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Sökning: WFRF:(Magnusson P) > Högskolan i Gävle

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2.
  • Dumanski, Jan P., et al. (författare)
  • Smoking is associated with mosaic loss of chromosome Y
  • 2015
  • Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 347:6217, s. 81-83
  • Tidskriftsartikel (refereegranskat)abstract
    • Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared to females. This observation, together with the fact that males have a higher incidence of and mortality from most non-sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% CI = 2.8-6.7; ULSAM: OR = 2.4, 95% CI = 1.6-3.6; and PIVUS: OR = 3.5, 95% CI = 1.4-8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation.
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3.
  • Cornelissen, Johannes H C, et al. (författare)
  • Global negative vegetation feedback to climate warming responses of leaf litter decomposition rates in cold biomes
  • 2007
  • Ingår i: Ecology Letters. - : Wiley. - 1461-023X .- 1461-0248. ; 10:7, s. 619-627
  • Tidskriftsartikel (refereegranskat)abstract
    • Whether climate change will turn cold biomes from large long-term carbon sinks into sources is hotly debated because of the great potential for ecosystem-mediated feedbacks to global climate. Critical are the direction, magnitude and generality of climate responses of plant litter decomposition. Here, we present the first quantitative analysis of the major climate-change-related drivers of litter decomposition rates in cold northern biomes worldwide.Leaf litters collected from the predominant species in 33 global change manipulation experiments in circum-arctic-alpine ecosystems were incubated simultaneously in two contrasting arctic life zones. We demonstrate that longer-term, large-scale changes to leaf litter decomposition will be driven primarily by both direct warming effects and concomitant shifts in plant growth form composition, with a much smaller role for changes in litter quality within species. Specifically, the ongoing warming-induced expansion of shrubs with recalcitrant leaf litter across cold biomes would constitute a negative feedback to global warming. Depending on the strength of other (previously reported) positive feedbacks of shrub expansion on soil carbon turnover, this may partly counteract direct warming enhancement of litter decomposition.
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4.
  • Halling, Bengt, et al. (författare)
  • Application of a sense of coherence-based leadership for productivity and health at Scania
  • 2019
  • Ingår i: International Journal of Human Factors and Ergonomics. - : Inderscience Enterprises Ltd.. - 2045-7804 .- 2045-7812. ; 6:2, s. 179-194
  • Tidskriftsartikel (refereegranskat)abstract
    • The purpose was to explore if sense of coherence (SOC) theory can be used in human factors ergonomics (HFE) practice as a leadership approach to decrease the rate of sick leave and rehabilitation cases and increase work attendance among assembly personnel without impeding productivity. Via three studies carried out at the Swedish truck manufacturer Scania, we investigated the company’s key performance indicators and documented meetings with managers during the intervention. The results show that SOC can be used in HFE practice and that productivity, quality and attendance at work increased, while rehabilitation cases decreased. Our conclusion is that a health promotion approach among managers is essential in a lean organisation that aims to reduce waste in the company and optimise human capability and thereby productivity. SOC theory can support the creation of workplaces that are high performing and healthy, starting with concerns for the people creating the output.
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