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Epidemiology and ca...
Epidemiology and causes of death in a Swedish cohort of patients with autoimmune hepatitis
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- Danielsson Borssén, Åsa (författare)
- Umeå universitet,Medicin
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- Marschall, Hanns-Ulrich (författare)
- Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg
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- Bergquist, Annika (författare)
- Department of Medicine, Section of Hepatology and Gastroenterology, Karolinska Institutet, Karolinska University Hospital Huddinge
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- Rorsman, Fredrik (författare)
- Department of Medical Sciences, Section of Gastroenterology and Hepatology, Uppsala University
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- Weiland, Ola (författare)
- Division of Infectious Diseases, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge
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- Kechagias, Stergios (författare)
- Department of Gastroenterology and Hepatology, Department of Medical and Health Sciences, Linköping University
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- Nyhlin, Nils (författare)
- Department of Gastroenterology, Faculty of Medicine and Health, Örebro University
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- Verbaan, Hans (författare)
- Gastroenterology Division, Department of Clinical Sciences, Lund University, University Hospital Skane
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- Nilsson, Emma (författare)
- Gastroenterology Division, Department of Clinical Sciences, Lund University, University Hospital Skane
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- Werner, Mårten (författare)
- Umeå universitet,Medicin
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(creator_code:org_t)
- Engelska.
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Background Epidemiological studies of autoimmune hepatitis (AIH) show varying figures on prevalence and incidence, and data on the long-term prognosis are scarce.Objective To investigate the epidemiology, long-term prognosis and causes of death in a Swedish AIH cohort.Material and methods Data collected from 634 AIH patients were matched to the Cause of Death Registry, and survival analyses were made. Prevalence and incidence were calculated for University Hospitals with full coverage of cases and compared to the County of Västerbotten in Northern Sweden.Results AIH point prevalence was 17.3/100 000 inhabitants in 2009, and the yearly incidence 1990-2009 was 1.2/100 000 inhabitants and year. The time between diagnosis and end of follow-up, liver transplantation or death was in median 11.3 years (range 0-51.5 years). Men were diagnosed earlier (p<0.001) and died younger than women (p=0.002). No gender differences were found concerning transplant-free, overall survival and liver-related death. Cirrhosis at diagnosis was linked to an inferior survival (p<0.001). Liver-related death was the most common cause of death (32.7%). The relative survival started to diverge from the general population 4 years after diagnosis but a distinct decline was not observed until after more than 10 years. Conclusions Long-term survival was reduced in patients with AIH. No gender difference regarding prognosis was seen but men died younger, probably as a result of earlier onset of disease. Cirrhosis at diagnosis was a risk factor for poor prognosis and the overall risk of liver-related death was increased.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
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