| 1. |
- Boutry, Céline, et al.
(författare)
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The Adjuvanted Recombinant Zoster Vaccine Confers Long-Term Protection Against Herpes Zoster : Interim Results of an Extension Study of the Pivotal Phase 3 Clinical Trials ZOE-50 and ZOE-70
- 2022
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Ingår i: Clinical Infectious Diseases. - : Oxford University Press. - 1058-4838 .- 1537-6591. ; 74:8, s. 1459-1467
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Tidskriftsartikel (refereegranskat)abstract
- Efficacy against herpes zoster and immune responses to the adjuvanted recombinant zoster vaccine plateaued at high levels between 5.1 and 7.1 years (mean) post-vaccination, suggesting that its clinical benefit in older adults is sustained for at least 7 years post-vaccination. Background This ongoing follow-up study evaluated the persistence of efficacy and immune responses for 6 additional years in adults vaccinated with the glycoprotein E (gE)-based adjuvanted recombinant zoster vaccine (RZV) at age >= 50 years in 2 pivotal efficacy trials (ZOE-50 and ZOE-70). The present interim analysis was performed after >= 2 additional years of follow-up (between 5.1 and 7.1 years [mean] post-vaccination) and includes partial data for year (Y) 8 post-vaccination. Methods Annual assessments were performed for efficacy against herpes zoster (HZ) from Y6 post-vaccination and for anti-gE antibody concentrations and gE-specific CD4[2+] T-cell (expressing >= 2 of 4 assessed activation markers) frequencies from Y5 post-vaccination. Results Of 7413 participants enrolled for the long-term efficacy assessment, 7277 (mean age at vaccination, 67.2 years), 813, and 108 were included in the cohorts evaluating efficacy, humoral immune responses, and cell-mediated immune responses, respectively. Efficacy of RZV against HZ through this interim analysis was 84.0% (95% confidence interval [CI], 75.9-89.8) from the start of this follow-up study and 90.9% (95% CI, 88.2-93.2) from vaccination in ZOE-50/70. Annual vaccine efficacy estimates were >84% for each year since vaccination and remained stable through this interim analysis. Anti-gE antibody geometric mean concentrations and median frequencies of gE-specific CD4[2+] T cells reached a plateau at approximately 6-fold above pre-vaccination levels. Conclusions Efficacy against HZ and immune responses to RZV remained high, suggesting that the clinical benefit of RZV in older adults is sustained for at least 7 years post-vaccination.
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| 2. |
- Li, Jung Shian, et al.
(författare)
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Scheduling performance enhancement by network coding in wireless mesh networks
- 2012
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Ingår i: IET Communications. - : Institution of Engineering and Technology. - 1751-8628 .- 1751-8636. ; 6:13, s. 1912-1919
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Tidskriftsartikel (refereegranskat)abstract
- When a wireless mesh network accommodates interactive applications with quality of service requirements, schedule-based protocols are more suitable than contention-based protocols. In this paper, the problem of determining an appropriate schedule assignment for multiple group transmissions within a spatial time division multiple access link scheduling network is referred to as an integrated multiple-group communication and link scheduling problem. A polynomial-time scheduling algorithm, designated as a source-parallel-aware assignment (SPAA), is proposed to increase the spatial utilisation within each time slot in order to enhance the network throughput. Furthermore, an advanced version of SPAA, designated as joint source-parallel-aware assignment with network coding (JSANC), is proposed to reduce the effects of bottleneck paths on the schedule frame length by flexibly applying conventional or opportunistic network coding approaches. Simulation results show that the proposed algorithms achieve a better network throughput than existing flow-based or particular order-based scheduling schemes.
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| 3. |
- Liu, F., et al.
(författare)
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Analysis of network trust dynamics based on the evolutionary game
- 2015
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Ingår i: SCIENTIA IRANICA. - : Elsevier. - 1026-3098. ; 22:6, s. 2548-2557
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Tidskriftsartikel (refereegranskat)abstract
- Trust, as a multi-disciplinary research domain, is of high importance in the area of network security and it has increasingly become an important mechanism to solve the issues of distributed network security. Trust is also an effective mechanism to simplify complex society, and is the source to promote personal or social cooperation. From the perspective of network ecological evolution, we propose the model of the P2P Social Ecological Network. Based on game theory, we also put forward network trust dynamics and network eco-evolution by analysis of network trust and the development of the dynamics model. In this article, we further analyze the dynamic equation, and the evolutionary trend of the trust relationship between nodes using the replicator dynamics principle. Finally, we reveal the law of trust evolution dynamics, and the simulation results clearly describe that the dynamics of trust can be effective in promoting the stability and evolution of networks. (C) 2015 Sharif University of Technology. All rights reserved.
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| 4. |
- Pan, Nan, et al.
(författare)
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Nonlinear tool traces fast tracing algorithm based on single point laser detection
- 2019
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Ingår i: Journal of Intelligent & Fuzzy Systems. - : IOS Press. - 1064-1246 .- 1875-8967. ; 36:2, s. 1109-1120
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Tidskriftsartikel (refereegranskat)abstract
- There are lots of line traces on the surface of the broken ends which left in the cable cutting case crime scene along the high-speed railway in China. The line traces usually present nonlinear morphological features and has strong randomness. It is not very effective when using existing image-processing and three-dimensional scanning methods to do the trace comparison, therefore, a fast algorithm based on wavelet domain feature aiming at the nonlinear line traces is put forward to make fast trace analysis and infer the criminal tools. The proposed algorithm first applies wavelet decomposition to the 1-D signals which picked up by single point laser displacement sensor to partially reduce noises. After that, the dynamic time warping is employed to do trace feature similarity matching. Finally, using linear regression machine learning algorithm based on gradient descent method to do constant iteration. The experiment results of cutting line traces sample data comparison demonstrate the accuracy and reliability of the proposed algorithm. © 2019 - IOS Press and the authors. All rights reserved
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