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Report on computati...
Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group
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- Amgad, M (author)
- Emory University,Emory Univ, GA USA,UCL Canc Inst, England; Icahn Sch Med Mt Sinai, NY 10029 USA
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- Stovgaard, ES (author)
- Univ Copenhagen, Denmark
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- Balslev, E (author)
- Univ Copenhagen, Denmark
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- Thagaard, J (author)
- Tech Univ Denmark, Denmark; Visiopharm AS, Denmark
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- Chen, W (author)
- FDA CDRH OSEL, MD USA
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- Dudgeon, S (author)
- FDA CDRH OSEL, MD USA
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- Sharma, A (author)
- Emory Univ, GA USA
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- Kerner, JK (author)
- PathAI, MA USA,Massachusetts Gen Hosp, MA 02114 USA
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- Denkert, C (author)
- Northwestern University Feinberg School of Medicine,Philipps Univ Marburg, Germany; Philipps Univ Marburg, Germany; German Canc Consortium DKTK, Germany,Northwestern Univ, IL 60611 USA
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- Yuan, Y (author)
- Inst Canc Res, England
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- AbdulJabbar, K (author)
- Inst Canc Res, England
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- Wienert, S (author)
- Philipps Univ Marburg, Germany,Univ Texas MD Anderson Canc Ctr, TX 77030 USA
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- Savas, P (author)
- Univ Melbourne, Australia
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- Voorwerk, L (author)
- Netherlands Canc Inst, Netherlands
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- Beck, AH (author)
- PathAI, MA USA
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- Madabhushi, A (author)
- Case Western Reserve Univ, OH 44106 USA; Louis Stokes Cleveland Vet Adm Med Ctr, OH USA
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- Hartman, J (author)
- Karolinska Institutet,Karolinska Inst, Sweden; Univ Hosp, Sweden
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- Sebastian, MM (author)
- Univ Texas MD Anderson Canc Ctr, TX 77030 USA,Ontario Inst Canc Res, Canada; Western Gen Hosp, Scotland
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- Horlings, HM (author)
- Netherlands Canc Inst, Netherlands
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- Hudecek, J (author)
- Netherlands Canc Inst, Netherlands
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- Ciompi, F (author)
- Radboud Univ Nijmegen, Netherlands
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Moore, DA (author)
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- Singh, R (author)
- Icahn Sch Med Mt Sinai, NY 10029 USA,NRG Oncol NSABP, PA USA
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- Roblin, E (author)
- Univ Paris Sud, France
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- Balancin, ML (author)
- Univ Sao Paulo, Brazil
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- Mathieu, MC (author)
- Gustave Roussy Canc Campus, France
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Lennerz, JK (author)
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- Kirtani, P (author)
- Manipal Hosp Dwarka, India
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- Chen, IC (author)
- Natl Taiwan Univ, Taiwan
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- Braybrooke, JP (author)
- Univ Oxford, England; Univ Hosp Bristol NHS Fdn Trust, England
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- Pruneri, G (author)
- Ist Nazl Tumori, Italy; Univ Milan, Italy
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- Demaria, S (author)
- Weill Cornell Med Coll, NY USA
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- Adams, S (author)
- NYU Langone Med Ctr, NY USA
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- Schnitt, SJ (author)
- Brigham & Womens Hosp, MA 02115 USA,SUNY Stony Brook, NY 11794 USA
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- Lakhani, SR (author)
- Univ Queensland, Australia,Univ Melbourne, Australia; GZA ZNA Ziekenhuizen, Belgium
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- Rojo, F (author)
- CIBERONC Inst Invest Sanitaria Fdn Jimenez Diaz I, Spain; GEICAM Spanish Breast Canc Res Grp, Spain
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- Comerma, L (author)
- CIBERONC Inst Invest Sanitaria Fdn Jimenez Diaz I, Spain; GEICAM Spanish Breast Canc Res Grp, Spain
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- Badve, SS (author)
- Indiana Univ Sch Med, IN 46202 USA
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- Khojasteh, M (author)
- Roche Tissue Diagnost, CA USA
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Symmans, WF (author)
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- Sotiriou, C (author)
- Univ Libre Bruxelles ULB, Belgium; Univ Libre Bruxelles, Belgium
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- Gonzalez-Ericsson, P (author)
- Vanderbilt Univ, TN USA
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- Pogue-Geile, KL (author)
- NRG Oncol NSABP, PA USA
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Kim, RS (author)
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- Rimm, DL (author)
- Yale Univ, CT 06510 USA
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- Viale, G (author)
- European Inst Oncol IRCCS, Italy; State Univ Milan, Italy
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- Hewitt, SM (author)
- NCI, MD 20892 USA,Univ Paris Saclay, France; Univ Paris Sud, France
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Bartlett, JMS (author)
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- Penault-Llorca, F (author)
- Ctr Jean Perrin, France; Univ Clermont Auvergne, France
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- Goel, S (author)
- Peter MacCallum Canc Ctr, Australia
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- Lien, HC (author)
- Natl Taiwan Univ Hosp, Taiwan
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- Loibl, S (author)
- GBG Forsch GmbH, Germany
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- Kos, Z (author)
- BC Canc, Canada
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- Loi, S (author)
- Univ Melbourne, Australia; Peter MacCallum Canc Ctr, Australia
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- Hanna, MG (author)
- Mem Sloan Kettering Canc Ctr, NY 10021 USA
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Michiels, S (author)
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- Kok, M (author)
- Netherlands Canc Inst, Netherlands; Netherlands Canc Inst, Netherlands
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- Nielsen, TO (author)
- Univ British Columbia, Canada
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- Lazar, AJ (author)
- Univ Texas MD Anderson Canc Ctr, TX 77030 USA; Univ Texas MD Anderson Canc Ctr, TX 77030 USA; Univ Texas MD Anderson Canc Ctr, TX 77030 USA; Univ Texas MD Anderson Canc Ctr, TX 77030 USA
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- Bago-Horvath, Z (author)
- Med Univ Vienna, Austria
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- Kooreman, LFS (author)
- Maastricht Univ, Netherlands; Maastricht Univ, Netherlands
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- van der Laak, Jeroen (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Klinisk patologi,Radboud Univ Nijmegen, Netherlands
