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Träfflista för sökning "WFRF:(Monteiro ANA) ;mspu:(researchreview)"

Sökning: WFRF:(Monteiro ANA) > Forskningsöversikt

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1.
  • Klionsky, Daniel J., et al. (författare)
  • Guidelines for the use and interpretation of assays for monitoring autophagy
  • 2012
  • Ingår i: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
  • Forskningsöversikt (refereegranskat)abstract
    • In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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2.
  • Graca, Marisa, et al. (författare)
  • Designing urban green spaces for climate adaptation : A critical review of research outputs
  • 2022
  • Ingår i: Urban Climate. - : Elsevier. - 2212-0955. ; 42
  • Forskningsöversikt (refereegranskat)abstract
    • Urban green spaces provide important contributions to enhance climate adaptation, and therefore research in this area has increased exponentially in the last decades. While several studies showed that the morphology and type of living and built elements of urban green spaces greatly affect their performance, a persistent gap between theory and practice continues to pervade the design of green spaces. This study conducts a semi-systematic review of research published in the last decade to investigate to what extent recent research has produced evidence-based outputs relevant to practitioners concerning the design of outdoor urban green spaces in the context of climate adaptation. An innovative design-oriented approach is subsequently applied to critically review evidence-based research outputs considering a comprehensive spectrum of climate impacts and adaptation measures. Our specific objectives are to: i) identify evidence-based research outputs of relevance to practitioners according to type of climatic impact; ii) assess the level of relevance and geographical transferability of such outputs to support the design of urban green spaces; and iii) identify key challenges that might hinder the implementation of evidence-based guidelines. Our results support a call to align research to confront the wicked gap between scientific research and implementation in design practice.
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3.
  • Travaglini, Gabriele, et al. (författare)
  • The SAGEX review on scattering amplitudes
  • 2022
  • Ingår i: Journal of Physics A. - : IOP Publishing. - 1751-8113 .- 1751-8121. ; 55:44
  • Forskningsöversikt (refereegranskat)abstract
    • This is an introduction to, and invitation to read, a series of review articles on scattering amplitudes in gauge theory, gravity, and superstring theory. Our aim is to provide an overview of the field, from basic aspects to a selection of current (2022) research and developments.
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