| 1. |
|
|
| 2. |
- Hoyberget, Magne, et al.
(författare)
-
The Skyberg Lagerstatte from the Mjosa area, Norway : a rare window into the late early Cambrian biodiversity of Scandinavia
- 2023
-
Ingår i: Lethaia. - : Scandinavian University Press / Universitetsforlaget AS. - 0024-1164 .- 1502-3931. ; 56:2, s. 1-28
-
Tidskriftsartikel (refereegranskat)abstract
- The Skyberg Biota is a new early Cambrian Konservat-Lagerstatte, documented from a 7.5-m-thick succession of the Skyberg Member, Ringstranda Formation, in the classical Mjosa area of Norway. It displays a high species diversity and contains: algae; sponges; brachiopods; hyoliths; bivalved arthropods; trilobites; palaeoscolecids and other vermiform organisms; weakly sclerotized fragments of unknown affinity; several tubicolous fossils; the enigmatic genus Lapworthella; and a number of additional problematica together with infrequent trace fossils consisting of burrows and faecal pellets. This novel macro-biota encloses the most diverse fossil assemblage known from the Cambrian Series 2 locally in the Mjosa area, and regionally in Baltoscandia, and currently includes around 50 species of 10 major animal groups and macro-algae. The Skyberg Biota contains taxa previously unknown from Norway, several are new to Baltoscandia and also includes a range of new species. The Skyberg biota offers a rare glimpse into the biodiversity of Baltoscandia just prior to the large faunal turnover at the late-middle Cambrian transition.
|
|
| 3. |
- Joffrin, E., et al.
(författare)
-
Overview of the JET preparation for deuterium-tritium operation with the ITER like-wall
- 2019
-
Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 59:11
-
Forskningsöversikt (refereegranskat)abstract
- For the past several years, the JET scientific programme (Pamela et al 2007 Fusion Eng. Des. 82 590) has been engaged in a multi-campaign effort, including experiments in D, H and T, leading up to 2020 and the first experiments with 50%/50% D-T mixtures since 1997 and the first ever D-T plasmas with the ITER mix of plasma-facing component materials. For this purpose, a concerted physics and technology programme was launched with a view to prepare the D-T campaign (DTE2). This paper addresses the key elements developed by the JET programme directly contributing to the D-T preparation. This intense preparation includes the review of the physics basis for the D-T operational scenarios, including the fusion power predictions through first principle and integrated modelling, and the impact of isotopes in the operation and physics of D-T plasmas (thermal and particle transport, high confinement mode (H-mode) access, Be and W erosion, fuel recovery, etc). This effort also requires improving several aspects of plasma operation for DTE2, such as real time control schemes, heat load control, disruption avoidance and a mitigation system (including the installation of a new shattered pellet injector), novel ion cyclotron resonance heating schemes (such as the three-ions scheme), new diagnostics (neutron camera and spectrometer, active Alfven eigenmode antennas, neutral gauges, radiation hard imaging systems...) and the calibration of the JET neutron diagnostics at 14 MeV for accurate fusion power measurement. The active preparation of JET for the 2020 D-T campaign provides an incomparable source of information and a basis for the future D-T operation of ITER, and it is also foreseen that a large number of key physics issues will be addressed in support of burning plasmas.
|
|
| 4. |
- Rodrigues, Joana M., et al.
