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Enhanced neurokinin...
Enhanced neurokinin 1 receptor availability in the amygdala in posttraumatic stress disorder
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- Michelgård Palmquist, Åsa, 1973- (author)
- Uppsala universitet,Psykiatri, Akademiska sjukhuset
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- Appel, Lieuwe (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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Fernandez, Manuel (author)
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- Furmark, Tomas (author)
- Uppsala universitet,Institutionen för psykologi
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- von Knorring, Lars (author)
- Uppsala universitet,Psykiatri, Akademiska sjukhuset
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Pissiota, Anna (author)
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Åhs, Fredrik (author)
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- Fredrikson, Mats (author)
- Uppsala universitet,Institutionen för psykologi
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(creator_code:org_t)
- English.
- Related links:
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https://urn.kb.se/re...
Abstract
Subject headings
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- Background: Posttraumatic stress disorder (PTSD) may result from experiencing severe distress, and is in part amygdala dependent. Animal studies demonstrate that stress and negative affect enhance the amygdala-release of the neuropeptide substance P (SP) which binds to the neurokinin 1 (NK1) receptor. This positron emission tomography (PET) study investigated if NK1 receptor availability in the amygdala of PTSD patients were different from healthy control subjects. Methods: Eleven male patients with DSM-IV defined PTSD and nine healthy male control subjects were PET scanned during 60 min at rest using the NK1 preferring tracer [11C]GR205171. Parametric Patlak images were generated and analyzed using statistical parametric mapping software. The effect of age was co-varied out because the amount of NK1 receptors decline with age. Results: PTSD patients had elevated uptake of [11C]GR205171 in the amygdala as compared to controls, also when anxiety differences were controlled for. Conclusions: We suggest that enhanced NK1 receptor availability could be a risk factor for developing PTSD rather than reflecting trauma induced alterations.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- PTSD; NK1 receptor; substance P; PET; amygdala; STAI-S
- Psychiatry
- Psykiatri
- Neuroscience
- Neurovetenskap
Publication and Content Type
- vet (subject category)
- ovr (subject category)
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