1. 


2. 
 Barausse, Enrico, et al.
(författare)

Prospects for fundamental physics with LISA
 2020

Ingår i: General Relativity and Gravitation.  : SPRINGER/PLENUM PUBLISHERS.  00017701 . 15729532. ; 52:8

Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
 In this paper, which is of programmatic rather than quantitative nature, we aim to further delineate and sharpen the future potential of the LISA mission in the area of fundamental physics. Given the very broad range of topics that might be relevant to LISA,we present here a sample of what we view as particularly promising fundamental physics directions. We organize these directions through a "sciencefirst" approach that allows us to classify how LISA data can inform theoretical physics in a variety of areas. For each of these theoretical physics classes, we identify the sources that are currently expected to provide the principal contribution to our knowledge, and the areas that need further development. The classification presented here should not be thought of as cast in stone, but rather as a fluid framework that is amenable to change with the flow of new insights in theoretical physics.


3. 


4. 
 Klionsky, Daniel J., et al.
(författare)

Guidelines for the use and interpretation of assays for monitoring autophagy
 2012

Ingår i: Autophagy.  : Informa UK Limited.  15548635 . 15548627. ; 8:4, s. 445544

Forskningsöversikt (refereegranskat)abstract
 In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.


5. 
 Abdalla, E., et al.
(författare)

Cosmology intertwined : A review of the particle physics, astrophysics, and cosmology associated with the cosmological tensions and anomalies
 2022

Ingår i: Journal of High Energy Astrophysics.  : Elsevier BV.  22144048 . 22144056. ; 34, s. 49211

Tidskriftsartikel (refereegranskat)abstract
 The standard Λ Cold Dark Matter (ΛCDM) cosmological model provides a good description of a wide range of astrophysical and cosmological data. However, there are a few big open questions that make the standard model look like an approximation to a more realistic scenario yet to be found. In this paper, we list a few important goals that need to be addressed in the next decade, taking into account the current discordances between the different cosmological probes, such as the disagreement in the value of the Hubble constant H0, the σ8–S8 tension, and other less statistically significant anomalies. While these discordances can still be in part the result of systematic errors, their persistence after several years of accurate analysis strongly hints at cracks in the standard cosmological scenario and the necessity for new physics or generalisations beyond the standard model. In this paper, we focus on the 5.0σ tension between the Planck CMB estimate of the Hubble constant H0 and the SH0ES collaboration measurements. After showing the H0 evaluations made from different teams using different methods and geometric calibrations, we list a few interesting new physics models that could alleviate this tension and discuss how the next decade's experiments will be crucial. Moreover, we focus on the tension of the Planck CMB data with weak lensing measurements and redshift surveys, about the value of the matter energy density Ωm, and the amplitude or rate of the growth of structure (σ8,fσ8). We list a few interesting models proposed for alleviating this tension, and we discuss the importance of trying to fit a full array of data with a single model and not just one parameter at a time. Additionally, we present a wide range of other less discussed anomalies at a statistical significance level lower than the H0–S8 tensions which may also constitute hints towards new physics, and we discuss possible generic theoretical approaches that can collectively explain the nonstandard nature of these signals. Finally, we give an overview of upgraded experiments and nextgeneration space missions and facilities on Earth that will be of crucial importance to address all these open questions.


6. 
 Delabrouille, J., et al.
(författare)

Exploring cosmic origins with CORE : Survey requirements and mission design
 2018

Ingår i: Journal of Cosmology and Astroparticle Physics.  : IOP Publishing.  14757516. ; :4

Tidskriftsartikel (refereegranskat)abstract
 Future observations of cosmic microwave background (CMB) polarisation have the potential to answer some of the most fundamental questions of modern physics and cosmology, including: what physical process gave birth to the Universe we see today? What are the dark matter and dark energy that seem to constitute 95% of the energy density of the Universe? Do we need extensions to the standard model of particle physics and fundamental interactions? Is the ACDM cosmological scenario correct, or are we missing an essential piece of the puzzle? In this paper, we list the requirements for a future CMB polarisation survey addressing these scientific objectives, and discuss the design drivers of the CORE space mission proposed to ESA in answer to the M5 call for a mediumsized mission. The rationale and options, and the methodologies used to assess the mission's performance, are of interest to other future CMB mission design studies. CORE has 19 frequency channels, distributed over a broad frequency range, spanning the 60600 GHz interval, to control astrophysical foreground emission. The angular resolution ranges from 2' to 18', and the aggregate CMB sensitivity is about 2 mu K.arcmin. The observations are made with a single integrated focalplane instrument, consisting of an array of 2100 cryogenicallycooled, linearlypolarised detectors at the focus of a 1.2m aperture crossDragone telescope. The mission is designed to minimise all sources of systematic effects, which must be controlled so that no more than 10(4) of the intensity leaks into polarisation maps, and no more than about 1% of Etype polarisation leaks into Btype modes. CORE observes the sky from a large Lissajous orbit around the SunEarth L2 point on an orbit that offers stable observing conditions and avoids contamination from sidelobe pickup of stray radiation originating from the Sun, Earth, and Moon. The entire sky is observed repeatedly during four years of continuous scanning, with a combination of three rotations of the spacecraft over different timescales. With about 50% of the sky covered every few days, this scan strategy provides the mitigation of systematic effects and the internal redundancy that are needed to convincingly extract the primordial Bmode signal on large angular scales, and check with adequate sensitivity the consistency of the observations in several independent data subsets. CORE is designed as a nearultimate CMB polarisation mission which, for optimal complementarity with groundbased observations, will perform the observations that are known to be essential to CMB polarisation science and cannot be obtained by any other means than a dedicated space mission. It will provide wellcharacterised, highlyredundant multifrequency observations of polarisation at all the scales where foreground emission and cosmic variance dominate the final uncertainty for obtaining precision CMB science, as well as 2' angular resolution maps of highfrequency foreground emission in the 300600 GHz frequency range, essential for complementarity with future groundbased observations with large telescopes that can observe the CMB with the same beamsize.


