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Cotranslational Pro...
Cotranslational Protein Folding inside the Ribosome Exit Tunnel
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- Nilsson, Ola B. (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Ctr Biomembrane Res, Dept Biochem & Biophys, S-10691 Stockholm, Sweden.
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- Hedman, Rickard (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Ctr Biomembrane Res, Dept Biochem & Biophys, S-10691 Stockholm, Sweden.
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- Marino, Jacopo (author)
- Univ Munich, CiPS M, Gene Ctr, D-81377 Munich, Germany.;Univ Munich, CiPS M, Ctr Integrated Prot Sci Munich, D-81377 Munich, Germany.
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- Wickles, Stephan (author)
- Univ Munich, CiPS M, Gene Ctr, D-81377 Munich, Germany.;Univ Munich, CiPS M, Ctr Integrated Prot Sci Munich, D-81377 Munich, Germany.
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- Bischoff, Lukas (author)
- Univ Munich, CiPS M, Gene Ctr, D-81377 Munich, Germany.;Univ Munich, CiPS M, Ctr Integrated Prot Sci Munich, D-81377 Munich, Germany.
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- Johansson, Magnus (author)
- Uppsala universitet,Struktur- och molekylärbiologi,Beräknings- och systembiologi
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- Müller-Lucks, Annika (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Ctr Biomembrane Res, Dept Biochem & Biophys, S-10691 Stockholm, Sweden.
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- Trovato, Fabio (author)
- Penn State Univ, Dept Chem, University Pk, PA 16802 USA.
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- Puglisi, Joseph D. (author)
- Stanford Univ, Sch Med, Dept Biol Struct, Stanford, CA 94305 USA.;Stanford Univ, Sch Med, Stanford Magnet Resonance Lab, Stanford, CA 94305 USA.
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- O’Brien, Edward P. (author)
- Penn State Univ, Dept Chem, University Pk, PA 16802 USA.
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- Beckmann, Roland (author)
- Univ Munich, CiPS M, Gene Ctr, D-81377 Munich, Germany.;Univ Munich, CiPS M, Ctr Integrated Prot Sci Munich, D-81377 Munich, Germany.
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- von Heijne, Gunnar (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Stockholm Univ, Ctr Biomembrane Res, Dept Biochem & Biophys, S-10691 Stockholm, Sweden.;Stockholm Univ, Sci Life Lab, S-17121 Solna, Sweden.
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(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- English.
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In: Cell Reports. - : Elsevier BV. - 2211-1247. ; 12:10, s. 1533-1540
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Abstract
Subject headings
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- At what point during translation do proteins fold? It is well established that proteins can fold cotranslationally outside the ribosome exit tunnel, whereas studies of folding inside the exit tunnel have so far detected only the formation of helical secondary structure and collapsed or partially structured folding intermediates. Here, using a combination of co-translational nascent chain force measurements, inter-subunit fluorescence resonance energy transfer studies on single translating ribosomes, molecular dynamics simulations, and cryoelectron microscopy, we show that a small zinc-finger domain protein can fold deep inside the vestibule of the ribosome exit tunnel. Thus, for small protein domains, the ribosome itself can provide the kind of sheltered folding environment that chaperones provide for larger proteins.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biofysik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biophysics (hsv//eng)
Keyword
- Ribosome
- Protein Folding
- Cotranslational Folding
- Translation
- SecM
- Cryo-EM
- Biochemistry
- biokemi
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Nilsson, Ola B.
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Hedman, Rickard
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Marino, Jacopo
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Wickles, Stephan
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Bischoff, Lukas
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Johansson, Magnu ...
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Müller-Lucks, An ...
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Trovato, Fabio
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Puglisi, Joseph ...
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O’Brien, Edward ...
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Beckmann, Roland
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von Heijne, Gunn ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Cell Biology
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biophysics
- Articles in the publication
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Cell Reports
- By the university
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Stockholm University
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Uppsala University