(författare)
-
p53 is associated with high-risk and pinpointsTP53missense mutations in mantle cell lymphoma
- 2020
-
Ingår i: British Journal of Haematology. - : WILEY. - 0007-1048 .- 1365-2141. ; 191:5, s. 796-805
-
Tidskriftsartikel (refereegranskat)abstract
- Survival for patients diagnosed with mantle cell lymphoma (MCL) has improved drastically in recent years. However, patients carrying mutations in tumour protein p53 (TP53) do not benefit from modern chemotherapy-based treatments and have poor prognosis. Thus, there is a clinical need to identify missense mutations through routine analysis to enable patient stratification. Sequencing is not widely implemented in clinical practice for MCL, and immunohistochemistry (IHC) is a feasible alternative to identify high-risk patients. The aim of the present study was to investigate the accuracy of p53 as a tool to identify patients withTP53missense mutations and the prognostic impact of overexpression and mutations in a Swedish population-based cohort. In total, 317 cases were investigated using IHC and 255 cases were sequenced, enabling analysis of p53 andTP53status among 137 cases divided over the two-cohort investigated. The accuracy of predicting missense mutations from protein expression was 82%, with sensitivity at 82% and specificity at 100% in paired samples. We further show the impact of p53 expression andTP53mutations on survival (hazard ratio of 3 center dot 1 in univariate analysis for both), and the association to risk factors, such as high MCL International Prognostic Index, blastoid morphology and proliferation, in a population-based setting.
|
|
| 5. |
- Öhman, May-Britt, 1966-
(författare)
-
Taming exotic beauties : Swedish hydropower constructions in Tanzania in the era of development assistance, 1960s-1990s
- 2007
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This study analyses the history of a large hydroelectric scheme – the Great Ruaha power project in Tanzania. The objective is to establish why and how this specific scheme came about, and as part of this to identify the key actors involved in the decision-making process, including the ideological contexts within which they acted. Although the Tanzanian actors and the World Bank (IBRD) are discussed, main focus is on the Swedish actors on project level.Kidatu, the first phase of the Great Ruaha power project (constructed between1970-1975), became the first large-scale hydropower station in Tanzania. As such, it paved the way for Tanzanian entrance into the Big Dam Era and significant changes within the Tanzanian landscape. As well as the dry river bed at Kidatu, and the small reservoir that precedes it, the Great Ruaha power project also involved the creation of a huge artificial lake, the Mtera reservoir. The Kidatu hydropower station was the first large undertaking within Swedish bilateral aid, and implied the takeover of control of hydropower construction in Tanzania by Swedish enterprises, replacing the enterprises of the former colonial power. A hydropower plant is a complex technoscientific artefact. The construction of a hydropower plant is preceded by a large number of technological choices, scientific prestudies and estimations of costs and revenues. A hydropower plant is also a complex social creation, and is as such filled with social actors engaged in conflicts, compromises and power structures. The decision to construct Kidatu hydropower station was a result of negotiations and activities within what is called “development assistance”. This brings in yet another dimension, the political one, involving export and import of technology, foreign capital, and foreign influence in decision-making processes, as well as ideas about how to bring development and progress to a people supposed to be living in “poverty and misery”. The study is divided into three main parts. The first part analyses the context of Swedish development assistance in the support to the construction of hydropower plants. This part discusses Swedish state-supported hydropower exploitation of indigenous people’s territory within Sweden’s borders in the 20th century and the background of Swedish development assistance, from the 1950s to the early 1960s. The second part analyses the event of Swedish development assistance entering Tanzania and the Great Ruaha power project, with the main focus being on the period 1965 – 1970. The third part is an analysis of the technoscientific basis for the decisions taken to implement the Great Ruaha hydropower scheme. Main focus is on the period 1969-1974, discussed against the backdrop of precolonial and colonial studies. While focus is on the 1960s and 1970s, in both part two and three events in the 1980s and 1990s are discussed. The study shows that although Sweden was not a colonial power in Tanzania, colonial imagery, and relations to the colonial era, as well as Sweden’s background of internal colonialisation, exerted an influence on the decision-making process and the actors involved in the Great Ruaha power project.The study is mainly based on archival sources, complemented with oral sources from Tanzania and Sweden. Recognizing the complexity of large-scale hydropower and the attempts to control watercourses that large scale hydropower necessitates, in the specific context of decolonisation and development assistance that the decision-making process behind the Great Ruaha hydropower scheme reveals, the analysis of the actors involved is based on feminist and postcolonial perspectives.
|
|
