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Oxygen Therapy in M...
Oxygen Therapy in Myocardial Infarction Patients With or Without Diabetes : A Predefined Subgroup Analysis From the DETO2X-AMI Trial.
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- Nyström, Thomas (author)
- Karolinska Institutet,Stockholm South General Hospital,Karolinska Inst, Sweden
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- James, Stefan, 1964- (author)
- Uppsala University,Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala Univ, Sweden
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- Lindahl, Bertil, 1957- (author)
- Uppsala University,Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala Univ, Sweden; Uppsala Univ, Sweden
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- Erlinge, David (author)
- Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Lund Univ, Sweden
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- Östlund, Ollie (author)
- Uppsala University,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Uppsala Univ, Sweden
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- Herlitz, Johan, 1949- (author)
- University of Borås,Högskolan i Borås,Akademin för vård, arbetsliv och välfärd,Department of Health Sciences, University of Borås, Borås, Sweden,Univ Boras, Dept Hlth Sci, Boras, Sweden
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- Omerovic, Elmir, 1968 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Univ Gothenburg, Sweden,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory
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- Mellbin, Linda (author)
- Karolinska Institutet,Karolinska University Hospital,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- Alfredsson, Joakim (author)
- Linköpings universitet,Linköping University,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Fröbert, Ole, 1964- (author)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology, Faculty of Medicine and Health, Örebro University,Orebro Univ, Fac Med & Hlth, Dept Cardiol, Orebro, Sweden
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- Jernberg, Tomas (author)
- Karolinska Institutet,Danderyd Hospital,Karolinska Inst, Sweden
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- Hofmann, Robin (author)
- Karolinska Institutet,Stockholm South General Hospital,Karolinska Inst, Sweden
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(creator_code:org_t)
- 2019-08-31
- 2019
- English.
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In: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 42:11, s. 2032-2041
- Related links:
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https://care.diabete...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- OBJECTIVE: To determine the effects of oxygen therapy in myocardial infarction (MI) patients with and without diabetes.RESEARCH DESIGN AND METHODS: In the Determination of the Role of Oxygen in Suspected Acute Myocardial Infarction (DETO2X-AMI) trial, 6,629 normoxemic patients with suspected MI were randomized to oxygen at 6 L/min for 6-12 h or ambient air. In this prespecified analysis involving 5,010 patients with confirmed MI, 934 had known diabetes. Oxidative stress may be of particular importance in diabetes, and the primary objective was to study the effect of supplemental oxygen on the composite of all-cause death and rehospitalization with MI or heart failure (HF) at 1 year in patients with and without diabetes.RESULTS: = 0.81). There was no statistically significant difference for the individual components of the composite end point or the rate of cardiovascular death up to 1 year. Likewise, corresponding end points in patients without diabetes were similar between the treatment groups.CONCLUSIONS: Despite markedly higher event rates in patients with MI and diabetes, oxygen therapy did not significantly affect 1-year all-cause death, cardiovascular death, or rehospitalization with MI or HF, irrespective of underlying diabetes, in line with the results of the entire study.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Människan i vården
- Människan i vården
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Nyström, Thomas
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James, Stefan, 1 ...
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Lindahl, Bertil, ...
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Erlinge, David
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Östlund, Ollie
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Herlitz, Johan, ...
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show more...
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Omerovic, Elmir, ...
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Mellbin, Linda
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Alfredsson, Joak ...
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Fröbert, Ole, 19 ...
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Jernberg, Tomas
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Hofmann, Robin
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetes Care
- By the university
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University of Borås
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Örebro University
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Uppsala University
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Lund University
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Linköping University
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Karolinska Institutet
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University of Gothenburg
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