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RIFINs are adhesins implicated in severe Plasmodium falciparum malaria
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- Goel, Suchi (author)
- Karolinska Institutet
- Palmkvist, Mia (author)
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- Moll, Kirsten (author)
- Karolinska Institutet
- show more...
- Joannin, Nicolas (author)
- Westman, Mattias (author)
- Angeletti, Davide (author)
- Blixt, Ola (author)
- Ideström, Lars (author)
- Gahmberg, Carl G. (author)
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- (creator_code:org_t)
- 2015-03-09
- 2015
- English.
- In: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 21:4, s. 314-317
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Rosetting is a virulent Plasmodium falciparum phenomenon associated with severe malaria. Here we demonstrate that P. falciparum-encoded repetitive interspersed families of polypeptides (RIFINs) are expressed on the surface of infected red blood cells (iRBCs), bind to RBCs-preferentially of blood group A-to form large rosettes and mediate microvascular binding of iRBCs. We suggest that RIFINs have a fundamental role in the development of severe malaria and thereby contribute to the varying global distribution of ABO blood groups in the human population.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
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- ref (subject category)
- art (subject category)
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