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Sökning: WFRF:(Mårtensson Thomas) > Uppsala universitet

  • Resultat 1-10 av 27
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1.
  • Mårtensson, Thomas, et al. (författare)
  • Choice of Endoscopic Procedure in Children With Clinically Suspected Gastrointestinal Graft-Versus-Host Disease.
  • 2018
  • Ingår i: Journal of Pediatric Gastroenterology and Nutrition - JPGN. - 0277-2116 .- 1536-4801. ; 66:5, s. 744-750
  • Tidskriftsartikel (refereegranskat)abstract
    • Objectives: Gastrointestinal graft-versus-host disease (GI-GVHD) is a potentially life-threatening complication after hematopoietic stem cell transplantation. Symptoms indicating GI-GVHD motivates endoscopy with biopsy sampling and histopathological confirmation. Optimal extent of endoscopy in children is, however, presently unknown. Therefore, we aimed to evaluate whether biopsies from the rectosigmoid area versus the rest of the colon/ileocolon with or without biopsies from simultaneous upper endoscopy, were equally reliable for detection of GI-GVHD and relevant differential diagnoses.Methods: Retrospective multicenter study based on histopathological re-evaluation of biopsies and hospital record data, collected from children with suspected GI-GVHD.Results: Forty-four children with 51 endoscopic occasions (81 procedures) were included. Thirty-nine of 51 (76.5%) were diagnosed as GI-GVHD, 14 (27.4%) received a differential diagnosis and 7 (13.7%) had normal histology findings. Comorbidity, that is, simultaneous detection of a differential diagnosis and GI-GVHD, was observed in 9 (23.1%) cases. Cytomegalovirus infection was the most frequent differential diagnosis, 6 of 7 were detected in biopsies from rectosigmoid and esophagogastroduodenal areas. Sensitivity for detection of GI-GVHD in biopsies collected from rectosigmoid-ileocolonic-, rectosigmoid-, or esophagogastroduodenal areas were 97.4%, 84.6%, 83.3%, respectively, and 97.4% when the latter 2 were merged. The difference, nondetected GI-GVHD in the rectosigmoid area versus detected elsewhere in the GI tract, was statistically significant (P = 0.03).Conclusions: Biopsies collected from the rectosigmoid area solely were not optimal for detection of pediatric GI-GVHD. When biopsy sampling from rectosigmoid and upper GI tract areas was combined, the sensitivity for GI-GVHD was, however, equally high as for ileocolonoscopy or full upper and lower endoscopy.
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2.
  • Mårtensson, Thomas, et al. (författare)
  • Diagnostic disagreement between clinical standard histopathological- and retrospective assessment of histopathology-based gastrointestinal graft-versus-host disease in children
  • 2020
  • Ingår i: Pediatric Transplantation. - : WILEY. - 1397-3142 .- 1399-3046. ; 24:8
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: No previous paediatric study has evaluated the frequency of diagnostic disagreement between clinical standard histopathological assessment (CSHA) and retrospective, independent, histopathological assessment (RIHA) of gastrointestinal Graft-Versus-Host Disease (GI-GVHD).Methods: In a retrospective cohort study, based on gastrointestinal biopsies collected from allogeneic HSCT-treated children (<18 years) with symptom-based GI-GVHD, we evaluated; disagreement of histopathology-based GI-GVHD diagnosis in CSHA vs RIHA, and potential clinical consequences of differences between the assessments. The CSHA-based diagnoses were retrieved from histopathology reports. The RIHA was performed by one pathologist, blinded to the CSHA outcomes and based on the minimal criteria for histopathology-based GI-GVHD diagnosis by theNIH 2014.Results: Seventy children with 92 endoscopic occasions (including 22 re-endoscopies) were enrolled. GI-GVHD was observed in 73% (67/92) of the endoscopies in the RIHA and in 54% (50/92) in the CSHA (P = .014). The RIHA confirmed 94% (47/50) with GI-GVHD and 52% (22/42) with non-GI-GVHD diagnoses, established in the CSHA. Disagreement, that is endoscopic occasions with GI-GVHD solely detected in RIHA or detection of GI-GVHD in CSHA but not in RIHA, was observed in 20/42 (48%) and 3/50 (6%), respectively (McNemar's test, P = .0008). The risk of a subsequent re-endoscopy was higher in endoscopic occasions with GI-GVHD detected in RIHA but not in CSHA vs if non-GI-GVHD were detected in both readings (P = .005).Conclusion: Our results suggest that in children with symptom-based GI-GVHD without histopathological confirmation in CSHA, a second,NIH 2014based histopathological assessment should be considered before performing a re-endoscopy.
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3.
  • Bakardjieva Engelbrekt, Antonina, et al. (författare)
  • EU kan fastna i negativ spiral
  • 2012
  • Ingår i: Svenska Dagbladet, Brännpunkt. - 1101-2412.
  • Tidskriftsartikel (populärvet., debatt m.m.)
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4.
  • Bakardjieva Engelbrekt, Antonina, et al. (författare)
  • The EU and Global Imbalances
  • 2015
  • Ingår i: The EU’s Role in Fighting Global Imbalances. - Cheltenham : Edward Elgar Publishing. - 9781784716721 - 9781784716738 - 978 1 78471 672 1 ; , s. 1-15
  • Bokkapitel (refereegranskat)
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8.
  • Bridging the Prosperity Gap in the EU : The Social Challenge Ahead
  • 2018
  • Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
    • Bridging the Prosperity Gap in the EU addresses the great social challenge currently facing the European Union. Taking an interdisciplinary approach, the authors invaluably pinpoint both overarching problems and possibilities associated with the social dimension of European integration. Prominent researchers of economics, law and political science tackle this complex issue, providing new solutions within their respective fields of expertise. The chapters cover crucial policy challenges and analyse fundamental mechanisms that limit, or otherwise affect, the evolution of a European social dimension. These insights clarify the far-reaching measures that will be needed to gradually restore the balance between market integration and social protection across the European Union. Illustrating the importance of cohesion, this book is vital for those interested in comparative European studies, from backgrounds in public and social policy, law and economics. 
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10.
  • Karlsson, Christer, Professor, 1965-, et al. (författare)
  • Dimensions of disagreement in EU affairs : is parliamentary opposition driven by left-right or European integration contestation?
  • 2024
  • Ingår i: West European Politics. - 0140-2382 .- 1743-9655.
  • Tidskriftsartikel (refereegranskat)abstract
    • This study provides new insights regarding how the EU dimension relates to the left-right dimension in national politics. It does so by examining to what extent parties’ oppositional behaviour in EU affairs in parliament is a function of their distance to the government, other parties, the voters and party supporters on the EU dimension and the left-right dimension, respectively. The results suggest that oppositional behaviour is determined by two parallel dynamics: When expressing opposition, political parties are receptive both to the positions of the government and other parties on the EU dimension, and to the positions of voters and supporters on the left-right dimension. Our results thus indicate that the politicization of EU affairs in national parliaments primarily is an elite phenomenon. In their relation to the voters and supporters, parties still primarily navigate along the traditional left-right dimension.
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