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Saltz, J (author)
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- Gallas, BD (author)
- FDA CDRH OSEL, MD USA
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- Kurkure, U (author)
- Roche Tissue Diagnost, CA USA
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- Barnes, M (author)
- Roche Diagnost Informat Solut, CA USA
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Salgado, R (author)
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Cooper, LAD (author)
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- Ehinger, Anna (creator_code:cre_t)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Pathology, Lund,Section V,Department of Clinical Sciences, Lund
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(creator_code:org_t)
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- 2020-05-12
- 2020
- English.
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In: NPJ breast cancer. - : Springer Science and Business Media LLC. - 2374-4677. ; 6:1, s. 16-
- Related links:
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https://www.nature.c...
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show more...
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http://dx.doi.org/10... (free)
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https://liu.diva-por... (primary) (Raw object)
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http://kipublication...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Assessment of tumor-infiltrating lymphocytes (TILs) is increasingly recognized as an integral part of the prognostic workflow in triple-negative (TNBC) and HER2-positive breast cancer, as well as many other solid tumors. This recognition has come about thanks to standardized visual reporting guidelines, which helped to reduce inter-reader variability. Now, there are ripe opportunities to employ computational methods that extract spatio-morphologic predictive features, enabling computer-aided diagnostics. We detail the benefits of computational TILs assessment, the readiness of TILs scoring for computational assessment, and outline considerations for overcoming key barriers to clinical translation in this arena. Specifically, we discuss: 1. ensuring computational workflows closely capture visual guidelines and standards; 2. challenges and thoughts standards for assessment of algorithms including training, preanalytical, analytical, and clinical validation; 3. perspectives on how to realize the potential of machine learning models and to overcome the perceptual and practical limits of visual scoring.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk bildbehandling (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Image Processing (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Amgad, M
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Stovgaard, ES
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Balslev, E
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Thagaard, J
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Chen, W
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Dudgeon, S
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show more...
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Sharma, A
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Kerner, JK
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Denkert, C
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Yuan, Y
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AbdulJabbar, K
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Wienert, S
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Savas, P
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Voorwerk, L
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Beck, AH
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Madabhushi, A
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Hartman, J
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Sebastian, MM
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Horlings, HM
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Hudecek, J
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Ciompi, F
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Moore, DA
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Singh, R
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Roblin, E
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Balancin, ML
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Mathieu, MC
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Lennerz, JK
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Kirtani, P
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Chen, IC
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Braybrooke, JP
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Pruneri, G
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Demaria, S
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Adams, S
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Schnitt, SJ
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Lakhani, SR
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Rojo, F
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Comerma, L
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Badve, SS
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Khojasteh, M
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Symmans, WF
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Sotiriou, C
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Gonzalez-Ericsso ...
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Pogue-Geile, KL
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Kim, RS
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Rimm, DL
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Viale, G
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Hewitt, SM
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Bartlett, JMS
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Penault-Llorca, ...
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Goel, S
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Lien, HC
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Loibl, S
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Kos, Z
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Loi, S
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Hanna, MG
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Michiels, S
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Kok, M
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Nielsen, TO
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Lazar, AJ
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Bago-Horvath, Z
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Kooreman, LFS
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van der Laak, Je ...
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Saltz, J
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Gallas, BD
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Kurkure, U
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Barnes, M
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Salgado, R
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Cooper, LAD
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Ehinger, Anna
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Medical Engineer ...
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and Medical Image Pr ...
- Articles in the publication
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NPJ breast cance ...
- By the university
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Karolinska Institutet
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Lund University
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Linköping University