuit, closed-test-section wind tunnel, called BLT, has been designed and built at KTH. The turbulence intensity in the test section is <0.04%, the total pressure variation is <+/-0.1% and the temperature variation is <+/-0.07degreesC over the cross-sectional area. The concept of expanding corners with an expansion ratio of 1.32 first investigated by Lindgren et al. in 1998, has been implemented successfully with a two-dimensional total pressure loss coefficient of 0.047 at a chord Reynolds number of 200,000. It is comparable to or even better than the values found in most wind tunnels using nonexpanding corners. The findings in this study prove the usefulness of expanding corners to achieve a compact wind tunnel circuit design without compromising the flow quality.
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7.
  • Lindgren, Björn, et al. (författare)
  • Evaluation of scaling laws derived from Lie group symmetry methods in zero-pressure-gradient turbulent boundary layers
  • 2004
  • Ingår i: Journal of Fluid Mechanics. - 0022-1120 .- 1469-7645. ; 502, s. 127-152
  • Tidskriftsartikel (refereegranskat)abstract
    • New scaling laws for turbulent boundary layers recently derived (see Oberlack 2000) using Lie group symmetry methods have been tested against experimental data from the KTH database for zero-pressure-gradient turbulent boundary layers. The most significant new law predicts an exponential variation of the mean velocity defect in the outer (wake) region. It was shown to fit the experimental data very well over a large part of the boundary layer, from the outer part of the overlap region to about half the boundary layer thickness (699). In the outermost part of the boundary layer the velocity defect falls more rapidly than predicted by the exponential law. This can partly be attributed to intermittency in that region but the main cause stems from non-parallel effects that are not accounted for in the derivation of the exponential law. The two-point correlation function behaviour in the outer region, where an exponential velocity defect law is observed, was found to be very different from that derived under the assumption of parallel flow. It is found to be plausible that this indeed can be attributed to non-parallel effects. A small modification of the innermost part of the log-layer in the form of an additive constant within the log-function is predicted by the Lie group symmetry method. A qualitative agreement with such a behaviour just below the overlap region was found. The derived scaling law behaviour in the overlap region for the two-point correlation functions was also verified by the experimental data.
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8.
  • Lindgren, Björn, et al. (författare)
  • Measurement and calculation of guide vane performance in expanding bends for wind-tunnels
  • 1998
  • Ingår i: Experiments in Fluids. - : Springer. - 0723-4864 .- 1432-1114. ; 24, s. 265-272
  • Tidskriftsartikel (refereegranskat)abstract
    • The design of guide vanes for use in expanding bends was investigated both experimentally and numerically. The primary application in mind is the use of expanding corners in wind-tunnels for the purpose of constructing compact circuits with low losses. To investigate the performance of guide vanes in realistic situations expansion ratios between 1 and 3 were tested in the experiments. These were carried out in an open wind-tunnel specially built for the present purpose. The experimental results demonstrated that suitably designed guide vanes give very low losses and retained flow quality even for quite substantial expansion ratios. For wind-tunnel applications expansion ratios around 1.3 seem appropriate, Optimization of a guide vane design was done using a two-dimensional cascade code, Mises. A new vane optimized for an expansion ratio of 4/3 gave a two-dimensional total pressure-loss coefficient as low as 0.041 for a chord Reynolds number of 200,000.
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9.
  • Schirmer, M. D., et al. (författare)
  • White matter hyperintensity quantification in large-scale clinical acute ischemic stroke cohorts - The MRI-GENIE study
  • 2019
  • Ingår i: Neuroimage-Clinical. - : Elsevier BV. - 2213-1582. ; 23
  • Tidskriftsartikel (refereegranskat)abstract
    • White matter hyperintensity (WMH) burden is a critically important cerebrovascular phenotype linked to prediction of diagnosis and prognosis of diseases, such as acute ischemic stroke (AIS). However, current approaches to its quantification on clinical MRI often rely on time intensive manual delineation of the disease on T2 fluid attenuated inverse recovery (FLAIR), which hinders high-throughput analyses such as genetic discovery. In this work, we present a fully automated pipeline for quantification of WMH in clinical large-scale studies of AIS. The pipeline incorporates automated brain extraction, intensity normalization and WMH segmentation using spatial priors. We first propose a brain extraction algorithm based on a fully convolutional deep learning architecture, specifically designed for clinical FLAIR images. We demonstrate that our method for brain extraction outperforms two commonly used and publicly available methods on clinical quality images in a set of 144 subject scans across 12 acquisition centers, based on dice coefficient (median 0.95; inter-quartile range 0.94-0.95; p < 0.01) and Pearson correlation of total brain volume (r = 0.90). Subsequently, we apply it to the large-scale clinical multi-site MRI-GENIE study (N = 2783) and identify a decrease in total brain volume of -2.4 cc/year. Additionally, we show that the resulting total brain volumes can successfully be used for quality control of image preprocessing. Finally, we obtain WMH volumes by building on an existing automatic WMH segmentation algorithm that delineates and distinguishes between different cerebrovascular pathologies. The learning method mimics expert knowledge of the spatial distribution of the WMH burden using a convolutional auto-encoder. This enables successful computation of WMH volumes of 2533 clinical AIS patients. We utilize these results to demonstrate the increase of WMH burden with age (0.950 cc/year) and show that single site estimates can be biased by the number of subjects recruited.
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10.
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