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International consensus on antineutrophil cytoplasm antibodies testing in eosinophilic granulomatosis with polyangiitis

Moiseev, Sergey (author)
I.M. Sechenov First Moscow State Medical University
Bossuyt, Xavier (author)
University Hospitals Leuven,Catholic University of Leuven
Arimura, Yoshihiro (author)
Kyorin University
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Blockmans, Daniel (author)
University Hospitals Leuven
Csernok, Elena (author)
Medius Klinik Kirchheim,University of Tübingen
Damoiseaux, Jan (author)
Maastricht University Medical Centre
Emmi, Giacomo (author)
University of Florence,Careggi University Hospital
Flores-Suarez, Luis Felipe (author)
Instituto Nacional de Enfermedades Respiratorias
Hellmich, Bernhard (author)
University Hospital of Tubingen,University of Tübingen
Jayne, David (author)
University of Cambridge
Charles Jennette, J. (author)
University of North Carolina
Little, Mark A. (author)
Trinity Translational Medicine Institute
Mohammad, Aladdin J. (author)
Addenbrooke's Hospital,Skåne University Hospital
Moosig, Frank (author)
Rheumazentrum Schleswig-Holstein Mitte
Novikov, Pavel (author)
I.M. Sechenov First Moscow State Medical University
Pagnoux, Christian (author)
University of Toronto,Mount Sinai Hospital of University of Toronto
Radice, Antonella (author)
San Carlo Borromeo Hospital, Milan
Sada, Ken Ei (author)
Okayama University
Segelmark, Marten (author)
Lund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
Shoenfeld, Yehuda (author)
Tel-Aviv University,I.M. Sechenov First Moscow State Medical University,Sheba Medical Center
Sinico, Renato A. (author)
University of Milano-Bicocca
Specks, Ulrich (author)
Mayo Clinic Minnesota
Terrier, Benjamin (author)
Cochin Hospital
Tzioufas, Athanasios G. (author)
National and Kapodistrian University of Athens
Vaglio, Augusto (author)
University of Florence,Meyer Children's Hospital
Zhao, Ming Hui (author)
Peking University First Hospital,Peking-Tsinghua Center for Life Sciences
Tervaert, Jan Willem Cohen (author)
Maastricht University,University of Alberta
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IM. Sechenov First Moscow State Medical University University Hospitals Leuven (creator_code:org_t)
2020
2020
English 13 s.
In: American Journal of Respiratory and Critical Care Medicine. - 1073-449X. ; 202:10, s. 1360-1372
Related links:
http://dx.doi.org/10...
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https://lup.lub.lu.s...
https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • An international consensus on antineutrophil cytoplasm antibodies (ANCA) testing in eosinophilic granulomatosiswith polyangiitis (EGPA) is presented.ANCA, specific formyeloperoxidase (MPO), can be detected in 30-35% of patients with EGPA. MPO-ANCA should be tested with antigen-specific immunoassays in any patient with eosinophilic asthma and clinical features suggesting EGPA, including constitutional symptoms; purpura; polyneuropathy; unexplained heart, gastrointestinal, or kidney disease; and/or pulmonary infiltrates or hemorrhage.Apositive MPO-ANCA result contributes to the diagnostic workup for EGPA. Patients with MPO-ANCA-associated EGPA have vasculitis features, such as glomerulonephritis, neuropathy, and skin manifestations, more frequently than patients with ANCA-negative EGPA. However, the presence of MPO-ANCA is neither sensitive nor specific enough to identifywhether a patient should be subclassified as having "vasculitic"or "eosinophilic"EGPA. At present, ANCA status cannot guide treatment decisions, that is,whether cyclophosphamide, rituximab, ormepolizumab should be added to conventional glucocorticoid treatment. In EGPA, monitoring of ANCA is only useful when MPO-ANCA was tested positive at disease onset.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)

Keyword

ANCA
Consensus
Eosinophilic granulomatosis with polyangiitis
Vasculitis

Publication and Content Type

art (subject category)
ref (subject category)

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