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1.	Kehoe, Laura, et al. (author) Make EU trade with Brazil sustainable 2019 In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341- Journal article (other academic/artistic)
2.	Mikus, Maria, et al. (author) Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux 2019 In: The European respiratory journal. - : European Respiratory Society (ERS). - 1399-3003 .- 0903-1936. ; 53:6 Journal article (other academic/artistic)
3.	Schofield, JPR, et al. (author) Stratification of asthma phenotypes by airway proteomic signatures 2019 In: The Journal of allergy and clinical immunology. - : Elsevier BV. - 1097-6825 .- 0091-6749. ; 144:1, s. 70-82 Journal article (peer-reviewed)
4.	Wiedmann, Thomas, et al. (author) Development of a methodology for the assessment of global environmental impacts of traded goods and services : Draft Final Report 2009 Reports (other academic/artistic)
5.	Zhang, Qian, et al. (author) The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling 2021 In: Cell Metabolism. - : Elsevier BV. - 1550-4131 .- 1932-7420. ; 33:4, s. 833-844 Journal article (peer-reviewed)abstract Uncertainty exists as to whether the glucose-dependent insulinotropic polypeptide receptor (GIPR) should be activated or inhibited for the treatment of obesity. Gipr was recently demonstrated in hypothalamic feeding centers, but the physiological relevance of CNS Gipr remains unknown. Here we show that HFD-fed CNS-Gipr KO mice and humanized (h)GIPR knockin mice with CNS-hGIPR deletion show decreased body weight and improved glucose metabolism. In DIO mice, acute central and peripheral administration of acyl-GIP increases cFos neuronal activity in hypothalamic feeding centers, and this coincides with decreased body weight and food intake and improved glucose handling. Chronic central and peripheral administration of acyl-GIP lowers body weight and food intake in wild-type mice, but shows blunted/absent efficacy in CNS-Gipr KO mice. Also, the superior metabolic effect of GLP-1/GIP co-agonism relative to GLP-1 is extinguished in CNS-Gipr KO mice. Our data hence establish a key role of CNS Gipr for control of energy metabolism.

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Type of publication: journal article (4); reports (1)

Type of content: other academic/artistic (3); peer-reviewed (2)

Author/Editor: Evans, H. (2); Hu, X. (2); Williams, S. (2); Ahmed, H. (2); Martin, J. (2); Yu, W. (2); show more...; Auffray, C (2); De Meulder, B (2); Versnel, J. (2); Yang, X. (2); Chaleckis, R (2); Wheelock, CE (2); Sehgal, N. (2); Brinkman, P (2); Howarth, P (2); Dahlen, SE (2); Djukanovic, R (2); Sterk, PJ (2); Chung, KF (2); Montuschi, P (2); Murray, CS (2); Bush, A (2); Fowler, SJ (2); Sandström, Thomas, 1 ... (2); Thorsen, J (2); Stokholm, J (2); Nordlund, B (2); Shaw, DE (2); Sousa, AR (2); Bonnelykke, K (2); Bates, S (2); Nilsson, Peter (2); Nicholas, B. (2); Walker, S (2); Smith, J. (2); Allen, D (2); Konradsen, JR (2); Edwards, J (2); Smith, C (2); Ballereau, S (2); Lambrecht, B (2); Lemonnier, N (2); Hu, R (2); Ward, J (2); Scott, S (2); Russell, K. (2); Ostling, J (2); Gomez, C (2); Ericsson, M (2); Thorngren, JO (2); show less...

University: Royal Institute of Technology (3); Umeå University (2); Uppsala University (2); Karolinska Institutet (2); Stockholm University (1); Lund University (1); show more...; Swedish Environmental Protection Agency (1); Mid Sweden University (1); Chalmers University of Technology (1); Swedish University of Agricultural Sciences (1); show less...

Language: English (5)

Research subject (UKÄ/SCB): Medical and Health Sciences (3); Natural sciences (2); Engineering and Technology (1); Social Sciences (1)

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