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Enumeration	Reference	Cover	Find
1.	2021 swepub:Mat__t
2.	Adams, HHH, et al. (author) Novel genetic loci underlying human intracranial volume identified through genome-wide association 2016 In: Nature neuroscience. - : Springer Science and Business Media LLC. - 1546-1726 .- 1097-6256. ; 19:12, s. 1569-1582 Journal article (peer-reviewed)
3.	Brouwer, RM, et al. (author) Genetic variants associated with longitudinal changes in brain structure across the lifespan 2022 In: Nature neuroscience. - : Springer Science and Business Media LLC. - 1546-1726 .- 1097-6256. ; 25:4, s. 421-432 Journal article (peer-reviewed)
4.	Chauhan, G, et al. (author) Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting 2019 In: Neurology. - 1526-632X. ; 92:5, s. E486-E503 Journal article (peer-reviewed)
5.	Christiansen, C, et al. (author) Enhanced resolution profiling in twins reveals differential methylation signatures of type 2 diabetes with links to its complications 2024 In: EBioMedicine. - 2352-3964. ; 103, s. 105096- Journal article (peer-reviewed)
6.	Davies, G, et al. (author) Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function 2019 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 2068- Journal article (other academic/artistic)abstract Christina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article. This has now been corrected in both the PDF and HTML versions of the article.
7.	de Rojas, I, et al. (author) Author Correction: Common variants in Alzheimer's disease and risk stratification by polygenic risk scores 2023 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 14:1, s. 716- Journal article (other academic/artistic)
8.	Franke, B, et al. (author) Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept 2016 In: Nature neuroscience. - : Springer Science and Business Media LLC. - 1546-1726 .- 1097-6256. ; 19:3, s. 420- Journal article (peer-reviewed)
9.	Hibar, DP, et al. (author) Common genetic variants influence human subcortical brain structures 2015 In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 520:7546, s. 224-U216 Journal article (peer-reviewed)
10.	Hou, JH, et al. (author) Polygenic resilience scores capture protective genetic effects for Alzheimer's disease 2022 In: Translational psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 12:1, s. 296- Journal article (peer-reviewed)abstract Polygenic risk scores (PRSs) can boost risk prediction in late-onset Alzheimer’s disease (LOAD) beyond apolipoprotein E (APOE) but have not been leveraged to identify genetic resilience factors. Here, we sought to identify resilience-conferring common genetic variants in (1) unaffected individuals having high PRSs for LOAD, and (2) unaffected APOE-ε4 carriers also having high PRSs for LOAD. We used genome-wide association study (GWAS) to contrast “resilient” unaffected individuals at the highest genetic risk for LOAD with LOAD cases at comparable risk. From GWAS results, we constructed polygenic resilience scores to aggregate the addictive contributions of risk-orthogonal common variants that promote resilience to LOAD. Replication of resilience scores was undertaken in eight independent studies. We successfully replicated two polygenic resilience scores that reduce genetic risk penetrance for LOAD. We also showed that polygenic resilience scores positively correlate with polygenic risk scores in unaffected individuals, perhaps aiding in staving off disease. Our findings align with the hypothesis that a combination of risk-independent common variants mediates resilience to LOAD by moderating genetic disease risk.

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Type of publication: journal article (19)

Type of content: peer-reviewed (16); other academic/artistic (3)

Author/Editor: Mather, KA (18); Sachdev, PS (17); Armstrong, NJ (11); Andreassen, OA (9); Brodaty, H (9); Boomsma, DI (8); show more...; Thompson, PM (8); Ames, D (8); Ophoff, RA (7); Seshadri, S (7); Bis, JC (7); Cichon, S (7); Djurovic, S (6); Pedersen, NL (6); Hibar, DP (6); Luciano, M (6); Adams, HHH (6); Wittfeld, K (6); Van der Lee, SJ (6); Ehrlich, S (6); Satizabal, CL (6); Van Eijk, KR (6); Amouyel, P (6); Bastin, ME (6); Crespo-Facorro, B (6); de Zubicaray, GI (6); Donohoe, G (6); Espeseth, T (6); Grabe, HJ (6); Kwok, JB (6); Hottenga, JJ (5); Schmidt, H. (5); Agartz, I (5); Westlye, LT (5); van Duijn, CM (5); Jahanshad, N (5); Soininen, H (5); Stein, JL (5); Desrivieres, S (5); Teumer, A (5); Assareh, AA (5); Cahn, W (5); Dale, AM (5); Fisher, SE (5); Glahn, DC (5); Gudnason, V (5); Hansell, NK (5); Hardy, J (5); Heinz, A (5); Le Hellard, S (5); show less...

University: Karolinska Institutet (20); Umeå University (3); Uppsala University (2); University of Gothenburg (1); Stockholm University (1); Jönköping University (1); show more...; Lund University (1); Stockholm School of Economics (1); show less...

Language: English (20)

Research subject (UKÄ/SCB): Medical and Health Sciences (8); Natural sciences (1)

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