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Enumeration	Reference	Cover	Find
1.	Patel, VL, et al. (author) Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness 2020 In: Cancer research. - 1538-7445. ; 80:3, s. 624-638 Journal article (peer-reviewed)
2.	Rebbeck, TR, et al. (author) Mutational spectrum in a worldwide study of 29,700 families with BRCA1 or BRCA2 mutations 2018 In: Human mutation. - : Hindawi Limited. - 1098-1004 .- 1059-7794. ; 39:5, s. 593-620 Journal article (peer-reviewed)
3.	Barnes, DR, et al. (author) Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants 2020 In: Genetics in medicine : official journal of the American College of Medical Genetics. - : Elsevier BV. - 1530-0366. ; 22:1110, s. 1653-1666 Journal article (peer-reviewed)
4.	Phelan, CM, et al. (author) Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer 2017 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 49:5, s. 680-691 Journal article (peer-reviewed)
5.	Bojesen, SE, et al. (author) Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer 2013 In: Nature genetics. - New york : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:4, s. 371-384 Journal article (peer-reviewed)
6.	Dunning, AM, et al. (author) Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170 2016 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 48:4, s. 374- Journal article (peer-reviewed)
7.	Kuchenbaecker, KB, et al. (author) Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers 2014 In: Breast cancer research : BCR. - : Springer Science and Business Media LLC. - 1465-542X .- 1465-5411. ; 16:6, s. 3416- Journal article (peer-reviewed)
8.	Mavaddat, N, et al. (author) Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk: an international prospective cohort of BRCA1 and BRCA2 mutation carriers 2020 In: Breast cancer research : BCR. - : Springer Science and Business Media LLC. - 1465-542X. ; 22:1, s. 8- Journal article (peer-reviewed)abstract BackgroundThe effect of risk-reducing salpingo-oophorectomy (RRSO) on breast cancer risk forBRCA1andBRCA2mutation carriers is uncertain. Retrospective analyses have suggested a protective effect but may be substantially biased. Prospective studies have had limited power, particularly forBRCA2mutation carriers. Further, previous studies have not considered the effect of RRSO in the context of natural menopause.MethodsA multi-centre prospective cohort of 2272BRCA1and 1605BRCA2mutation carriers was followed for a mean of 5.4 and 4.9 years, respectively; 426 women developed incident breast cancer. RRSO was modelled as a time-dependent covariate in Cox regression, and its effect assessed in premenopausal and postmenopausal women.ResultsThere was no association between RRSO and breast cancer forBRCA1(HR = 1.23; 95% CI 0.94–1.61) orBRCA2(HR = 0.88; 95% CI 0.62–1.24) mutation carriers. ForBRCA2mutation carriers, HRs were 0.68 (95% CI 0.40–1.15) and 1.07 (95% CI 0.69–1.64) for RRSO carried out before or after age 45 years, respectively. The HR forBRCA2mutation carriers decreased with increasing time since RRSO (HR = 0.51; 95% CI 0.26–0.99 for 5 years or longer after RRSO). Estimates for premenopausal women were similar.ConclusionWe found no evidence that RRSO reduces breast cancer risk forBRCA1mutation carriers. A potentially beneficial effect forBRCA2mutation carriers was observed, particularly after 5 years following RRSO. These results may inform counselling and management of carriers with respect to RRSO.

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Result 1-8 of 8

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Type of publication: journal article (8)

Type of content: peer-reviewed (8)

Author/Editor: Benitez, J. (8); Andrulis, IL (8); Simard, J (8); Easton, DF (8); Schmutzler, RK (8); Singer, CF (8); show more...; Goldgar, DE (8); Antoniou, AC (8); Olah, E (8); Frost, D. (8); Ejlertsen, B (7); Peterlongo, P (7); Hamann, U (7); Glendon, G (7); Radice, P (7); Manoukian, S (7); Jakubowska, A (7); Nevanlinna, H (7); Chenevix-Trench, G (7); Evans, DG (7); Buys, SS (7); McGuffog, L. (7); Thomassen, M. (7); Rantala, J. (7); Stoppa-Lyonnet, D. (7); Offit, K. (7); Montagna, M. (7); Engel, C. (7); Arnold, N. (7); Niederacher, D. (7); Davidson, R. (6); Cook, J. (6); Friedman, E. (6); Dennis, J (6); Foretova, L (6); Teo, SH (6); Couch, FJ (6); Toland, AE (6); Lubinski, J (6); Meindl, A (6); Wang-Gohrke, S (6); John, EM (6); Teixeira, MR (6); Peissel, B. (6); Laitman, Y. (6); Osorio, A. (6); Faivre, L. (6); Wappenschmidt, B. (6); Sutter, C. (6); Kast, K. (6); show less...

University: Karolinska Institutet (8); Lund University (6); Uppsala University (2); Umeå University (1)

Language: English (8)

Research subject (UKÄ/SCB): Medical and Health Sciences (6)

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