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Maternal stress alt...
Maternal stress alters endocrine function of the feto-placental unit in rats.
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Mairesse, Jérôme (author)
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Lesage, Jean (author)
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Breton, Christophe (author)
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Bréant, Bernadette (author)
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Hahn, Tom (author)
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Darnaudéry, Muriel (author)
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- Dickson, Suzanne L., 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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Seckl, Jonathan (author)
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Blondeau, Bertrand (author)
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Vieau, Didier (author)
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Maccari, Stefania (author)
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Viltart, Odile (author)
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(creator_code:org_t)
- American Physiological Society, 2007
- 2007
- English.
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In: American journal of physiology. Endocrinology and metabolism. - : American Physiological Society. - 0193-1849 .- 1522-1555. ; 292:6
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Prenatal stress (PS) can cause early and long-term developmental effects resulting in part from altered maternal and/or fetal glucocorticoid exposure. The aim of the present study was to assess the impact of chronic restraint stress during late gestation on feto-placental unit physiology and function in embryonic (E) day 21 male rat fetuses. Chronic stress decreased body weight gain and food intake of the dams and increased their adrenal weight. In the placenta of PS rats, the expression of glucose transporter type 1 (GLUT1) was decreased, whereas GLUT3 and GLUT4 were slightly increased. Moreover, placental expression and activity of the glucocorticoid "barrier" enzyme 11beta-hydroxysteroid dehydrogenase type 2 was strongly reduced. At E21, PS fetuses exhibited decreased body, adrenal pancreas, and testis weights. These alterations were associated with reduced pancreatic beta-cell mass, plasma levels of glucose, growth hormone, and ACTH, whereas corticosterone, insulin, IGF-1, and CBG levels were unaffected. These data emphasize the impact of PS on both fetal growth and endocrine function as well as on placental physiology, suggesting that PS could program processes implied in adult biology and pathophysiology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- 11-beta-Hydroxysteroid Dehydrogenase Type 2
- metabolism
- Adrenal Glands
- pathology
- Animals
- Blood Glucose
- metabolism
- Body Weight
- Chronic Disease
- Eating
- Endocrine Glands
- embryology
- Female
- Fetal Blood
- metabolism
- Fetus
- anatomy & histology
- metabolism
- Glucose Transport Proteins
- Facilitative
- metabolism
- Hormones
- blood
- Insulin-Secreting Cells
- cytology
- Islets of Langerhans
- embryology
- Male
- Organ Size
- Pancreas
- embryology
- Placenta
- metabolism
- Pregnancy
- Pregnancy Complications
- metabolism
- pathology
- physiopathology
- Rats
- Restraint
- Physical
- Stress
- etiology
- metabolism
- pathology
- physiopathology
- Testis
- embryology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Mairesse, Jérôme
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Lesage, Jean
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Breton, Christop ...
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Bréant, Bernadet ...
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Hahn, Tom
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Darnaudéry, Muri ...
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show more...
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Dickson, Suzanne ...
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Seckl, Jonathan
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Blondeau, Bertra ...
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Vieau, Didier
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Maccari, Stefani ...
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Viltart, Odile
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Physiology
- Articles in the publication
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American journal ...
- By the university
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University of Gothenburg