7. 
 Ade, P. A. R., et al.
(författare)

Planck 2015 results XVIII. Background geometry and topology of the Universe
 2016

Ingår i: Astronomy and Astrophysics.  : EDP Sciences.  00046361 . 14320746. ; 594

Tidskriftsartikel (refereegranskat)abstract
 Maps of cosmic microwave background (CMB) temperature and polarization from the 2015 release of Planck data provide the highest quality fullsky view of the surface of last scattering available to date. This enables us to detect possible departures from a globally isotropic cosmology. We present the first searches using CMB polarization for correlations induced by a possible nontrivial topology with a fundamental domain that intersects, or nearly intersects, the lastscattering surface (at comoving distance chi(rec)), both via a direct scan for matched circular patterns at the intersections and by an optimal likelihood calculation for specific topologies. We specialize to flat spaces with cubic toroidal (T3) and slab (T1) topologies, finding that explicit searches for the latter are sensitive to other topologies with antipodal symmetry. These searches yield no detection of a compact topology with a scale below the diameter of the lastscattering surface. The limits on the radius Ri of the largest sphere inscribed in the fundamental domain (at loglikelihood ratio Delta ln L > 5 relative to a simplyconnected flat Planck bestfit model) are: Ri > 0.97 chi(rec) for the T3 cubic torus; and Ri > 0.56 chi(rec) for the T1 slab. The limit for the T3 cubic torus from the matchedcircles search is numerically equivalent, Ri > 0.97 chi(rec) at 99% confidence level from polarization data alone. We also perform a Bayesian search for an anisotropic global Bianchi VIIh geometry. In the nonphysical setting, where the Bianchi cosmology is decoupled from the standard cosmology, Planck temperature data favour the inclusion of a Bianchi component with a Bayes factor of at least 2.3 units of logevidence. However, the cosmological parameters that generate this pattern are in strong disagreement with those found from CMB anisotropy data alone. Fitting the induced polarization pattern for this model to the Planck data requires an amplitude of 0.10 +/ 0.04 compared to the value of + 1 if the model were to be correct. In the physically motivated setting, where the Bianchi parameters are coupled and fitted simultaneously with the standard cosmological parameters, we find no evidence for a Bianchi VIIh cosmology and constrain the vorticity of such models to (omega/H)(0) < 7.6 x 10(10) (95% CL).


8. 
 Ade, P. A. R., et al.
(författare)

XXI. The integrated SachsWolfe effect
 2016

Ingår i: Astronomy and Astrophysics.  : EDP Sciences.  00046361 . 14320746. ; 594

Tidskriftsartikel (refereegranskat)abstract
 This paper presents a study of the integrated SachsWolfe (ISW) effect from the Planck 2015 temperature and polarization data release. This secondary cosmic microwave background (CMB) anisotropy caused by the largescale timeevolving gravitational potential is probed from different perspectives. The CMB is crosscorrelated with different largescale structure (LSS) tracers: radio sources from the NVSS catalogue; galaxies from the optical SDSS and the infrared WISE surveys; and the Planck 2015 convergence lensing map. The joint crosscorrelation of the CMB with the tracers yields a detection at 4 sigma where most of the signaltonoise is due to the Planck lensing and the NVSS radio catalogue. In fact, the ISW effect is detected from the Planck data only at approximate to 3 sigma (through the ISWlensing bispectrum), which is similar to the detection level achieved by combining the crosscorrelation signal coming from all the galaxy catalogues mentioned above. We study the ability of the ISW effect to place constraints on the darkenergy parameters; in particular, we show that Omega(Lambda) is detected at more than 3 sigma. This crosscorrelation analysis is performed only with the Planck temperature data, since the polarization scales available in the 2015 release do not permit significant improvement of the CMBLSS crosscorrelation detectability. Nevertheless, the Planck polarization data are used to study the anomalously large ISW signal previously reported through the aperture photometry on stacked CMB features at the locations of known superclusters and supervoids, which is in conflict with Lambda CDM expectations. We find that the current Planck polarization data do not exclude that this signal could be caused by the ISW effect. In addition, the stacking of the Planck lensing map on the locations of superstructures exhibits a positive crosscorrelation with these largescale structures. Finally, we have improved our previous reconstruction of the ISW temperature fluctuations by combining the information encoded in all the previously mentioned LSS tracers. In particular, we construct a map of the ISW secondary anisotropies and the corresponding uncertainties map, obtained from simulations. We also explore the reconstruction of the ISW anisotropies caused by the largescale structure traced by the 2MASS Photometric Redshift Survey (2MPZ) by directly inverting the density field into the gravitational potential field.


