↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Träfflista för sökning "WFRF:(Luedeke M) srt2:(2021);mspu:(article)"

Search: WFRF:(Luedeke M) > (2021) > Journal article

Result 1-2 of 2

Sort/group result

Sort by: Hits per page:

Enumeration	Reference	Cover	Find
1.	Conti, DV, et al. (author) Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction 2021 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 53:3, s. 413-413 Journal article (other academic/artistic)
2.	Conti, David, V, et al. (author) Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction 2021 In: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 53:1, s. 65-75 Journal article (peer-reviewed)abstract Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction. A meta-analysis of genome-wide association studies across different populations highlights new risk loci and provides a genetic risk score that can stratify prostate cancer risk across ancestries.

Skapa referenser, mejla, bekava och länka

Permalink

Result 1-2 of 2

Refine your search

Type of publication: journal article (2)Undo refine

Type of content: other academic/artistic (1); peer-reviewed (1)

Author/Editor: Jenster, G (1); Castano-Vinyals, G (1); Kim, J. (1); Varma, R. (1); Hakansson, N. (1); Auvinen, A (1); show more...; Zheng, W. (1); Brenner, H (1); Khaw, Kay-Tee (1); Riboli, Elio (1); Riboli, E. (1); SCHAID, DJ (1); Eklund, M (1); Giles, GG (1); Torres, M. (1); Wolk, A (1); Wolk, Alicja (1); Donovan, Jenny L (1); Hamdy, Freddie C (1); Neal, David E (1); Eeles, Rosalind A (1); Haiman, Christopher ... (1); Kote-Jarai, Zsofia (1); Schumacher, Fredrick ... (1); Benlloch, Sara (1); Muir, Kenneth (1); Berndt, Sonja I (1); Conti, David V (1); Wiklund, Fredrik (1); Chanock, Stephen J (1); Gapstur, Susan M (1); Stevens, Victoria L (1); Tangen, Catherine M (1); Batra, Jyotsna (1); Clements, Judith A (1); Pashayan, Nora (1); Schleutker, Johanna (1); Albanes, Demetrius (1); West, Catharine M L (1); Mucci, Lorelei A (1); Cancel-Tassin, Geral ... (1); Koutros, Stella (1); Maehle, Lovise (1); Travis, Ruth C (1); Rosenstein, Barry S (1); Lu, Yong-Jie (1); Giles, Graham G (1); Kibel, Adam S (1); Vega, Ana (1); Kogevinas, Manolis (1); show less...

University: Karolinska Institutet (2); Uppsala University (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

Year: 2021 (2)Undo refine

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - National Library Systems
LIBRIS.kb.se

pil uppåt

Close

Copy and save the link in order to return to this view