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- Bousquet, Jean, et al.
(författare)
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Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018) : Change management in allergic rhinitis and asthma multimorbidity using mobile technology
- 2019
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Ingår i: Journal of Allergy and Clinical Immunology. - : Elsevier. - 0091-6749 .- 1097-6825. ; 143:3, s. 864-879
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Tidskriftsartikel (refereegranskat)abstract
- Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline by using the best approach to integrated care pathways using mobile technology in patients with allergic rhinitis (AR) and asthma multimorbidity. The proposed next phase of ARIA is change management, with the aim of providing an active and healthy life to patients with rhinitis and to those with asthma multimorbidity across the lifecycle irrespective of their sex or socioeconomic status to reduce health and social inequities incurred by the disease. ARIA has followed the 8-step model of Kotter to assess and implement the effect of rhinitis on asthma multimorbidity and to propose multimorbid guidelines. A second change management strategy is proposed by ARIA Phase 4 to increase self-medication and shared decision making in rhinitis and asthma multimorbidity. An innovation of ARIA has been the development and validation of information technology evidence-based tools (Mobile Airways Sentinel Network [MASK]) that can inform patient decisions on the basis of a self-care plan proposed by the health care professional.
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- Hotchkiss, Erin, et al.
(författare)
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Modeling priming effects on microbial consumption of dissolved organic carbon in rivers
- 2014
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Ingår i: Journal of Geophysical Research - Biogeosciences. - 2169-8953 .- 2169-8961. ; 119:5, s. 982-995
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Tidskriftsartikel (refereegranskat)abstract
- Rivers receive and process large quantities of terrestrial dissolved organic carbon (DOC). Biologically available (unstable) DOC leached from primary producers may stimulate (i.e., prime) the consumption of more stable terrestrially derived DOC by heterotrophic microbes. We measured microbial DOC consumption (i.e., decay rates) from contrasting C sources in 10 rivers in the western and Midwestern United States using short-term bioassays of river water, soil and algal leachates, glucose, and commercial humate. We added inorganic nutrients (ammonium and phosphorus) to a subset of bioassays. We also amended a subset of river, soil, and commercial humate bioassays with glucose or algal leachates to test the hypothesis that unstable DOC primes consumption of more stable DOC. We used prior measurements of source-specific DOC bioavailability, linked with a Bayesian process model, to estimate means and posterior probability distributions for source-specific DOC decay rates in multisource bioassays. Modeled priming effects ranged from a -130 to +370% change in more stable DOC decay when incubated with unstable DOC. Glucose increased modeled river DOC decay by an average of 87% among all rivers. Glucose and algal leachates increased soil leachate and commercial humate decay by an average of 25% above background rates. Inorganic nutrient additions did not have consistent effects on DOC decay, likely because most of the study rivers had high ambient background nutrients. Our results demonstrate that the priming effect can augment DOC decay in rivers. In addition, Bayesian models can be used to estimate mechanisms driving aquatic ecosystem processes that are difficult to measure directly.
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- Menditto, Enrica, et al.
(författare)
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Adherence to treatment in allergic rhinitis using mobile technology : The MASK Study
- 2019
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Ingår i: Clinical and Experimental Allergy. - : WILEY. - 0954-7894 .- 1365-2222. ; 49:4, s. 442-460
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Tidskriftsartikel (refereegranskat)abstract
- Background: Mobile technology may help to better understand the adherence to treatment. MASK-rhinitis (Mobile Airways Sentinel NetworK for allergic rhinitis) is a patient-centred ICT system. A mobile phone app (the Allergy Diary) central to MASK is available in 22 countries. Objectives: To assess the adherence to treatment in allergic rhinitis patients using the Allergy Diary App. Methods: An observational cross-sectional study was carried out on all users who filled in the Allergy Diary from 1 January 2016 to 1 August 2017. Secondary adherence was assessed by using the modified Medication Possession Ratio (MPR) and the Proportion of days covered (PDC) approach. Results: A total of 12143 users were registered. A total of 6949 users reported at least one VAS data recording. Among them, 1887 users reported >= 7 VAS data. About 1195 subjects were included in the analysis of adherence. One hundred and thirty-six (11.28%) users were adherent (MPR >= 70% and PDC <= 1.25), 51 (4.23%) were partly adherent (MPR >= 70% and PDC = 1.50) and 176 (14.60%) were switchers. On the other hand, 832 (69.05%) users were non-adherent to medications (MPR <70%). Of those, the largest group was non-adherent to medications and the time interval was increased in 442 (36.68%) users. Conclusion and clinical relevance: Adherence to treatment is low. The relative efficacy of continuous vs on-demand treatment for allergic rhinitis symptoms is still a matter of debate. This study shows an approach for measuring retrospective adherence based on a mobile app. This also represents a novel approach for analysing medication-taking behaviour in a real-world setting.
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