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Träfflista för sökning "WFRF:(Mecocci P) ;conttype:(refereed);pers:(Proitsi P)"

Search: WFRF:(Mecocci P) > Peer-reviewed > Proitsi P

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  • Kurbatova, N., et al. (author)
  • Urinary metabolic phenotyping for Alzheimer's disease
  • 2020
  • In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10:1
  • Journal article (peer-reviewed)abstract
    • Finding early disease markers using non-invasive and widely available methods is essential to develop a successful therapy for Alzheimer's Disease. Few studies to date have examined urine, the most readily available biofluid. Here we report the largest study to date using comprehensive metabolic phenotyping platforms (NMR spectroscopy and UHPLC-MS) to probe the urinary metabolome in-depth in people with Alzheimer's Disease and Mild Cognitive Impairment. Feature reduction was performed using metabolomic Quantitative Trait Loci, resulting in the list of metabolites associated with the genetic variants. This approach helps accuracy in identification of disease states and provides a route to a plausible mechanistic link to pathological processes. Using these mQTLs we built a Random Forests model, which not only correctly discriminates between people with Alzheimer's Disease and age-matched controls, but also between individuals with Mild Cognitive Impairment who were later diagnosed with Alzheimer's Disease and those who were not. Further annotation of top-ranking metabolic features nominated by the trained model revealed the involvement of cholesterol-derived metabolites and small-molecules that were linked to Alzheimer's pathology in previous studies.
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  • Liu, YW, et al. (author)
  • APOE ε2 allele is associated with larger regional cortical thicknesses and volumes
  • 2010
  • In: Dementia and geriatric cognitive disorders. - : S. Karger AG. - 1421-9824 .- 1420-8008. ; 30:3, s. 229-237
  • Journal article (peer-reviewed)abstract
    • <i>Background:</i> The protective effect of the apolipoprotein E (APOE) &#917;2 allele against Alzheimer’s disease (AD) is controversial. <i>Objective:</i> Our purpose was to clarify if the &#917;2 allele affects regional cortical thicknesses and volumes. <i>Methods:</i> Regional cortical thicknesses and volumes were measured with an automated pipeline in 109 subjects with mild cognitive impairment, 114 AD patients and 105 age-matched healthy controls. <i>Results:</i> In the mild cognitive impairment group, the &#917;2 carriers had thicker regional cortices at the transverse temporal cortex and parahippocampal gyrus than the subjects with &#917;3/&#917;3, and a larger cerebral gray matter and smaller lateral ventricles than the &#917;3/&#917;3 and &#917;4 carriers. In the AD group, the &#917;2 carriers had significantly thicker entorhinal and transverse temporal cortices, a larger whole cerebral gray matter, and smaller lateral ventricles than the subjects with the &#917;3/&#917;3 genotype, and a significantly thicker entorhinal cortex and larger cerebral gray matter than &#917;4 carriers. No APOE2 effect was found in the control group. <i>Conclusion:</i> The APOE &#917;2 allele is associated with larger regional cortical thicknesses and volumes in mild cognitive impairment and AD.
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  • Result 1-10 of 15

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