9. 
 Ade, P. A. R., et al.
(författare)

Planck 2015 results XV. Gravitational lensing
 2016

Ingår i: Astronomy and Astrophysics.  : EDP Sciences.  00046361 . 14320746. ; 594

Tidskriftsartikel (refereegranskat)abstract
 We present the most significant measurement of the cosmic microwave background (CMB) lensing potential to date (at a level of 40 sigma), using temperature and polarization data from the Planck 2015 fullmission release. Using a polarizationonly estimator, we detect lensing at a significance of 5 sigma. We crosscheck the accuracy of our measurement using the wide frequency coverage and complementarity of the temperature and polarization measurements. Public products based on this measurement include an estimate of the lensing potential over approximately 70% of the sky, an estimate of the lensing potential power spectrum in bandpowers for the multipole range 40 <= L <= 400, and an associated likelihood for cosmological parameter constraints. We find good agreement between our measurement of the lensing potential power spectrum and that found in the Lambda CDM model that best fits the Planck temperature and polarization power spectra. Using the lensing likelihood alone we obtain a percentlevel measurement of the parameter combination sigma(8) Omega(0.25)(m) = 0.591 +/ 0.021. We combine our determination of the lensing potential with the Emode polarization, also measured by Planck, to generate an estimate of the lensing Bmode. We show that this lensing Bmode estimate is correlated with the Bmodes observed directly by Planck at the expected level and with a statistical significance of 10 sigma, confirming Planck's sensitivity to this known sky signal. We also correlate our lensing potential estimate with the largescale temperature anisotropies, detecting a crosscorrelation at the 3 sigma level, as expected because of dark energy in the concordance Lambda CDM model.


10. 
 Ade, P. A. R., et al.
(författare)

Planck 2015 results XVII. Constraints on primordial nonGaussianity
 2016

Ingår i: Astronomy and Astrophysics.  : EDP Sciences.  00046361 . 14320746. ; 594

Tidskriftsartikel (refereegranskat)abstract
 The Planck full mission cosmic microwave background (CMB) temperature and Emode polarization maps are analysed to obtain constraints on primordial nonGaussianity (NG). Using three classes of optimal bispectrum estimators  separable templatefitting (KSW), binned, and modal we obtain consistent values for the primordial local, equilateral, and orthogonal bispectrum amplitudes, quoting as our final result from temperature alone f(NL)(local) = 2.5 +/ 5.7, f(NL)(equil) = 16 +/ 70, and f(NL)(ortho) = 34 +/ 33 (68% CL, statistical). Combining temperature and polarization data we obtain f(NL)(local) = 0.8 +/ 5.0, f(NL)(equil) = 4 +/ 43, and f(NL)(ortho) = 26 +/ 21 (68% CL, statistical). The results are based on comprehensive crossvalidation of these estimators on Gaussian and nonGaussian simulations, are stable across component separation techniques, pass an extensive suite of tests, and are consistent with estimators based on measuring the Minkowski functionals of the CMB. The effect of timedomain deglitching systematics on the bispectrum is negligible. In spite of these test outcomes we conservatively label the results including polarization data as preliminary, owing to a known mismatch of the noise model in simulations and the data. Beyond estimates of individual shape amplitudes, we present modelindependent, threedimensional reconstructions of the Planck CMB bispectrum and derive constraints on early universe scenarios that generate primordial NG, including general singlefield models of inflation, axion inflation, initial state modifications, models producing parityviolating tensor bispectra, and directionally dependent vector models. We present a wide survey of scaledependent feature and resonance models, accounting for the look elsewhere effect in estimating the statistical significance of features. We also look for isocurvature NG, and find no signal, but we obtain constraints that improve significantly with the inclusion of polarization. The primordial trispectrum amplitude in the local model is constrained to be g(NL)(local) = (9.0 +/ 7.7) x 10(4) (68% CL statistical), and we perform an analysis of trispectrum shapes beyond the local case. The global picture that emerges is one of consistency with the premises of the Lambda CDM cosmology, namely that the structure we observe today was sourced by adiabatic, passive, Gaussian, and primordial seed perturbations.

