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Immunohistochemical Expression of BRCA1 and Lethal Prostate Cancer

Fiorentino, Michelangelo (author)
Department of Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
Judson, Gregory (author)
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA; Department of Epidemiology, Harvard School of Public Health, Boston, USA
Penney, Kathryn (author)
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA; Department of Epidemiology, Harvard School of Public Health, Boston, USA
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Flavin, Richard (author)
Department of Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
Stark, Jennifer (author)
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA; Department of Epidemiology, Harvard School of Public Health, Boston, USA
Fiore, Christopher (author)
Department of Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
Fall, Katja, 1971- (author)
Karolinska Institutet,Uppsala University Hospital
Martin, Neil (author)
Department of Epidemiology, Harvard School of Public Health, Boston, USA; Radiation Oncology, Brigham and Women's Hospital, Boston, USA
Ma, Jing (author)
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA
Sinnott, Jennifer (author)
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA; Department of Biostatistics, Harvard School of Public Health, Boston, USA
Giovannucci, Edward (author)
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA; Department of Epidemiology, Harvard School of Public Health, Boston, USA; Department of Nutrition, Harvard School of Public Health, Boston, USA
Stampfer, Meir (author)
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA; Department of Epidemiology, Harvard School of Public Health, Boston, USA; Department of Nutrition, Harvard School of Public Health, Boston, USA
Sesso, Howard D. (author)
Department of Epidemiology, Harvard School of Public Health, Boston, USA; Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA
Kantoff, Philip W. (author)
Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA; Broad Institute, Cambridge, USA
Finn, Stephen (author)
Department of Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
Loda, Massimo (author)
Department of Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA; Broad Institute, Cambridge, USA
Mucci, Lorelei (author)
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA; Department of Epidemiology, Harvard School of Public Health, Boston, USA
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 (creator_code:org_t)
Philadelphia, USA : American Association for Cancer Research, 2010
2010
English.
In: Cancer Research. - Philadelphia, USA : American Association for Cancer Research. - 0008-5472 .- 1538-7445. ; 70:8, s. 3136-3139
Related links:
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • BRCA1 functions as a tumor suppressor; recent work suggests that BRCA1 may also induce cell cycle arrest to allow for DNA repair. We hypothesized that BRCA1 expression in prostate tumor tissue may be associated with prostate cancer progression through regulation of the cell cycle. We used immunohistochemistry to evaluate BRCA1 protein expression in archival tumor samples from 393 prostate cancer cases in the Physicians' Health Study. The men were followed prospectively from diagnosis to development of metastases and mortality. Fifteen percent of tumors stained positive for BRCA1. BRCA1-positive tumors had substantially increased tumor proliferation index compared with negative tumors (47.0 Ki67-positive nuclei versus 10.3, P = 0.0016) and were more likely to develop lethal cancer compared with BRCA1-negative tumors (hazard ratio, 4.6; 95% confidence interval, 2.4-8.7). These findings strengthen the hypothesis that BRCA1 plays a role in cell cycle control and show that BRCA1 is a marker of clinical prostate cancer prognosis. Cancer Res; 70(8); 3136-9. (C) 2010 AACR.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Keyword

MEDICINE
MEDICIN

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