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Amoxicillin for acute lower-respiratory-tract infection in primary care when pneumonia is not suspected: a 12-country, randomised, placebo-controlled trial
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- Little, Paul (författare)
- University of Southampton, England
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- Stuart, Beth (författare)
- University of Southampton, England
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- Moore, Michael (författare)
- University of Southampton, England
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- Coenen, Samuel (författare)
- University of Antwerp, Belgium
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- Butler, Christopher C (författare)
- Cardiff University, Wales
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- Godycki-Cwirko, Maciek (författare)
- Medical University of Lodz, Poland
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- Mierzecki, Artur (författare)
- Pomeranian Medical University, Poland
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- Chlabicz, Slawomir (författare)
- Medical University of Bialystok, Poland
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- Torres, Antoni (författare)
- Hospital Clin Barcelona, Spain
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- Almirall, Jordi (författare)
- Hospital Mataro, Spain
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- Davies, Mel (författare)
- Ely, Wales
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- Schaberg, Tom (författare)
- Diakoniekrankenhaus, Germany
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- Mölstad, Sigvard (författare)
- Lund University,Lunds universitet,Linköpings universitet,Allmänmedicin,Hälsouniversitetet,CRC Malmö, Sweden,Samhällsmedicin,Forskargrupper vid Lunds universitet,Community Medicine,Lund University Research Groups
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- Blasi, Francesco (författare)
- University of Milan, Italy
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- De Sutter, An (författare)
- University of Ghent, Belgium
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- Kersnik, Janko (författare)
- University of Ljubljana, Slovenia
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- Hupkova, Helena (författare)
- Comenius University, Slovakia
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- Touboul, Pia (författare)
- Nice University Hospital, France
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- Hood, Kerenza (författare)
- Cardiff University, Wales
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- Mullee, Mark (författare)
- University of Southampton, England
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- OReilly, Gilly (författare)
- University of Southampton, England
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- Brugman, Curt (författare)
- University of Medical Centre Utrecht, Netherlands
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- Goossens, Herman (författare)
- University of Antwerp, Belgium
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- Verheij, Theo (författare)
- University of Medical Centre Utrecht, Netherlands
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(creator_code:org_t)
- Elsevier: Lancet, 2013
- Engelska.
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Ingår i: The Lancet - Infectious diseases. - : Elsevier: Lancet. - 1473-3099 .- 1474-4457. ; 13:2, s. 123-129
- Relaterad länk:
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http://www.ncbi.nlm.... (free)
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
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- Background Lower-respiratory-tract infection is one of the most common acute illnesses managed in primary care. Few placebo-controlled studies of antibiotics have been done, and overall effectiveness (particularly in subgroups such as older people) is debated. We aimed to compare the benefits and harms of amoxicillin for acute lower-respiratory-tract infection with those of placebo both overall and in patients aged 60 years or older. less thanbrgreater than less thanbrgreater thanMethods Patients older than 18 years with acute lower-respiratory-tract infections (cough of andlt;= 28 days duration) in whom pneumonia was not suspected were randomly assigned (1:1) to either amoxicillin (1 g three times daily for 7 days) or placebo by computer-generated random numbers. Our primary outcome was duration of symptoms rated "moderately bad" or worse. Secondary outcomes were symptom severity in days 2-4 and new or worsening symptoms. Investigators and patients were masked to treatment allocation. This trial is registered with EudraCT (2007-001586-15), UKCRN Portfolio (ID 4175), ISRCTN (52261229), and FWO (G.0274.08N). less thanbrgreater than less thanbrgreater thanFindings 1038 patients were assigned to the amoxicillin group and 1023 to the placebo group. Neither duration of symptoms rated "moderately bad" or worse (hazard ratio 1.06, 95% CI 0.96-1.18; p=0.229) nor mean symptom severity (1.69 with placebo vs 1.62 with amoxicillin; difference 0.07 [95% CI -0.15 to 0.007]; p=0.074) differed significantly between groups. New or worsening symptoms were significantly less common in the amoxicillin group than in the placebo group (162 [15.9%] of 1021 patients vs 194 [19.3%] of 1006; p=0-043; number needed to treat 30). Cases of nausea, rash, or diarrhoea were significantly more common in the amoxidllin group than in the placebo group (number needed to harm 21,95% CI 11-174; p=0.025), and one case of anaphylaxis was noted with amoxicillin. Two patients in the placebo group and one in the ammdcillin group needed to be admitted to hospital; no study-related deaths were noted. We noted no evidence of selective benefit in patients aged 60 years or older (n=595). less thanbrgreater than less thanbrgreater thanInterpretation When pneumonia is not suspected clinically, amoxicillin provides little benefit for acute lower-respiratory-tract infection in primary care both overall and in patients aged 60 years or more, and causes slight harms. less thanbrgreater than less thanbrgreater thanFunding European Commission Framework Programme 6, UK National Institute for Health Research, Barcelona Ciberde Enfermedades Respiratorias, and Research Foundation Flanders.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- TECHNOLOGY
- TEKNIKVETENSKAP
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- ref (ämneskategori)
- art (ämneskategori)