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Genotype-dependent ...
Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence
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- Meng, Weida (author)
- Fudan Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, MOE Key Lab Metab & Mol Med, Shanghai, Peoples R China.;Fudan Univ, Zhongshan Hosp, Shanghai, Peoples R China.;Fudan Univ, Inst Brain Sci, Frontiers Ctr Brain Sci, State Key Lab Med Neurobiol, Shanghai, Peoples R China.;Fudan Univ, Inst Brain Sci, Frontiers Ctr Brain Sci, MOE, Shanghai, Peoples R China.
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- Sjoholm, Louise K. (author)
- Karolinska Institutet,Karolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Stockholm, Sweden.
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- Kononenko, Olga (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Tay, Nicole (author)
- Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, Ctr Populat Neurosci & Stratified Med PONS, London, England.
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- Zhang, Dandan (author)
- Fudan Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, MOE Key Lab Metab & Mol Med, Shanghai, Peoples R China.;Fudan Univ, Zhongshan Hosp, Shanghai, Peoples R China.;Fudan Univ, Inst Brain Sci, Frontiers Ctr Brain Sci, State Key Lab Med Neurobiol, Shanghai, Peoples R China.;Fudan Univ, Inst Brain Sci, Frontiers Ctr Brain Sci, MOE, Shanghai, Peoples R China.
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- Sarkisyan, Daniil (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Geske, Jennifer R. (author)
- Karolinska Institutet,Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA.
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- Ing, Alex (author)
- Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, Ctr Populat Neurosci & Stratified Med PONS, London, England.
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- Qiu, Wenqing (author)
- Fudan Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, MOE Key Lab Metab & Mol Med, Shanghai, Peoples R China.;Fudan Univ, Zhongshan Hosp, Shanghai, Peoples R China.;Fudan Univ, Inst Brain Sci, Frontiers Ctr Brain Sci, State Key Lab Med Neurobiol, Shanghai, Peoples R China.;Fudan Univ, Inst Brain Sci, Frontiers Ctr Brain Sci, MOE, Shanghai, Peoples R China.
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- Watanabe, Hiroyuki (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Almamoun, Radwa (author)
- Karolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Stockholm, Sweden.
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- Frieling, Helge (author)
- Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Hannover, Germany.
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- Bleich, Stefan (author)
- Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Hannover, Germany.
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- Cui, Donghong (author)
- Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Shanghai, Peoples R China.
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- Biernacka, Joanna M. (author)
- Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA.
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- Mayfield, R. Dayne (author)
- Univ Texas Austin, Waggoner Ctr Alcohol & Addict Res, Austin, TX 78712 USA.
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- Dang, Yongjun (author)
- Fudan Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, MOE Key Lab Metab & Mol Med, Shanghai, Peoples R China.;Fudan Univ, Zhongshan Hosp, Shanghai, Peoples R China.
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- Karpyak, Victor M. (author)
- Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA.
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- Schumann, Gunter (author)
- Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, Ctr Populat Neurosci & Stratified Med PONS, London, England.
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- Bakalkin, Georgy (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Ekstrom, Tomas J. (author)
- Karolinska Institutet,Karolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Stockholm, Sweden.
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- Ruegg, Joelle (author)
- Karolinska Inst, Inst Environm Med, Stockholm, Sweden.
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- Liu, Yun (author)
- Fudan Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, MOE Key Lab Metab & Mol Med, Shanghai, Peoples R China.;Fudan Univ, Zhongshan Hosp, Shanghai, Peoples R China.;Fudan Univ, Inst Brain Sci, Frontiers Ctr Brain Sci, State Key Lab Med Neurobiol, Shanghai, Peoples R China.;Fudan Univ, Inst Brain Sci, Frontiers Ctr Brain Sci, MOE, Shanghai, Peoples R China.
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Karolinska Institutet Fudan Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, MOE Key Lab Metab & Mol Med, Shanghai, Peoples R China;Fudan Univ, Zhongshan Hosp, Shanghai, Peoples R China.;Fudan Univ, Inst Brain Sci, Frontiers Ctr Brain Sci, State Key Lab Med Neurobiol, Shanghai, Peoples R China.;Fudan Univ, Inst Brain Sci, Frontiers Ctr Brain Sci, MOE, Shanghai, Peoples R China. (creator_code:org_t)
- 2019-11-19
- 2021
- English.
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In: Molecular Psychiatry. - : Springer Nature. - 1359-4184 .- 1476-5578. ; 26:8, s. 4367-4382
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- Alcohol misuse is a major public health problem originating from genetic and environmental risk factors. Alterations in the brain epigenome may orchestrate changes in gene expression that lead to alcohol misuse and dependence. Through epigenome-wide association analysis of DNA methylation from human brain tissues, we identified a differentially methylated region, DMR-DLGAP2, associated with alcohol dependence. Methylation within DMR-DLGAP2 was found to be genotype-dependent, allele-specific and associated with reward processing in brain. Methylation at the DMR-DLGAP2 regulated expression of DLGAP2 in vitro, and Dlgap2-deficient mice showed reduced alcohol consumption compared with wild-type controls. These results suggest that DLGAP2 may be an interface for genetic and epigenetic factors controlling alcohol use and dependence.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Meng, Weida
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Sjoholm, Louise ...
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Kononenko, Olga
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Tay, Nicole
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Zhang, Dandan
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Sarkisyan, Danii ...
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show more...
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Geske, Jennifer ...
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Ing, Alex
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Qiu, Wenqing
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Watanabe, Hiroyu ...
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Almamoun, Radwa
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Frieling, Helge
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Bleich, Stefan
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Cui, Donghong
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Biernacka, Joann ...
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Mayfield, R. Day ...
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Dang, Yongjun
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Karpyak, Victor ...
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Schumann, Gunter
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Bakalkin, Georgy
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Ekstrom, Tomas J ...
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Ruegg, Joelle
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Liu, Yun
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Molecular Psychi ...
- By the university
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Uppsala University
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Karolinska Institutet